Sentences with phrase «in cell signaling processes»

De novo rational design of molecular scaffolds mimicking protein interactions for specific interference in cell signaling processes: We apply molecular modelling and computer simulation techniques for designing molecules with pharmacological / biotechnological interest.

Not exact matches

Digital Signal Processing Digital signal processing helps make modern cell phones possible.Digital music, digital photos, digital videos: It's easy to forget that we live in a fundamentally analog Signal Processing Digital signal processing helps make modern cell phones possible.Digital music, digital photos, digital videos: It's easy to forget that we live in a fundamentally analog signal processing helps make modern cell phones possible.Digital music, digital photos, digital videos: It's easy to forget that we live in a fundamentally analog world.

The nerve cells involved in this integration process and control of hormonal signals reside in an area of the insect brain known as the mid-Ventral Ganglion (mVG), which in turn communicates with a region of the central brain that is akin to the mammalian hypothalamus.

The paper's lead author — Marcus Yip, who completed his PhD at MIT last fall — and his colleagues Rui Jin and Nathan Ickes, both in MIT's Department of Electrical Engineering and Computer Science, will also exhibit a prototype charger that plugs into an ordinary cell phone and can recharge the signal - processing chip in roughly two minutes.

One clinical trial involves the drug CGF166, a one - time gene therapy, which, if proven successful in humans, could regenerate new hair cells within the cochlea that can signal the part of the brain that processes sound.

This could allow researchers to watch complex processes such as cell signaling in cancerous and noncancerous tissue, according to a study published today in Developmental Ccell signaling in cancerous and noncancerous tissue, according to a study published today in Developmental CellCell.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

A specific genetic marker influences response to therapy in the early stages of RA; a link thought to be due to the gene activating a cell - signalling protein involved in the inflammatory disease process.

In this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinIn this study, the team, which included Dr. Meerim Nurbaeva and Miriam Eckstein in Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin Dr. Lacruz's lab, for the first time used freshly dissected enamel cells (ameloblasts) from rodent teeth to modulate physiological processes in order to understand the contribution of CRAC channels in enamel calcium signalinin order to understand the contribution of CRAC channels in enamel calcium signalinin enamel calcium signaling.

In addition to its known roles in cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioIn addition to its known roles in cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioin cancerous cells, STAT3 also is an essential mediator of cytokine and growth factor signals in normal cells that are important for diverse processes including immunity and inflammatioin normal cells that are important for diverse processes including immunity and inflammation.

Cytokines play a key role in a signaling process that brings immune cells out to fight off an infection.

With careful observation and experiments with mouse oocytes, the precursors of eggs, they've detected molecular signals that create an asymmetry in the machinery that drives meiosis, the cell - division process that gives rise to gametes.

Working with an animal model, the researchers found that a type of cell present in the brain's primary processing area during early development, long thought to form structural scaffolding with no role in transmitting sensory information, may conduct such signals after all.

The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.

«We found that approximately 40 % of the brain cells that process visual signals appear to receive information from mRGCs,» says Brown, whose team reports its work today in PLoS Biology.

Previous experiments have enabled them to decode a signalling pathway involved in adipose cell maturation and to show that calories in the nutrient medium influence this process.

By charting the spinal circuits that process and transmit pain signals in mice, the study, published online November 20, 2014 in Cell, lays the groundwork for identifying ways to treat pain disorders that have no clear physical cause.

Calcium ions are important messengers for the processing of wound signals in plant cells.

These loci are known to be involved in various processes including cell senescence, autoimmunity and cell signaling, and also with Alzheimer's disease.

To address such obstacles, Roybal, now an assistant professor at the University of California, San Francisco and his colleague Leonardo Morsut turned to a signaling molecule on T cells called the Notch receptor, known to be involved in several developmental and biological processes.

His research group focuses on big data network biology, exploring biological systems by developing and deploying algorithms aimed to predict cell behavior, in particular looking at cellular signal processing and decision making.

In prior, unrelated experiments, the same species of worm had become hypersensitive to smell when its nerve cells experienced problems with dopamine signaling, a cellular process that helps control how readily cells can communicate with one another.

In addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processeIn addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processein exciting topics such as signal transduction and cell cycle processes.

A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.

Fu plans to further explore the link between PLK1 and MAPK signaling in prostate cancer patients and determine whether PLK1 - induced EMT contributes to other cancer - promoting processes that go beyond cell migration and metastasis.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

Kong and Crotty's team discovered that ICOS recruits the signaling TBK1 enzyme, which activates certain genes in Tfh cells, thus beginning the whole process of high - affinity antibody production.

Nerves and other electrically - excitable cells communicate with one another by transmitting electrical signals, and sodium channels play a vital role in this process.

For example, switches based on the optical force could be used to speed up the routing of light signals in fiber - optic cables, and optical oscillators could improve cell phone signal processing.

Several long - lived worms carry mutations in a gene involved in a process that appears to use chemical signals to trigger activities inside cells.

Gangliosides are lipid molecules that were proposed to play key roles in numerous biological processes, including the formation of raft domains, the entry of toxins into cells and chemical signal reception.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune responsIn their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step - by - step process that results in a precisely tailored and effective immune responsin a precisely tailored and effective immune response.

Although reactive oxygen species can damage cells when produced in high amounts, according to a study published online Sept. 5, 2017 by Science Signaling and featured on the journal's cover, these oxidative species are crucial signals that start the process of repairing myofiber.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

They receive and process signals from the retina's light - detecting cells, the rods and the cones, and transmit them to another set of cells that, in turn, transfer the information to the brain.

As stated in the paper, «Biological machines consisting of cells and biomaterials have the potential to dynamically sense, process, respond, and adapt to environmental signals in real time.»

«It appears there is cross-talk between pathways called calcium channels in sensory nerve cells that process the itch signal.»

When the team added TGF - β1 to cells lacking FOX01, the cells behaved normally and produced the proper suite of molecules needed for healing, indicating that FOX01 acts upstream of TGF - β1 in the signaling pathway triggered during the healing process.

Chen said proving that the channels work in concert helps explain how sensory cells can process numerous types of environmental signals, including itching that results from different things.

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

In studying the functional behavior of the brain, from control of muscles to the formation of memories, scientists are using such tools such as electron microscopy, recordings of electrical signals from individual brain cells, and imaging of brain structures and processes using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and high - resolution optical imaging.

Some of the cells in this layer (the photoreceptors) convert light into an electrical signal that is then amplified and processed by other cells before being sent to the brain via the optic nerve.

«And it's an important first step in advancing wireless signal processing and designing ultrathin, efficient cell phones.

Like many biological processes, it involves an entire sequence of molecular signals that result in the formation of new cells and tissue.

The complete list is: the Food Research Center; the Center for Research, Teaching, and Innovation in Glass; the Center for Research and Development of Functional Materials; the Brazilian Research Institute for Neuroscience and Neurotechnology; the Center for Research on Inflammatory Diseases; the Center for Research and Innovation in Biodiversity and Drug Discovery; the Center for Research on Toxins, Immune Response, and Cell Signaling; the Research, Innovation and Dissemination Center for Neuromathematics; the Center for Research in Mathematical Sciences Applied to Industry; the Obesity and Co-Morbidities Research Center; the Center for Cell - Based Therapy; the Center for Metropolitan Studies; the Human Genome and Stem - Cell Research Center; the Center for Computational Science and Engineering; the Center for Research on Redox Processes in Biomedicine; the Center for the Study of Violence; and the Optics and Photonics Research Center.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

Traditional hydrogels made up of either synthetic polymers or natural biomolecules often serve as passive scaffolds for molecular or cellular species, which render these materials unable to fully recapitulate the dynamic signaling involved in biological processes, such as cell / tissue development.

The system can help scientists determine more about how a cell reacts to its immediate environment, Bissell says, and how that process goes wrong in growing or spreading tumors, in which cells lose their ability to read signals from their environment that would prevent them from dividing.

Biology is rife with examples of modularity: the overwhelming majority of molecules in a cell is either part of an intracellular complex with modular activity, such as the ribosome, or participates in an extended (functional) module as a temporally regulated element of a relatively distinct process (e.g., signal amplification in a phosphorylation ‐ mediated signaling pathway).

In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19In addition to p53, there are other transcriptional activatory mechanisms that are not well understood for the most part and which operate in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19in response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of cell differentiation processes (18, 19).