Sentences with phrase «in axonal transport»

Southern California and joined the Polleux lab in 2011 where he studies the function of LKB1 in axonal transport.

Neurotrophic factors are perturbed in AD and unevenly distributed due to impairment in axonal transport [105].

AGEs impair this axonal transport and alpha adrenergic blockers (acting on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look on the molecular mechanisms of this process (crosslinking of motor proteins in axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.

We study the influence of the Maillard reaction (leading to advanced glycation endproducts, AGEs) on the function of specific proteins which are involved in the axonal transport.

Hayashi and Niwa expect the non-invasive force measurement method to be a strong, new tool in understanding the physical mechanism of neuronal diseases caused by deficits in axonal transport.

Not exact matches

When it is experimentally prevented (either by severing the projecting axons, by treating them with the drug vinblastine, which blocks axonal transport, or by administering 6 - hydroxydopamine, which destroys the nerve endings), the innervating sympathetic neurons in the ganglion die off.

Work in several laboratories has shown that the retrograde axonal transport of NGF follows its interaction with specific receptor sites on the nerve terminals of the newly established fibers.

In my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survivaIn my laboratory, we hypothesize that age - dependent neuronal death occurs partly in response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survivain response to the decline with age, of the process of axonal transport of those critical proteins that are needed for neuronal survival.

The membrane associated adaptor ankyrin - B (AnkB) promotes fast axonal transport and elongation by coupling dynactin to multiple organelles through binding to phosphatidylinositol 3 - phosphate lipids in these cargos.

In the absence of the Aβ challenge, tau reduction had no effect on axonal transport.

Aβ proteins, which build up to toxic levels in the brains of people with Alzheimer's disease, impair the axonal transport of these cargoes.

Specifically, the aims of recent projects were to determine whether axonal cytoskeletal disruption, transport abnormalities, and electrophysiological dysfunction occur prior to RGC death in experimental glaucoma (rodent and non-human primate models) and whether some of these phenomena are detectable by clinically - applicable means.

Brad Fortune, OD, PhD Devers Eye Institute, Portland, OR The Dr. Miriam Yelsky Memorial Research Grant Project: Axonal Transport of Mitochondria: Developing an In Vivo Imaging Assay for Glaucoma Research

(2007) Chronic Minocycline Treatment Decreases Microglial Activation and Improves Retrograde Axonal Transport in Retinal Ganglion Cells in DBA / 2J Retina (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 3291).

(2008) Trpv1 contributes to pressure - induced death and disruption of axonal transport in RGCs (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5481).

Marsh - Armstrong, N., Oglesby, E., Buckingham, B., Horner, PJ., Soto, I. (2007) Molecular Changes in DBA / 2J Retinal Ganglion Cells Coinciding With Axonal Transport Dysfunction (Investigative Ophthalmology & Visual Science, 48: ARVO E-Abstract 5553).

(2010) Target Response to Axonal Transport Loss in Glaucoma (Investigative Ophthalmology & Visual Science, 51: ARVO E-Abstract 2142).

FHV - 1 establishes latency in the trigeminal ganglia and can travel back to the eye via anterograde axonal transport.