Sentences with phrase «in cell cycle regulation»

Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells.

Although the biological mechanisms through which this polymorphism could affect aging are not known, it is adjacent to two genes called CDKN2A and CDKN2B, which play an important role in cell cycle regulation.

Not exact matches

He spent his last year as a Lisbon student studying cell - cycle regulation in yeast at the University of Manchester in the United Kingdom, with an Erasmus scholarship from the European Commission.

Although the regulation of this gene has a strong «cell cycle control» component, I was more interested in studying cell cycle regulation «proper.»

She was on her way out to a pub after a scientific conference when she spotted Paul Nurse, who was working on cell - cycle regulation at Imperial Cancer Research Fund in London.

Such precise regulation of the cell cycle is lost in cancer cells.

When Corry and first author Wen Lu, a graduate student in immunology, sought to determine how the microRNA worked, they found histone deacetylase 4, a protein that plays a role in the regulation of DNA transcription, cell cycle and development.

«We suspect that faults in cell - cycle regulation account for a variety of developmental brain diseases.»

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

Pax - 7 up - regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self - renewal.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).

Polleux F., Dehay C., Moraillon B. and Kennedy H. (1997) Regulation of neuroblast cell - cycle kinetics plays a crucial role in the generation of unique features of neocortical areas.

However, we can not suspect any abnormal effect on parthenotes due to the aberrant expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

The results reveal the central role of protein phosphorylation in the atypical cell cycle regulation of a divergent eukaryote.

After twenty years of research, the cohesin complex still manages to surprise us regularly, as new functions in new areas of cell cycle regulation come to light.

45) * Coe BP, * Lockwood WW, Girard L, Chari R, MacAulay C, Lam S, Gazdar AF, Minna JD, Lam WL (2006) Differential regulation of cell cycle pathways in small cell and non-small cell lung cancer.

In addition to this, the gene duplicates in zebrafish display strikingly different expression during the day - night cycle, presumably to allow efficient regulation of photoreceptor cells under dramatically different light conditionIn addition to this, the gene duplicates in zebrafish display strikingly different expression during the day - night cycle, presumably to allow efficient regulation of photoreceptor cells under dramatically different light conditionin zebrafish display strikingly different expression during the day - night cycle, presumably to allow efficient regulation of photoreceptor cells under dramatically different light conditions.

Methylation, a fundamental epigenetic process whereby carbon groups are attached to DNA to either silence it or promote its expression, is quintessential to cellular processes including detoxification, metabolism, neurotransmitter synthesis, mitochondrial energy production, central nervous system function, cell cycle regulation, cellular integrity, and immune homeostasis — and derangements in methylation have been implicated in many diseases (Robertson, 2005).

EGCg has been scientifically demonstrated to assist in maintaining healthy tissues during times of normal metabolic stress and to support proper cell cycle regulation.

Melanopsin cells in mammals are specialized for measuring ambient illumination, contributing to visual discrimination [8,9], and driving a wide variety of physiological responses including, but not restricted to: synchronization of circadian clocks to light: dark cycles, regulation of pupil size, modulation of sleep and suppression of pineal melatonin production [10 — 14].