Sentences with phrase «in aneuploid cells»
Having an irregular number of chromosomes, almost by definition, leads to imbalances in the numbers of proteins expressed in aneuploid cells.
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In short, the suddenly awakened cells displayed massive genomic instability, quite beyond their simple aneuploid condition at the start of the experiments.
«We think this rapid evolution could allow the aneuploid cells to acquire some of the pro-cancer characteristics that might promote cancer development or cause a cancer in a person to proliferate,» Sheltzer says.
Cells isolated from lungs of infected animals exhibited relatively stable aneuploid phenotypes and were found to retain their aneuploid chromosome in 70 — 80 % of isolates based on multiplex PCR [20 isolates were analyzed from each strain, 15 were aneuploid for MN35 (75 %), 16 for MN55 (80 %), 14 for MN77 (70 %), and 15 for MN89 (75 %)(Figure S9)-RSB-.
We have also identified a transcriptional signature of aneuploidy that is associated with cellular stress and slow proliferation, and is found in aneuploid primary and cancer cells across a host of organisms.
We're working to understand how aneuploidy impacts cancer progression, in hopes of developing therapies that can specifically eliminate aneuploid cancers while leaving normal cells unharmed.
Thus, differences between aneuploid and euploid cells may represent crucial therapeutic vulnerabilities in cancer.
Cole Laboratory publishes new paper in Cell (10/19/2017)- Chromosome mis - segregation creates cells with the wrong number of chromosomes (aneuploid cells).