Sentences with phrase «in bone»

In 1868, however, the German pathologist Ernst Neumann discovered immature precursor cells in bone marrow, which turned out to be the actual site of blood cell formation, also known as hematopoiesis.

Cells in the bone marrow then pick up the signal and pre-program monocytes with the appropriate function to either protect or repair.

«Biglycan is the first bone matrix protein we've found that plays a role in bone formation,» says NIDR osteoporosis specialist Marian F. Young, who led the study.

Briefly, I study the interaction between cells and the extracellular matrix in bone.

In the bone marrow, blood stem cells give rise to a large variety of mature blood cells via progenitor cells at various stages of maturation.

Vitamin D optimises calcium absorption and therefore plays an essential role in bone mineralisation and skeletal development.

Blood stem cells in the bone marrow have been labeled with a fluorescent marker protein.

High up a Chilean volcano, there's more microbial diversity in bone - dry vents than icy patches - which could alter our search for life out in the solar system

«I started seeing the little holes in the bone that the blood vessels go through,» said Harpel, an amateur fossil hunter who made this discovery in 2012.

He proved it in 2003 by first X-raying mice to kill off all the stem cells in their bone marrow, then repopulating the bone with stem cells tagged with a fluorescent marker.

In MDS, genetic mutations in the bone marrow stem cell cause the number and quality of blood - forming cells to decline irreversibly, further impairing blood production.

So researchers looked at baseline and again 16 weeks later in 70 African - Americans ages 13 - 45 — all of whom had some degree of arterial stiffness — taking varying doses of the vitamin best known for its role in bone health.

The first was isotopes (or forms) of carbon and nitrogen in bone protein, which reflect the diet and local environment in which the fish lived.

«We injected the nanoparticles intravenously, and they found the tumors throughout the body, whether they were in the bone marrow, the spleen or elsewhere.»

By comparing the ratios of uranium and thorium present in the bone, scientists can tell its age.

«We know multiple myeloma cells will anchor into bone marrow, and fat cells in the bone marrow will support the growth and spread of the cancer.

Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

Encased in bone and protected by a special layer of cells, it is shielded from infections and injuries — but also from many pharmaceuticals and even from the body's own immune defenses.

Designed for use in spinal fusion surgery of the lower back, Infuse consists of a titanium cage that houses a collagen sponge soaked in bone morphogenetic protein (BMP), a growth factor that signals bone - forming cells to produce new tissue.

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

As it picks up speed, the pressure waves in its wake become so compressed they ultimately release their energy in that bone - rattling boom.

Although researchers have also detected the parasites in bone marrow, where blood - forming stem cells reside, no one has known until now whether they damage the skeleton.

«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.

But in multiple myeloma, plasma cells grow out of control in the bone marrow, crowding out healthy cells.

Characterized by malignant alterations in the blood - forming stem cells in the bone marrow, ALL is the most common form of childhood cancer.

This work stems from a previous study by Varghese's group to understand how calcium phosphate minerals found in bone tissue induce stem cells to differentiate into osteoblasts.

Scientists from Lawrence Livermore National Laboratory in collaboration with researchers from University of California campuses at Merced and Davis have found that a secreted protein predominantly expressed in bone inhibits prostate cancer metastasis to bone.

Vitamin C may «tell» faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers.

As such, the altered metabolism in the bone cells caused the mice to have a beneficial whole - body glucose turnover and a lean body.

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

The diet increased the levels of leptin — a hormone produced by fat cells that usually signals satiety in the brain — in the bone marrow, which promoted the development of fat cells instead of bone cells.

«Our findings support a theory whereby megakaryocytes and platelets control platelet numbers by «mopping up» excess amounts of thrombopoietin in the bone marrow.

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

The scientists suspected that the lost enzyme might affect the animals» mesenchymal stem cells (MSCs)-- stem cells found in the bone marrow that are capable of developing into both the bone cells and fat cells that make up our skeletons.

Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.

Blood stem cells are found in bone marrow and produce all blood cells in the body.

«The guy looked at it and said, «Do you realize you've got red blood cells in that bone?»»

[Erika Davies et al., Citrate bridges between mineral platelets in bone] And it could inform research into the prevention and treatment of osteoporosis.

That suggests that nutrition has a direct effect on the balance of bone and fat in the bone marrow.

Medical centers around the world now use the Johns Hopkins protocol of post-transplant cyclophosphamide, and Luznik says the inexpensive drug is becoming increasingly mainstream in bone marrow transplant regimens.

Both this molecule and its receptor in the bone marrow could be targeted to prevent the inflammation that occurs with type 1 diabetes,» says co-senior author Dr. Ira Goldberg of Columbia University College of Physician & Surgeons in New York City.

«How common chemo drug thwarts graft rejection in bone marrow transplants.»

In the search for better treatments for this disease the protein Sclerostin, which plays an important role in bone metabolism, is of major interest.

The project's goals were to explore and describe the range of epigenetic changes that take place in bone marrow as stem cells develop into different types of mature blood cell.

The cellular changes in the workers reflected toxicity in the bone marrow, a sign of leukemia, she said.

Vunjak - Novakovic says the researchers are now determining how best to grow blood vessels in bone grafts that can keep them alive.

The six women, who had received continuous denosumab for seven years, had substantial gains in bone mineral density (BMD)-- increasing 18.5 % in the spine and 6.9 % in total hip.

Expertise in bone demineralization, radiation, and psychological issues of long - duration human spaceflight

Participants in the placebo arm had a compensatory increase in bone formation, which was an expected result, but bone formation was flat in the treatment arm.

Osteoporosis results from a loss of bone mass, measured as bone density, and from a change in bone structure.