Sentences with phrase «in brain tumor cells»

In laboratory experiments the researchers mimicked the way SOX9 is stabilized in brain tumor cells and showed how SOX9 turned on 40 to 50 genes in the tumor to make it more resistant to chemotherapy and more prone to spread.

JC Virus T - Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells.

Fredrik Swartling's group at Uppsala University / SciLifeLab and Olle Sangfelt group at Karolinska Institutet have jointly discovered that the usually protective protein FBW7 is commonly mutated and inactivated in brain tumor cells in children.

Known as a PARP inhibitor, the drug acts on a defect in the DNA repair mechanism in the brain tumor cells, they said.

«Scientists identify key defect in brain tumor cells.»

The drug caused a 50-fold increase in brain tumor cell death.

Not exact matches

These CAR - T cells were able to penetrate the blood - brain barrier, one of the major hurdles in treating brain tumors.

Images show tumor cells in a mouse brain at different days.

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alonIn human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alonin mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

Studies suggest that stem cells sustain deadly tumors in the brain — and that aiming at these insidious culprits could lead to a cure

It's also not hard to imagine that what binds you and your friends (and your «Friends») has analogs in ant colonies and beehives, tumor cells and the brain, terrorist groups and spam hosts, the Internet and the electrical power grid.

So far, researchers with the Allen Institute for Brain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve cells, or neurons, taken from the brains of 36 patients as they underwent surgery for conditions such as brain tumors or epilBrain Science in Seattle have described the intricate shapes and electrical properties of about 100 nerve cells, or neurons, taken from the brains of 36 patients as they underwent surgery for conditions such as brain tumors or epilbrain tumors or epilepsy.

In many patients diagnosed with LUAD, tumors cells have already spread to the brain, leading to decreased quality of life and low survival rates.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocyteIn the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytein mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

DIPGs are known as one of the most challenging tumors to treat because cancer cells are intimately intermingled with normal brain cells in a part of the brain that can not be surgically resected.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

«Altered immune cells clear childhood brain tumor in mice.»

«We refer to this as the battle for the brain, in which early on in the disease, the microglia are trying to destroy the brain tumor initiating cells,» says Yong.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

But following the removal of the primary tumor, micrometastatic cells learn to communicate with cells in their new microenvironment in the brain — cells which are, at first, hostile to them.

We found that the inflammation unfortunately gets hijacked by tumor cells that are able to grow faster and penetrate deeper because the blood vessels in the brain are more permeable than in any other part of the body.

Published in Molecular Neurobiology, the study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime - Morawek, Lecturer in Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cCells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cellscells.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

Dr. Del Maestro adds, «Yong and colleagues at the University of Calgary have begun to unravel the complex interaction of the microglia with the brain tumor cells, resulting not only in furthering our understanding, but providing a new concept and drug which can now be immediately assessed in clinical trials.»

«And in this study, we have formally demonstrated for the first time that these cells are compromised in living brain tumor patients.»

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

Nagoya University - led research team shows in mice the potential of a special immune cell that targets a key protein in tumor growth that helps stop brain cancer.

Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

The researchers took this discovery and, in an animal model, identified a drug that is able to re-activate those immune cells and reduce brain tumor growth, thereby increasing the lifespan of mice two to three times.

And how do occasional cells survive in this vulnerable state — sometimes hiding out in the brain for years — to eventually spawn new tumors?

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

Interphone compared surveyed cell phone use in 6,420 people with brain tumors to that of 7,658 healthy people in 13 developed countries — Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden and the U.K. — to try to determine whether people with brain tumors had used their cell phones more than healthy people, an association that might suggest that cell phones caused the tumors.

The cells in such a brain tumor can display very different characteristics, such as varying cell size or number of cell nuclei.

Scientists at Barrow Neurological Institute have recently made discoveries about use of a new technology for imaging brain tumors in the operating room — a finding that could have important implications for identifying and locating invading cells at the edge of a brain tumor.

There is plenty of anecdotal evidence out there claiming a link between cell phone use and cancer: Keith Black, chairman of neurosurgery at Cedars - Sinai Medical Center in Los Angeles, says that the brain cancer (malignant glioma) that killed O. J. Simpson's attorney, Johnnie Cochran, was the result of frequent cell phone use, based on the fact that the tumor developed on the side of the head against which he held his phone.

A team of researchers in northern Europe, however, has now combed through three decades of cancer registries and found no increase in the rate of brain tumors in the five to 10 years following widespread cell phone adoption in that region.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

ICELL8 can isolate up to 1,800 single cells, ranging from 5 μm — 100 μm in size on a single chip, including cells from solid tumors, brain cells, pulmonary airway cells, and multiple cell lines.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

This technique is able to distinguish cancer cell lines with differing metabolic activities and reveals heterogeneous uptake patterns in neurons, mouse brain tissues and tumor tissues with clear cell - to - cell variations.

Subsequent surgery on vaccinated patients has shown that the T cells are finding and killing tumor cells in the brain, but not enough of them.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

«We need to get the [tumor] stem cells to grow in an environment much more like a patient's brain,» he said.