Peripheral blood stem cells are generally used in autologous transplantations, while either marrow or peripheral blood stem cells are used
in allogeneic transplantations.
Not exact matches
In the study, analysis of patient samples demonstrated that high LSC17 scores meant poor outcomes with current standard treatment, even for patients who had undergone
allogeneic stem cell
transplantation.
In contrast, injections of the cells into immunologically unmatched recipients (called an
allogeneic transplantation) caused the body to mount a stronger immune response.
Collaboration with Hematology and Bone Marrow
Transplantation Unit research group
in molecular diagnostics applied to the management of patients undergoing
allogeneic SCT, especially for the detection of minimal residual disease and early relapse.
In that program, we focused on treating children with both malignant and genetic conditions with generally
allogeneic hematopoietic stem cell
transplantation.
The only documented long - term complete remissions reported
in multiple myeloma patients have occurred with
allogeneic bone marrow
transplantation, where a donor's blood stem cells (graft) are transplanted into the patient (host) with multiple myeloma.
These reports suggest that
transplantation of MSC could be beneficial
in patients with various disorders requiring tissue regeneration, and provide evidence supporting the tolerance of
allogeneic MSC by recipients.
Allogeneic Sibling Donor Peripheral Blood Stem Cells
Transplantation With Myeloablative Conditioning for Chronic Myeloid Leukemia
in Blast Crisis - Successful Treatment Despite Severe Phase of the Disease
Suppression of
allogeneic T - cell proliferation by human marrow stromal cells: implications
in transplantation.
Bornhäuser M, Kienast J, Trenschel R, et al Reduced - intensity conditioning versus standard conditioning before
allogeneic haemopoietic cell
transplantation in patients with acute myeloid leukaemia
in first complete remission: a prospective, open - label randomised phase 3 trial.
Board - certified
in internal medicine and medical oncology, Dr. Collins has 25 years of experience
in bone marrow
transplantation and has participated
in some 2,500 autologous and
allogeneic transplants.
Horwitz et al 79 reported that donor MSC contributed to bone remodelling after
allogeneic stem cell
transplantation (SCT)
in 3 children with osteogenesis imperfecta, a rare genetic disorder of type I collagen.
One promising solution to increase long - term overall survival has been
in the area of
allogeneic hematopoietic stem cell
transplantation (HCST).
In the future, outpatient blood and bone marrow stem cell
transplantation will be offered to a broader group of patients with other blood disorders and for
allogeneic transplants (transplant from non-twin donor stem cells).
Editorial: Empiric antibiotic use
in allogeneic hematopoietic cell
transplantation: should we avoid anaerobe coverage?
Hutter G and Thiel E
Allogeneic transplantation of CCR5 - deficient progenitor cells
in a patient with HIV infection: an update after 3 years and the search for patient no. 2.
Use of a lower dose of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose
in children with hematologic malignancies undergoing
allogeneic hematopoietic stem cell
transplantation (HSCT) from an unrelated donor, according to the results of a study published
in Lancet Oncology.
Allogeneic stem cell
transplantation to leukaemic patients,
in which the patient's own diseased bone marrow is replaced by healthy donor material, is one of the best - established and most effective immunological therapies.
Warren D. Shlomchik, M.D. Yale University Memory T cells for improved immune reconstitution and GVL
in allogeneic hematopoietic stem cell
transplantation
We found that,
in the
allogeneic group, IFN - γ +, IL - 17A +, and IFN - γ / IL -17 A double - positive CD4 + T cells derived from spleen (Fig. 2A, 2B) and MLN (Supplemental Fig. 1A, 1B) increased since the early stage after
transplantation compared with the syngeneic group, whereas the IFN - γ — and / or IL - 17A — producing CD8 + T cells increased only at the late stage (Supplemental Fig. 1C, 1D).
Low - Dose ATLG Prevents GVHD
in Pediatric Hematologic Malignancies: A newly published randomized phase III study of pediatric patients showed lower doses of rabbit anti — T - lymphocyte globulin (ATLG) was superior to a higher dose
in children with hematologic malignancies undergoing
allogeneic hematopoietic stem cell
transplantation from an unrelated donor.
Ponatinib Extends Survival Over Transplant
in Chronic Phase CML: The results of a new study that included patients from the PACE trial and the European Bone Marrow Transplant registry revealed that treatment with ponatinib yielded better overall survival (OS) compared with
allogeneic stem cell
transplantation (allo - SCT)
in patients with chronic phase chronic myeloid leukemia (CP - CML) with a T315I mutation.
Allogeneic cells, particularly mismatched or haploidentical cells,
in the context of hematopoietic
transplantation have been found to provide potent immune surveillance for both hematologic and solid tumor malignancies
in a process referred to as graft - versus - tumor [13]--[15].
Anti-CD13 Abs
in children with extensive chronic GVHD and their relation to soluble CD13 after
allogeneic blood and marrow
transplantation from a Children's Oncology Groups Study, ASCT0031.
These
allogeneic cells have the potential to participate
in immune surveillance for breast or other cancers as observed
in clinical hematopoietic stem cell
transplantation.
By integrating the aforementioned observations of FMc
in autoimmunity and
transplantation immunobiology, we reasoned that
allogeneic FMc might provide immune surveillance for breast cancer
in parous women.
Acute myeloid leukemia (AML) is the leading cause of leukemia mortality
in the United States.1 Curative treatment involves intensive induction chemotherapy, before proceeding to either consolidation chemotherapy or
allogeneic stem cell
transplantation based on the patient's risk for relapse.2 This approach has been employed for > 4 decades and, although most individuals achieve complete remissions with front - line therapy, 3 the majority of patients ultimately relapse with drug - resistant disease, and overall survival rates remain disappointingly poor.4 The limited ability of many patients to tolerate the intense chemotherapy - based treatments,
in particular hematological toxicity, further contributes to the poor outcomes noted
in this disease.
Macmillan, 2014; Holler, E., et al. «Metagenomic analysis of the stool microbiome
in patients receiving
allogeneic stem cell
transplantation: Loss of diversity is associated with use of systemic antibiotics and more pronounced
in gastrointestinal graft - versus - host disease.»