In the 1990s, scientists found the first of those signaling systems, a family of ephrin proteins that are present in graded fashion in the brain and are involved
in axon guidance.
«A better understanding of the mechanisms involved
in axon guidance will offer new possibilities for developing techniques to treat lesions resulting from spinal cord injuries, and possibly even neurodegenerative diseases.»
His laboratory implicated endocannabinoids
in axon guidance and identified the molecular substrates of Δ9 - tetrahydrocannabinol action in developing neurons.
Not exact matches
The genes we detect are involved
in the regulation of cell development, and are specifically important
in synapse formation,
axon guidance and neuronal differentiation.
In collaboration with the Program in Neuroengineering at McGill University, Dr. Charron's team developed an innovative technique to recreate the concentration gradients of guidance cues in vitro, that is to say they can study the developing axons outside their biological contex
In collaboration with the Program
in Neuroengineering at McGill University, Dr. Charron's team developed an innovative technique to recreate the concentration gradients of guidance cues in vitro, that is to say they can study the developing axons outside their biological contex
in Neuroengineering at McGill University, Dr. Charron's team developed an innovative technique to recreate the concentration gradients of
guidance cues
in vitro, that is to say they can study the developing axons outside their biological contex
in vitro, that is to say they can study the developing
axons outside their biological context.
In those instances, we revealed that a combination of guidance cues can behave in synergy with one another to help the axon interpret the gradient's direction.&raqu
In those instances, we revealed that a combination of
guidance cues can behave
in synergy with one another to help the axon interpret the gradient's direction.&raqu
in synergy with one another to help the
axon interpret the gradient's direction.»
«We found that the steepness of the gradient is a critical factor for
axon guidance; the steeper the gradient, the better the
axons respond to
guidance cues,» says Tyler F.W. Sloan, PhD student
in Dr. Charron's laboratory and first author of the study.
«
In addition, we showed that the gradient of one
guidance cue may not be steep enough to orient
axons.
In this paper, IRCM scientists uncovered how
axons use information from multiple
guidance cues to make their pathfinding decisions.
With his vast knowledge, he recommended several topics and I soon became very interested
in cell motility and
axon guidance.
My lab is investigating the normal cellular functions of signaling pathways implicated
in neurological disease, with an emphasis on
axon growth and
guidance.
To investigate this, we are characterizing the role of the SMN protein
in axon growth and
guidance in vivo, as well as identifying proteins and mRNA targets that interact with SMN
in neurons.
Our studies reveal previously - unknown roles for glia
in pioneer -
axon guidance, and suggest conserved principles of brain formation.
Figure summarizing the three major steps of
axon development
in the CNS:
axon specification during neuronal polarization,
axon growth and
guidance,
axon branching and presynaptic development (Modified from Lewis, Courchet and Polleux, The Journal of Cell Biology, 2013).
The
axon guidance pathway associated with promoter mutations is implicated
in the involvement of nerve cells
in pancreatic cancer.
In this study, we will examine whether glial cells and certain proteins secreted from these cells influence axon regeneration and guidance in the optic nerve in adult mic
In this study, we will examine whether glial cells and certain proteins secreted from these cells influence
axon regeneration and
guidance in the optic nerve in adult mic
in the optic nerve
in adult mic
in adult mice.
In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to
axon guidance.
Several of these are known to be important for neural development
in worms — for example, the gene cle - 1 is needed for
axon guidance.