Sentences with phrase «in airway disease»

You may hear your veterinarian use these terms and they are classical findings in airway disease.

Host - Microbe Interactions in Airway Disease: toward Disease Mechanisms and Novel Therapeutic Strategies — Emily K. Cope — mSystems

The findings, published in the online journal Scientific Reports, identify a novel mechanism that resveratrol, a compound found naturally in some plant foods such as grapes, uses to alleviate inflammation in airway disease.

The mice were either sensitized with house dust mite allergens or treated with a pro-inflammatory molecule called interleukin 13 (IL - 13), which induces mucous production in airway diseases.

Not exact matches

• Airway Therapeutics, a Cincinnati - based biotech firm focused on lung disease treatments, raised $ 11 million in Series B funding from new and existing investors.

Christi Hay, MD MPH Dr. Hay enjoys all aspects of pediatrics but she has special interests in developmental delays, early childhood literacy, breastfeeding, reactive airway disease / asthma, nutrition and fitness.

Nearly 30 million adults in the U.S. have obstructive sleep apnea, a chronic disease that involves the repeated collapse of the upper airway during sleep.

«Airway disease in racehorses more prevalent than previously thought.»

The result is that the small airways collapse during expiration, leading to an obstructive form of lung disease (airflow is impeded and air is generally «trapped» in the lungs in obstructive lung diseases).

«Asthma and airway allergic responses are among the most common chronic diseases in childhood affecting more than 6 million children in the US,» said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.

Their approach, in which micro-liters of liquid containing a drug are instilled into the lung, distributed as a thin film in the predetermined region of the lung airway, and absorbed locally, may provide much more effective treatment of lung disease.

According to the Centers for Disease Control and Prevention, more than 8 percent of children in the United States currently have asthma, a chronic disease that intermittently inflames and narrows the aDisease Control and Prevention, more than 8 percent of children in the United States currently have asthma, a chronic disease that intermittently inflames and narrows the adisease that intermittently inflames and narrows the airways.

A phenomenon linked to smoking known as expiratory central airway collapse — or ECAC — may have a stronger connection to underlying lung disease than previously believed, according to new research findings reported in the Journal of the American Medical Association.

COPD, an inflammatory disease of the airways and lungs, is the third leading cause of death in the U.S..

This decline in PAL was significantly associated with an increase in airflow obstruction (shown by a decline in FEV1) and an increase in total score on the St. George's Respiratory Questionnaire, which measures the impact of obstructive airway disease on overall health, daily life, and perceived well - being.

To further explore the therapeutic potential of these receptors, Kalbe says his team are planning to obtain tissue from people with chronic airway diseases to compare them to healthy tissue, to observe if the receptors change in abundance or function in disease states.

«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

According to the American Academy of Sleep Medicine, nearly 30 million adults in the U.S. have obstructive sleep apnea, a chronic disease that involves the repeated collapse of the upper airway during sleep.

Asthma is a chronic disease in which lung airways become swollen and narrow, making it difficult for air to move in and out of lungs.

Asthma is a disease of the human respiratory system in which the airways narrow, often in response to a «trigger» such as exposure to an allergen, cold air, exercise, or emotional stress.

More than 25 million people in the United States have asthma, a chronic lung disease that inflames and narrows the airways causing recurring periods of wheezing, chest tightness, shortness of breath and coughing.

In addition, because the investigators have data indicating that other important airway pathogens that cause acute bacterial pneumonia also may use M - cells to cause severe disease, they are extending their work beyond tuberculosis.

«Understanding these mechanisms in vivo would allow for targeted blockade of bacterial transport via vaccinations or medications, which could ultimately lead to new ways to prevent or treat airway infectious diseases,» Dr. Shiloh explained.

Researchers observed that the immune cells, called CD4 T - cells, in the airways of severe asthmatics secreted different inflammatory proteins than those in mild disease, particularly interferon gamma.

Toxins from mold found growing on nuts or corn can weaken the airways» self - clearing mechanisms and immunity, opening the door for respiratory diseases and exacerbating existing ones, suggests a study in Nature Scientific Reports published this month from otolaryngology researchers at the Perelman School of Medicine at the University of Pennsylvania.

CT scans found emphysema or airway thickening in 42 percent of the disease - free participants.

Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).

The conducting airways are involved in major diseases such as asthma and chronic obstructive lung diseases.

«When the disease is still in the small airways, it tends to not show symptoms.

Read the full paper titled Intranasal administration of mesenchymoangioblast - derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease published in the FASEB Journal.

Our finding of sinusitis, bronchial hyperreactivity, and bronchial responsiveness in firefighters with World Trade Center cough is important but not surprising.17 - 20 An unexpected finding was that 87 percent of such firefighters reported symptoms of gastroesophageal reflux disease; such symptoms are generally reported by less than 25 percent of patients with chronic cough.1, 21,22 Despite the strong associations between gastroesophageal reflux disease and chronic cough17 - 20 and between gastroesophageal reflux disease and asthma,23 - 25 it remains unclear whether gastroesophageal reflux disease causes either condition.26 The causative mechanism may be repeated aspiration of minute amounts of refluxed material; vagally mediated esophageal, tracheobronchial, or laryngobronchial cough reflexes; or neurally mediated bronchial inflammation.23, 24,26 Involvement of the posterior nasopharynx is common in patients with gastroesophageal reflux disease, 27 whereas bronchial hyperreactivity may not be present.25, 26 For these reasons, we classified gastroesophageal reflux disease as an upper - airway symptom (Figure 2).

Professor Bruno D'Agostino from the University of Naples said: «For many years, my research group has been working on the role of nociceptin in the regulation of airway responsiveness in animal models, and it is very interesting translating our results into clinic area regarding asthma, a disease that is forecast to grow over the next years.»

«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»

The Division of Pulmonary Medicine deals with the breath of life in all its aspects: control of breathing; sleep disorders; obstruction to airflow in the common diseases of upper and lower airways such as croup, bronchiolitis, asthma, cystic fibrosis, and bronchopulmonary dysplasia; restriction to lung function from disorders affecting the chest wall, the musculature, the nervous system, or lung tissue itself; congenital anomalies; accidents such as inhalation of foreign bodies, hydrocarbons, or toxic gases; secondary effects of non-pulmonary system disorders such as gastrointestinal reflux, myopathy, or cardiac dysfunction; disease of the upper respiratory tract including rhinitis and sinusitis; and so on.

Researchers have proved that a single «master switch» enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD).

The collaborative work by Merck and Emulate researchers enabled new functionality for the Small Airway Lung - Chip to demonstrate the mechanism of action for therapeutic compounds acting on inflammatory disease states in the small airway, particularly in diseases such as aAirway Lung - Chip to demonstrate the mechanism of action for therapeutic compounds acting on inflammatory disease states in the small airway, particularly in diseases such as aairway, particularly in diseases such as asthma.

«This collaboration has already resulted in exciting new capabilities and insights for R&D for small airway diseases, and we look forward to further advancing the application of the Organ - Chips to improve therapeutic development».

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

The bill, expected to come up for a vote in the Senate after Thanksgiving, also would require the U.S. Centers for Disease Control and Prevention to conduct a five - year study on the human health effects of per - and polyfluoroalkyl substances — classes that include the compounds in Airway Heights» groundwater.

12/3/2008 Treating Sleep Apnea in Alzheimer's Patients Helps Cognition Continuous positive airway pressure (CPAP) treatment seems to improve cognitive functioning in patients with Alzheimer's disease who also suffer from obstructive sleep apnea, according to the results of a randomized clinical trial conducted at the Un... More...

Secretory IgA from submucosal glands does not compensate for its airway surface deficiency in chronic obstructive pulmonary disease.

It's no secret that smoking is harmful, but it's been hard to study its effects on chronic obstructive pulmonary disease (COPD), a disease that leaves sufferers short of breath thanks to inflammation of the small airways in the lung.

The biological mechanisms by which toxins in tobacco smoke cause lung cancer are complex and still not completely understood, but carcinogens in tobacco smoke may not only act as genetic inducers but also act to promote progression of the disease.6 7 As well as potentially reducing the risk of cancer related morbidity and mortality, quitting smoking at diagnosis could reduce overall mortality, as smoking cessation reduces mortality from other diseases such as heart disease, stroke, and chronic obstructive airways disease.8 9

Determining the mechanism for these sex - based differences in airway inflammation and the contribution of the microbiome in animal models would improve our ability to treat or prevent asthma and other autoimmune diseases in women.

Objectives: This study investigated comorbidity in chemical intolerance (CI) and building - related intolerance (BRI) with (i) chronic sinusitis, chronic obstructive pulmonary disease, allergic and nonallergic asthma and allergic rhinitis, and (ii) airway inflammatory symptoms.

Dr. Welsh's research is focused on the pathophysiology of airway disease in cystic fibrosis and on the DEG / ENaC family of Na + channels.

Methylation prevents excessive gene activity in X-linked genes, however much remains unknown about how this process influences infants» risk of developing airway diseases.

Dr. Holtzman conducts research on the role of infection in the development and progression of chronic airway diseases such as asthma and COPD.

PHILADELPHIA — Toxins from mold found growing on nuts or corn can weaken the airways» self - clearing mechanisms and immunity, opening the door for respiratory diseases and exacerbating existing ones, suggests a study in Nature Scientific Reports published this month from otolaryngology researchers at the Perelman School of Medicine at the University of Pennsylvania.