He has developed paradigms that are being used to screen drugs that enhance social function, and is developing novel strategies for drug discovery for treating social impairments
in autism and schizophrenia.
For too long, psychology has mistakenly relied on the same language to describe similar features
in autism and schizophrenia.
A2 Corp claimed the beta casein A1 found in most cows» milk sold in New Zealand had been linked with the development of coronary heart disease, childhood diabetes and also implicated
in autism and schizophrenia.
Not exact matches
Autism and Down's syndrome
and schizophrenia and Alzheimer's are swallowed up
in victory.
According to Dr. Keith Wolford, author of the Devil
in the Milk, there is a correlation
in the consumption of A1 cow proteins
and the incidence of type 1 diabetes, autoimmune disease, heart disease,
autism,
and schizophrenia.
But what of suggestions that A2 milk provides levels of protection from
autism in children, as well as
schizophrenia, diabetes
and heart disease?
Back then, it was hypothesised that the A1 beta - casein protein found
in the milk of some cows was a risk factor for diabetes, heart disease
and possibly also
schizophrenia and autism.
In addition to the new work's potential for RS, there is speculation that it could pave the way to treatments for other neurological disorders, such as learning disabilities,
schizophrenia,
autism and newborn encephalopathy as well as some mental retardation that has also been linked to the Mecp2 gene.
«The interaction between the two types of neurons could also help explain the presence of seizures
in patients with
schizophrenia, dementia
and some forms of
autism.»
Altered patterns of variability were observed
in the brain's default network with
schizophrenia,
autism and Attention Deficit Hyperactivity Disorder (ADHD) patients.
Osaka University researchers show
in a multi-institute collaboration that a single amino acid substitution
in the protein CX3CR1 may act as predictor for
schizophrenia and autism
This discovery also explains why sensory interferences, including synesthesias
and hallucinations, can occur
in people suffering from neurodevelopmental disorders such as
autism or
schizophrenia.
In the heady postwar years, hundreds of promising studies were conducted in the United States, Canada, and Europe on the use of LSD and other psychedelics, like peyote, to treat such psychiatric maladies as schizophrenia, autism, drug addiction, alcoholism, and chronic depressio
In the heady postwar years, hundreds of promising studies were conducted
in the United States, Canada, and Europe on the use of LSD and other psychedelics, like peyote, to treat such psychiatric maladies as schizophrenia, autism, drug addiction, alcoholism, and chronic depressio
in the United States, Canada,
and Europe on the use of LSD
and other psychedelics, like peyote, to treat such psychiatric maladies as
schizophrenia,
autism, drug addiction, alcoholism,
and chronic depression.
«Aberrant synapse formation is important
in the pathogenesis of
schizophrenia and autism,» says Osaka University Professor Toshihide Yamashita, one of the authors of the study.
Studies have identified an association between maternal infection
and inflammation
and preterm birth,
in addition to the development of cerebral palsy
and neuropsychiatric conditions such as
schizophrenia and autism.
The scientists believe that immune proteins
in the brain may be so significant that disruption during development might also contribute to such conditions as
autism and schizophrenia.
Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene
in over 7000
schizophrenia and autism patients
and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.
These newer studies are beginning to uncover the reasons why men are much more susceptible to neurodegenerative diseases like Parkinson's
and ALS; why
autism, dyslexia, stuttering
and early onset
schizophrenia are three to four times more prevalent
in boys;
and why attention deficit hyperactivity disorder is diagnosed 10 times more often
in boys.
And that in turn may have implications for how we work though brain - health issues where short - term memory is a problem, including Alzheimer disease, schizophrenia, autism, depression and attention deficit disorder.&raq
And that
in turn may have implications for how we work though brain - health issues where short - term memory is a problem, including Alzheimer disease,
schizophrenia,
autism, depression
and attention deficit disorder.&raq
and attention deficit disorder.»
Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI,
and like humans with
autism or
schizophrenia — undergo inadequate synaptic pruning
in some parts of their brains.
At Caltech, developmental neurobiologist Paul Patterson found he could induce the core symptoms of
autism and schizophrenia in mice by giving their mothers the flu during pregnancy, or by arousing their immune systems
in utero with an injection of foreign RNA.
The largest of its kind, the study examined genetic data
in 100,000 individuals including 40,000 people with a diagnosis of
schizophrenia and also found that some of the genes identified as increasing risk for
schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability
and autism spectrum disorders.
Neuroscientists think that conditions such as
schizophrenia and autism stem from problems
in neural connectivity.
Many conditions, including
schizophrenia and bipolar disorder, as well as developmental conditions like
autism, are at least
in part inherited from our parents.
Schmid says enhancing habituation
and sensory filtering
in autism spectrum disorder
and schizophrenia might have beneficial effects not only on hyper -
and hyposensitivity, but also on cognitive function.
Risperidone is used to treat various psychiatric disorders
in adults
and children, including
autism, bipolar disorder,
and schizophrenia,
and prescribing rates for children have increased nearly eight-fold over the last two decades.
This helps us
in everyday life, but it also holds great potential when trying to understand why people with
autism and schizophrenia have difficulties with social interaction.
The conditions included very rare disorders inherited
in families,
and more common diseases such as
autism,
schizophrenia and obesity.
In the real brain, maintaining a proper balance in neural network activity is important; disruptions in it appear to foster disorders such as epilepsy, and perhaps schizophrenia and autis
In the real brain, maintaining a proper balance
in neural network activity is important; disruptions in it appear to foster disorders such as epilepsy, and perhaps schizophrenia and autis
in neural network activity is important; disruptions
in it appear to foster disorders such as epilepsy, and perhaps schizophrenia and autis
in it appear to foster disorders such as epilepsy,
and perhaps
schizophrenia and autism.
The same conflict that gives rise to
autism and schizophrenia may be at work
in all of us, nudging us one way or another on the spectrum from father - brain to mother - brain.
Upper layer neurons are also frequently affected
in psychiatric disorders such as
schizophrenia and autism.
Several neurological disorders, including
autism and schizophrenia, are thought to be driven
in part by the failure of myelin to properly surround axons during development.
They contend that upsets
in the tug - of - war between imprinted genes
in the brain could help explain the origins of some mental illnesses, including
autism and schizophrenia.
In their new paper, Cheyette and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorder
In their new paper, Cheyette
and his team examined the gene DIXDC1 — a key piece of the WNT signaling pathway that is active
in tissues of the brain and interacts with DISC1, a gene implicated in schizophrenia, depression, bipolar disorder, and autism spectrum disorder
in tissues of the brain
and interacts with DISC1, a gene implicated
in schizophrenia, depression, bipolar disorder, and autism spectrum disorder
in schizophrenia, depression, bipolar disorder,
and autism spectrum disorders.
Statistically significant hazard ratios for specific groups of psychiatric disorders were found for
schizophrenia and psychoses (1.27, 1.16 - 1.38), affective disorders (1.32, 1.25 - 1.39), anxiety
and other neurotic disorders (1.37, 1.32 - 1.42), mental
and behavioural syndromes including eating disorders (1.13, 1.04 - 1.24), mental retardation (1.28, 1.17 - 1.40), mental development disorders including
autism spectrum disorders (1.22, 1.16 - 1.28),
and behavioural
and emotional disorders including attention deficit hyperactivity disorder (ADHD)(1.40, 1.34 - 1.46), when compared with rates
in naturally conceived children.
The same change is seen
in patients with neuropsychiatric conditions such as
schizophrenia, Down's syndrome,
and autism,
and in people with poor impulse control.
Mutations seen
in people with
autism,
schizophrenia,
and bipolar disorder cause loss of synapses
in mice
First, an analysis of genomic data from 6,000 patients with
autism spectrum disorders, 1,000 patients with bipolar disorder,
and 2,500 patients with
schizophrenia by co-first author Pierre - Marie Martin, PhD, a postdoctoral researcher
in Cheyette's lab, revealed that disruptive mutations
in the main neuronal form of DIXDC1 were present about 80 percent more often
in psychiatric patients (0.9 percent had mutations) compared to healthy controls (0.5 percent had mutations).
Even though a biomarker shared by
schizophrenia and autism might not reveal anything specific to
autism, he adds, it might highlight a neural process that is central to social cognition,
and that might be altered
in several conditions, including
autism.
The new findings, published 21 January
in Schizophrenia Research, support an alternate theory:
Autism and schizophrenia are independent outcomes of the same genetic syndrome.
That study, too, found no relationship between
autism features
in childhood
and schizophrenia in adulthood.
But bringing
autism and schizophrenia back together — at least
in a research setting — could generate new leads for characterizing
and addressing both.
Looking at these results, along with Pinkham
and Sasson's findings, Eack says, «There may be certain things that are particularly prominent to focus on
in schizophrenia —
and other things that may be less prominent or more prominent to focus on
in autism.
Sasson was studying developmental psychology, with a focus on
autism,
and Pinkham was interested
in schizophrenia and clinical psychology.
Two years later, the team received funding for a larger - scale investigation, evaluating a whole suite of social skills
in 54 individuals with
schizophrenia, 54 with
autism and average intelligence quotients (IQ)
and 56 typical adults.
Many of the eight genes are active during brain development
and may play a role
in neuropsychiatric disorders such as
autism and schizophrenia, Sanders says.
This idea of finding shared neural processes presupposes that the same problems explain the social difficulties seen
in people with
autism and those with
schizophrenia — an idea that Sasson
and Pinkham's work has brought into question.
«What there generally hasn't been
in the literature are very many studies comparing
autism and schizophrenia directly,» Foss - Feig says.
The two diagnoses started to take on separate lives, with age of diagnosis — around 4 years
in autism and between 16
and 30
in schizophrenia — becoming an important differentiator.
Then she learned that people with 22q duplication — abnormal repetition, or duplication, of genetic material
in chromosome 22 — had learning delays
and sometimes
autism, but a lower risk for
schizophrenia than that found
in the general population.