Sentences with phrase «in cell entry»

Next, Hafenstein hopes to produce higher - resolution HPV maps to learn more about L2 and its role in cell entry.

Not exact matches

New technology building booms and subsequent collapses are, historically normal and common following the introduction of new and transformative technologies, and we have seen them in the US and British automobile industries, the late 20th century communications «tech wreck», the rise and contraction cell phone manufacturers, and the explosion of entry into US telecommunications post «deregulation» in the US, just to cite a few.

So we can also contemplate this same unfolding and unified purpose of Christ in our own lives, from our conception as a simple cell, ensouled by God in accordance with the Unity Law, to Baptism and entry into Christ in the Eucharist, through the years of growing up and formation in holiness and the spiritual life — maybe through failure and re-conversion.

One day you're checking into the hospital with your soon - to - be-no-longer-pregnant wife and your go - bag and an extra landline phone in case you need to do an interview Mark Wahlberg about his World Trade Center Memorial Competition entry, because cell phones aren't allowed in the delivery room, and the next, your teenager sends you an emoji text from her iPhone urgently requesting you to pick up an extra gluten - free cake pop.

Researchers have noted ever since it was discovered in 1979 that it looks like a molecular crowbar for forcing entry into animal cells.

Dr Daniel Watterson, joint first author of the paper with Dr Jie Li, said that the antibody can block entry to the host cell, an essential step in the virus lifecycle.

Robyn Biti, Graeme Stewart of Westmead Hospital in Sydney, Australia, and colleagues report that they have found an HIV - infected homosexual man whose white blood cells contain a defective copy of a critical surface protein, called CCR5, that the virus uses to gain entry into the cells.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

This allowed him to screen the compounds in his lab at the university using much lower BLS - 2 safety standards, to see if they inhibited viral entry into the cell.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

The drugs block viral entry into cells, the team reports in the June 3 Science Translational Medicine.

Prof. Hasan's group show that a process called SOCE (Store Operated Calcium Entry) which works to maintain calcium levels in cells could also play a role in maintaining the levels of dopamine, a vital neurotransmitter in the brain.

Greber and his team infected human cells in culture with the chemically labeled viruses, and observed the behavior of the viral DNA during entry into cells.

Except, that is, in the brain, where the blood - brain barrier bars both foreign bodies and immune cells from entry.

Researchers at Johns Hopkins have spotted a strong family trait in two distant relatives: The channels that permit entry of sodium and calcium ions into cells turn out to share similar means for regulating ion intake, they say.

When they inserted a fluorescent reporter protein in this virus - like shell, their test became capable of high - speed screening to see which drugs blocked the entry of Ebola - like viral particles into cells as measured by fluorescence.

Scientists pre-treated human liver cells in vitro with SBEL1 prior to HCV infection and found that SBEL1 pre-treated cells contained 23 percent less HCV protein than the control, suggesting that SBEL1 blocks virus entry.

The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and the same type of cells from the lung, heart and bone marrow for the in vivo component.

Gangliosides are lipid molecules that were proposed to play key roles in numerous biological processes, including the formation of raft domains, the entry of toxins into cells and chemical signal reception.

«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.

In cells from sick hearts, these channels often don't inactivate properly, allowing for excess sodium entry and a build - up of calcium, which ultimately promotes abnormal heart rate (arrhythmia) and symptoms of heart failure.

The researchers also found that in nerve cells that detect short sounds, that ability is amplified by electrical properties of the nerve cell membrane's ion channels, which allow the entry and exit of charged chemicals.

They demonstrated that prohibitin found on the surface of motor neuron cells was involved in entry of EV71 into those cells.

In addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the hosIn addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the hosin two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the host.

«In type 2 diabetes, glucose does not enter the cells and increased levels of insulin, resulting from an overburdened pancreas, do nothing to facilitate glucose entry into cells for producing energy,» Martins - Green said.

In addition to providing metabolic support to the expanding tumor population, the newly formed vessels also facilitate tumor cell entry into the systemic circulation (6).

In an elegant set of experiments, Südhof ruled out the possibility that loss of synaptotagmin impairs calcium entry into the cell or hinders some other event peripheral to calcium perception.

FRIEND OR FOE A dengue antibody (blue, shown bound to a dengue virus protein, red, in this molecular model) can ease Zika's entry into cells, a new study finds.

Additional experiments showed the feasibility of creating a two - layer security system for T cells by simultaneously blocking a gene the HIV virus needs to gain entry into cells and a gene the virus needs to survive and reproduce within the cell, resulting in doubly secure resistance.

Liu, K.Q., Bunnell, S.C., Gurniak, C.B. & Berg, L.J. T cell receptor - initiated calcium release is uncoupled from capacitative calcium entry in Itk - deficient T cells.

We began our entry into EM reconstruction with the fly's adult visual system, where much is known about cell types from previous EM and histological studies, as well as ongoing studies in the FlyLight Project.

Research Focus: My research focuses on the role of the herpesvirus entry mediator (HVEM) of by Innate Lymphoid Cells (ILC) and intraepithelial lymphocytes (IEL) in the Intestine.

Hemagglutinin (HA) and neuraminidase (NA) are the two predominant viral glycoproteins found in the viral envelope, and are the primary targets of the host immune system and are key factors in the entry and exit of influenza particles from host cells.

Increasing the stiffness of cancer cell membrane enhanced the entry of polymer nanoparticles through pathways rich in cholesterol.

The SDF - 1 / CXCR4 axis is gaining significant attention mainly due to its important roles in pathological processes, such as HIV entry, tumor metastasis, cell trafficking in autoimmune diseases and inflammatory conditions [10].

Philipp Weissert (Tanaka, MPG)-- «Bmp proteins in urodele myotube cell cycle re - entry and in regeneration» (2008)

Vaxwave ® is based on lymphocytic choriomeningitis virus (LCMV) and in this vector the gene encoding the LCMV envelope protein, normally responsible for virus entry into target cells, has been deleted and replaced with a target gene of interest.

Cyclic stretch decreases TRPC4 protein and capacitative calcium entry in rat vascular smooth muscle cells.

Target - cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes.

«By comparing the cells that are susceptible to HIV entry to those susceptible to HIV infection, we made a surprising discovery,» added Roan, who is also an assistant professor in the Department of Urology at UCSF.

Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells.

This article highlights the need to, as best we can, develop an HIV - 1 Vaccine which targets mucosa such as the GALT which are HIV - 1's main portals of entry in order to prevent latent infection from establishing in stem cells.

The mechanistic complexity of the cascades will be explained using the examples of crucial Cdk1 targets including Sic1, the Cdk1 target and inhibitor controlling the G1 / S transition in budding yeast, and Far1, the molecule defining the decision between mating and entry into cell division.

According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3 - bromopyruvate (3 - BrPA) into malignant cells.

Voltage-gated Ca2 + channels are crucial to the control of Ca2 + entry in neurosecretory cells.

This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B - cell activity.

«Importantly, this analysis helped us identify the protein fibrinogen as the key culprit in MS, by demonstrating how its entry into the brain through leaky blood vessels impacted the health of individual nerve cells.»

A vaccine should tip the balance of this contest in favor of the immune system by increasing the numbers of CD4 + and CD8 + cells that are poised to swing into action if HIV gains entry to the body at some point in the future.

He has been a leader in applying molecular and genetics tools to study the immune system including specification of T lymphocyte lineages, the differentiation of inflammatory T helper cells, the role of microbiota in regulating immune responses, and the mechanisms of HIV entry and pathogenesis.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.