Sentences with phrase «in cell adhesion in»

Structures of water channels AQP0 and AQP4 were analyzed by electron crystallography and appear to play a role in cell adhesion in addition to water channel functions.

This gene plays a role in cell adhesion in the brain.

Not exact matches

A 2012 study found that consuming maltodextrin increased bacterial adhesion to human intestinal epithelial cells and enhanced E. coli adhesion, which is associated with autoimmune disorders and dybiosis in your gut.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

By creating fibrous hydrogels with different levels of crosslinks, the team was able to show that cells surrounded by matrices with fewer crosslinks were better able to draw in fibers and increase the number of focal adhesions around them.

Shenoy and his colleagues were interested in the points where cells actually bond to the surrounding matrix, known as focal adhesions.

The protein, known as focal adhesion kinase, or FAK, activates an enzyme called AKT, which helps islet cells in the pancreas to survive.

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

In contrast, antibodies to the neural cell adhesion molecule (N - CAM) did not inhibit the binding.

In a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migratioIn a new study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migratioin collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1 Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon migration.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

«Virtual tissue technology reveals new drug target in polycystic kidney disease: Advanced computer simulations show that failures of cell adhesion and inhibition cause two types of kidney cyst formation.»

Cells can fail to stick together sufficiently, referred to as reduced cell adhesion, or they can stick together normally but not respond in the correct way to that contact, referred to as a loss of contact inhibition.

This rapid, transmitter - mediated down - regulation of a cell adhesion molecule in the sensory neurons may be one of the early molecular changes in long - term synaptic facilitation.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

When DIXDC1 is blocked or inactivated, focal adhesions become small and numerous, resulting in hundreds of small «hands» that pull the cell forward in response to extracellular cues.

«We can incorporate cell adhesion or degradation sites to recruit cells or draw in different components from native tissue.»

Research groups in Munich, Essen, and Brussels have now detected a highly specific and exceptionally strong variant of this adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the adhesion, in which the bacterial surface molecule HopQ binds itself to so - called «Carcinoembryonic Antigen - Related Cell Adhesion Molecules,» or CEACAMs for short, inside the Adhesion Molecules,» or CEACAMs for short, inside the stomach.

This growth is associated with a down - regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs).

Their studies indicate that the two conditions common in sickle cell disease, dramatically increase red blood cells» adhesion to the lining of blood vessels walls and the debilitating pain crises that can result.

The study also points to a potentially new therapeutic target, the self - adhesion molecule P - selectin, which the researchers found played a central role in increased red blood cell adhesion.

When they restored normal nitric oxide levels by having mice breathe in the short - lived gas — as patients have done in clinical trials — cell adhesion did not increase when oxygen levels decreased.

Among these functions is the transport of lipids and other biomacromolecules between cells via membrane adhesion and fusion — processes that occur in many biological functions, including waste transport, egg fertilization and digestion.

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

In fact, the researchers found gene expression differences between ASD and non-ASD in genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cyclIn fact, the researchers found gene expression differences between ASD and non-ASD in genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cyclin genes related to translation and immune / inflammation functions, as well as cell adhesion and cell cycle.

Now a more fine - grained picture of adhesion mechanics is emerging, thanks to a new tool developed in Illinois in recent years called a «tension gauge tether,» which allows scientists to measure cell mechanics at the single - molecule level.

«This finding reveals cells» ultra-sensitivity for strong single molecule forces in the environment during adhesions,» Roein - Peikar noted.

This week at the Biophysical Society 59th annual meeting, being held Feb. 7 - 11, 2015 in Baltimore, Md., University of Illinois biophysicists are reporting a new picture of cell adhesion mechanics they liken to a famous Hans Christian Andersen fairy tale.

To better imitate cells» real environment in human body, researchers evenly mixed weak (rupture force of 12 pico - Newtons) and strong (rupture force of 54 pico - Newtons) tension gauge tethers and studied cell adhesion in the multiplex scenario.

A team of researchers led by Professor Lindsay Hinck at the University of California, Santa Cruz, examined the ROBO signaling pathway in breast epithelial cells and found that one family member, ROBO1, enhances cellular contractility and stimulates assembly of cell - matrix adhesions.

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

«The Princess and the Pea: Cells» ultra-sensitivity for strong molecular forces in adhesion processes.»

This, in turn, enhanced cellular contractility and adhesion, allowing cells to retain their shape and position within stiff extracellular matrices.

«In our prior studies, tension gauge tethers with different tension tolerances were individually presented to cells, and we found the universal threshold force for integrin - mediated cell adhesion is around 40 pico - Newtons,» Roein - Peikar said.

They found a gene — dubbed Dscam (Down syndrome cell adhesion molecule)-- that appears to give every nerve cell a unique identity during prebirth development, making sure that each cell ends up in the right location in the brain and body.

Cells migrate by connecting their cytoskeleton — a network made up of proteins — to adhesion molecules which in turn get in contact with the surrounding connective tissue.

In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling, cell adhesion and cytoskeleton dynamics required for tumor invasion.

The researchers are still working out the details, but they speculate in the 30 November issue of Cell that entosis occurs due to an imbalance in adhesion forces between two cells when they dislodge from the matrix.

A small percentage of ASD patients carry mutations in genes encoding neuroligins, which are postsynaptic cell - adhesion molecules.

However, Professor Auguste's team, discovered the overexpression of intercellular adhesion molecule - 1 (ICAM - 1) in human TNBC cell lines and tissues, and demonstrated that it is a potential molecular target and biomarker for TNBC therapy and diagnosis.

When the growing nerve fiber and the target cell finally come in contact, the provisional adhesion consolidates into the structural and functional organization of the synapse.

Researchers at the Mechanobiology Institute have comprehensively described the network of proteins involved in cell - cell adhesions, or the cadherin interactome.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

In particular, the research identified several genes regulated by methylation in the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo developmenIn particular, the research identified several genes regulated by methylation in the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo developmenin the egg that are involved in cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo developmenin cell adhesion and migration — both vital properties for cells of the developing placenta in establishing connections with maternal tissues to support embryo developmenin establishing connections with maternal tissues to support embryo development.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

With the E-cadherin interactome now described in detail, researchers can finally step back and view the complex picture that is cell - cell adhesion.

Despite their importance in cell - cell adhesion, scientists have yet to fully understand how the cadherin - catenin - actin complex forms and is regulated.