Sentences with phrase «in cell composition»

This ensures that sister cultures from the same subjects are similar in cell composition and differentiation state, and it avoids the influence of experimental conditions on the differentiation process (1).

We investigated differences in cell composition between blood samples collected pre - and post-mortem.

Not exact matches

Cellular cosmologies are life compositions in that a single cell is likened to a celestial universe, only smaller.

Animals consist of limbs and tissues that are put together in a certain way, and the same goes for the limbs and tissues themselves; they — we should say their cells — have varying compositions.

The composition of your blood also changes, creating a higher ratio of plasma to red blood cells than in non-pregnant women.

The scientists discovered that the two sides of the cell differ in the composition of messenger RNA, or mRNA: About 30 percent of the genes expressed in the intestines produced mRNAs that appeared either on one side of the cell or on the other.

There were clear differences in the composition of immune cells in the wounds and the immune cells present produced higher levels of TGFß at earlier time points.

There are details of the structure of the living cell, essential features in the composition of metals, cotton, silk, rubber, paint, bone, nerve, and a thousand other things which are hidden even from the microscope, and must always remain so hidden because the failure does not lie with the skill of the optician but with the incapacity of light itself.

«Hormone - producing cells are particularly susceptible to perturbed fatty acid metabolism and often have difficulties in regulating their membrane lipid composition.

The shape and chemical composition of these granules is identical to organelles found in cells called melanosomes; these being responsible for creating and storing the pigment melanin.

«Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs,» says co-senior study author Paul Beales, of the University of Leeds in the UK.

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

The researchers then measured cell composition and electrical activity again and found that the cells dramatically changed when they were in contact with neurons from different regions.

They began by characterizing the cell composition, protein expression, metabolism, and electrical activity of neurons from each region in vitro.

Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

Previous work by the researchers developed plasma - activated cell culture medium as a form of chemotherapy, but selected Ringer's solution in the present work because of its simpler composition and likelihood of forming less complex reaction products.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

In addition to quantitative mineralogy, Rietveld refinements also provide unit - cell parameters for the major phases, which can be used to infer the chemical compositions of individual minerals and, by difference, the composition of the amorphous component.

The structure and composition of the erionite from both regions is practically identical, and samples from each place cause mesothelioma - associated changes and inflammation in cell culture and mouse lungs.

The cell walls of the FHB - resistant variety had a particular composition of lignin — a structural component which plays a crucial role in cell wall reinforcement — and showed unique compositions of other structural components including pectin and hemicellulose.

Almost all cells in the human body have identical DNA sequences, yet there are 200 - plus cell types with different sizes, shapes, and chemical compositions.

The researchers observed a periodic variation in the cell's lipid composition, similar to what they noticed in human subjects.

The treatment, which has been tested in animal models, consists of a nanostructured composition encapsulating a protein called interleukin - 2 (IL -2), lethal to cancer cells.

«The information we have gained about the dynamic changes in ECM composition and its interactions with various secreted growth factor proteins enables us to develop new hypotheses for the activation of stem cells in the lung,» explains Dr. Herbert Schiller, first author of the study.

Building on this research, investigators are trying to unravel how vitamin D may protect cells in the colon and the microbial composition of the bacteria, fungi, protozoa and viruses that live on and inside the human body, Moss noted.

Interestingly, isolated islets provide a superior platform for studying propagation of IAPP aggregates because islets retain the composition and organization of endocrine cells and the extracellular matrix, which is absent in isolated, cellular monolayers.

Roswell Park Comprehensive Cancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

And by tweaking the perovskite precursor solution composition, Zhou has been able to make cells in different colors.

These spectra were used in a pilot study to model cell wall sugar composition (Smith - Moritz AM, et al., 2011).

To understand the functions of our body organs in health and disease, it is necessary to study the molecular composition of individual cells that make up the organ's cell communities in the organs.

The European patent, EP 2 800 811, includes claims covering the widely adopted CRISPR - Cas9 single - guide RNA compositions for use in any non-cellular and cellular setting, including eukaryotic cells, such as mammalian, human and plant cells.

We detect such currents in muscles, nerves, secretory glands, and electric organs of fish as well as in plant tissue -LRB-...) It seems likely that all these currents have a similar, if not the same basis, and that their strength and potency depends on the structural conditions and chemical composition of the cells making up each organ.»

Claims cover CRISPR - Cas9 compositions for use in any non-cellular and cellular setting, including eukaryotic cells

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

JAX researchers at the Bar Harbor - based lab's Farmington, Conn., genomic research facility and collaborators in Singapore defined the composition of cancerous cells from 11 colorectal tumors and their adjacent noncancerous cells.

They sometimes study disorders that are not inherited at all, which are due to somatic mosaicism - a difference in genetic composition among cells in an individual.

We build up bio-matrices with defined chemical composition to mimic their environment under physiological and pathological conditions, to supply nutrition, to provide signaling, to create polarized conditions, and to, ultimately, allow us to perform cell - based drug screening in 3D model organs.

These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.

«Using single - cell signatures, colorectal cancers can be further divided into subgroups based on cell - type composition of tumors,» JAX research scientist and paper co-author Elise Courtois, said in a statement.

Moreover, recent data also show that in response to brain damage caused by aging, amyloid deposition, demyelination, and other insults, microglial cells activate several genes, including APOE, in order to more efficiently scavenge and clear tissue debris that are very rich in cholesterol due to the natural composition of the brain, which is mostly made of fats.

We found significant differences in overall cellular composition between pre - and post-mortem blood samples (p < 0.001), the most notable changes induced by death being an increase in resting NK cells and CD8 T - cells, and a substantial reduction in neutrophils (Fig. 7a).

Aging is a systemic process of progressive dysfunction of tissues and organs associated with chronic inflammation, changes in tissue composition and the quality of cells within the tissues.

I enjoyed so much to start thinking in the capability of small things to make a notable difference in biological systems, such as how the properties of the cell membranes are influenced by its chemical composition, and how the food chain is mainly supported by the photosynthesis reaction of plants and algae, which ultimately lead us to survive.

a Cellular composition analysis for 18 cell types shows an increase in NK - cells - resting and T - cells - CD8 and decrease in Neutrophils composition from pre - to post-mortem blood samples.

Microbial mat of the thermal springs Kuchiger Republic of Buryatia: species composition, biochemical properties and electrogenic activity in biofuel cell — Denis Aleksandrovich Yuriev — IOP Conference Series: Earth and Environmental Sciences

However, elevated atmospheric CO2 concentrations and ocean acidification may also have an adverse impact on diatom growth, causing a decrease in cell size and possible further changes in phytoplankton composition.

Assessment of hASC - CM composition found high expression of various human growth factors (IL ‐ 6, 8, 12, eotaxin, IP10, MCP ‐ 1, VEGF, and TIMP ‐ 1) in the supernatant following the co-culture of hASCs with islet cells, while IP10, eotaxin, VEGF, and TIMP ‐ 1 became increased with time during islet co ‐ culture, suggesting the presence of paracrine cross ‐ talk between islets and hASCs.

The researchers found that loss of collagen VII not only affected the composition of the cellular microenvironment but also led to global changes in cell homeostasis on mRNA and on protein level.