Sentences with phrase «in apolipoprotein»

Specifically, the researchers looked at mutations in the apolipoprotein A5 gene, a known determinant of triglyceride concentrations.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

Two renal - risk variants in the apolipoprotein L1 gene (APOL1), termed G1 and G2, are present in a large percentage of African American organ donors and kidney transplant recipients.

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E — Deficient Mice.

Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.

Not exact matches

Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL - cholesterol, and apolipoprotein - B in young men and women

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

Apolipoprotein E is a protein that is important in the repair and recovery of brain cells that have been damaged due to concussion.

HDL with a small proinflammatory protein called apolipoprotein C - III (apoC - III) on its surface may nearly double the risk of heart disease in healthy men and women, according to Frank Sacks, professor of cardiovascular disease prevention at the Harvard School of Public Health and senior author on a paper in the April Journal of the American Heart Association.

We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in «reverse cholesterol transport.»

In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E.

A large - scale genetic analysis in PSP patients, however, identified a common tau sequence that increases by 5.5 times a person's chances of developing the disease, making this variant a stronger risk factor for PSP than one copy of the apolipoprotein E-ε4 variant is for Alzheimer's.

The gene in question, apolipoprotein E (apoE), codes for a protein in the brain's astrocyte cells that seems to help spur nerve cell growth and clear up debris from neuronal injuries brought by head trauma, stroke, or cerebral hemorrhage.

In «Greater Cognitive Deficits with Sleep - Disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis,» researchers report that study participants carrying the apolipoprotein?

Apolipoprotein E comes in three versions, or variants, called ApoE2, ApoE3 and ApoE4.

In 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the braiIn 1993, Poirier and his Montreal - based team co-discovered an important genetic risk factor involved in the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the braiin the most common form of the disease: a defective gene, called Apolipoprotein E type 4 (ApoE4), that prevents the normal transport of cholesterol and phospholipids to the brain.

Together, they looked at two well - known genetic risk factors for CKD in black people, the mutated G1 or G2 variations in the gene known as apolipoprotein L1 (APOL1).

Two studies published in the Journal of Alzheimer's Disease indicate that some of the pathologic changes associated with Alzheimer's disease in older individuals are not apparent in young people who carry the apolipoprotein (APOE) genetic risk factor for developing the disease.

Humans carry a gene for a protein in cells called apolipoprotein E, which helps clear amyloid - beta from the brain by binding to it and breaking it down.

Transplanted hearts lasted in four groups of mice as follows: • 21 days: mice with hyperlipidemia caused by a genetic mutation of apolipoprotein E (ApoE) placed on a high - fat diet • 51 days: healthy mice placed on a high - fat diet leading to hyperlipidemia • 61 days: mice with hyperlipidemia caused by a genetic mutation of ApoE on a lower - fat diet • More than 100 days: healthy mice placed on a lower - fat diet

With the same diet pattern, levels of LDL cholesterol and apolipoprotein B (a secondary end point) increased, with no changes in HDL cholesterol or triglyceride level or blood pressure.»

Walker said that the effect of one standard deviation increase in the overall inflammation score in mid-life on brain volume decades later was similar to the effect associated with having one copy of the apolipoprotein E (APOE) e4 gene that increases the risk of Alzheimer's disease.

Expression of apolipoprotein E mRNA in the epithelium and interstitium of the testis and the epididymis.

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction.

The goal of this project is to elucidate the functional role of apolipoprotein E (APOE) in microglia, the resident immune cells of the brain.

Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.

Apolipoprotein (a), through Its Strong Lysine - binding Site in KIV10, Mediates Increased Endothelial Cell Contraction and Permeability via a Rho / Rho Kinase / MYPT1 - dependent Pathway.

Using a small fragment of apolipoprotein B as a guide, Brian Spencer, a postdoctoral fellow in the Verma lab and the study's lead author, successfully shepherded the enzyme glucocerebrosidase into the brains of adult mice.

Depressed neurofilament expression associates with apolipoprotein E3 / E4 genotype in maturing human fetal neurons exposed to HIV - 1.

Human genetic studies strongly point to apolipoprotein E (APOE) and microglia (the immune cells of the brain) as, respectively, the most important gene and cell type in the chain of events leading to Alzheimer's disease (AD), a common disorder in the elderly in which the brain is damaged and memories falter.

DONG ET AL.The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer's disease (AD), but the role of the ApoE4 protein in AD has long been elusive.

Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid - beta (Aβ) peptides and apolipoprotein E4 (apoE4) impair the growth of new neurons born in adult brains.

Understanding the Role of Apolipoprotein E in Microglia Edoardo Marcora, PhD Icahn School of Medicine at Mount Sinai (New York, NY)

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E... (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.

CLU is a confirmed AD gene from genome - wide association study, and encodes apolipoprotein J, which has been shown to chaperone re-entry of Aβ into the brain following export of the peptide from the brain into the blood.49 Interestingly, genes encoding two peptidases known to degrade Aβ were also decreased in expression in blood pre — post intervention as part of the vacation effect: MME (P = 0.00019) and ECE1 (P = 0.0037).

The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5 - HT2A and serotonin transporter linked polymorphic region -5-HTTLPR - of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E

These NIH - funded studies investigate the role of Apolipoprotein F (ApoF) in regulating cholesterol transport.

Freedman, B. I., et al. «Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.»

were used to examine the potential association between VRF scores and the change in MMSE and CDR - SB scores, adjusting for age, sex, and the apolipoprotein ɛ 4 allele (APOE4).

In 1999, he was named an Alexander Hollaender Distinguished Fellow where he identified a novel apolipoprotein (ApoA5) involved in human and mouse triglyceride metabolisIn 1999, he was named an Alexander Hollaender Distinguished Fellow where he identified a novel apolipoprotein (ApoA5) involved in human and mouse triglyceride metabolisin human and mouse triglyceride metabolism.

In a genome - wide analysis of up to 17 503 participants in PROMIS, we identified genetic variants associated with either apolipoprotein (a) isoform size or lipoprotein (a) concentratioIn a genome - wide analysis of up to 17 503 participants in PROMIS, we identified genetic variants associated with either apolipoprotein (a) isoform size or lipoprotein (a) concentratioin PROMIS, we identified genetic variants associated with either apolipoprotein (a) isoform size or lipoprotein (a) concentration.

Involved in the initial discovery of apoE as a major apolipoprotein regulating lipoprotein metabolism, including that apoE is induced by fat / cholesterol feeding in atherogenesis.

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

Methods: In this mendelian randomisation study, we measured lipoprotein (a) concentration and determined apolipoprotein (a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene) and a serum - based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMISIn this mendelian randomisation study, we measured lipoprotein (a) concentration and determined apolipoprotein (a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene) and a serum - based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMISin the LPA gene) and a serum - based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMISin patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMIS).

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

Lipoprotein (a)- lowering interventions could be preferentially effective in reducing the risk of coronary heart disease in individuals with smaller apolipoprotein (a) isoforms.

Our laboratory focuses on the structure and function of apolipoprotein (apo) E, including its critical role in cholesterol homeostasis, atherosclerosis and neurodegenerative disorders such as Alzheimer's disease and traumatic brain injury.

The abnormal composition of apolipoproteins (apo) in the lipoprotein fractions from the patient (P) is compared with the compositions of his mother (M) and a normolipidemic control participant (C).