Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed
episodes in bipolar I patients stratified by index manic or mixed episode
Low levels of
cortisol in bipolar patients were also associated with depression, low quality of life, obesity, dyslipidaemia and metabolic syndrome.
Lithium can be hard on the body, the study authors said, increasing a person's risk of kidney and thyroid disease, but even that may have a positive
side in bipolar patients.
While fish oil has been shown to prevent relapse and alleviate depressive
symptoms in some bipolar patients, it appears to have no effect on the manic episodes associated with the condition.
Frederick K. Goodwin, MD, a research professor at the George Washington University in Washington, D.C., and a former director of the National Institute of Mental Health, says the current anxieties about the economy are
exacerbated in bipolar patients.
Studies on individual psychotherapy indicate that some interventions may reduce the number of recurrences
in bipolar patients.