Sentences with phrase «in cell studies»

In cell studies, SGC0946 reduces H3K79 dimethylation with an IC50 of 2.6 nM in A431 cells and 8.8 nM in MCF10A cells.

The new gadget should smooth out some of the complexities involved in cell studies of drugs, says Schmid.

«The next step is to test tandem therapy in cell studies, because it makes sense to combine an mTOR inhibitor with an agent that does kill cancer cells,» Dr. Morita said.

It works in cell studies and in mouse studies, but so far has proved frustratingly ineffective in human patients.

The author of evolution did set the conditions for which his THEORY would not work — conditions that have now been met, with the advances in cell study.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

Not exact matches

Regarding intensity, a study published in PLOS ONE found that workout intensity was not affected for individuals talking on the phone, compared to those not using a cell phone, but when it came to texting, workout intensity was significantly lower.

A great study done in 2010 indicated that drinking fat - free milk immediately after whole - body resistance training and again one hour after the workout allowed participants to increase fat loss, gain greater muscle and strength, and strengthen bones by reducing bone cell turnover.

A series of preliminary Mayo Clinic studies conducted in 2010 showed promise for the potential use of a chemical component of green tea (epigallocatechin gallate) in reducing the number of cancer cells in patients with chronic lymphocytic leukemia.

Available epidemiologic studies in humans have «not shown clear evidence of a relationship between cell phone use and cancer,» according to the National Cancer Institute, although this remains a topic of debate among researchers.

«In everyday interactions with significant others, people often assume that momentary distractions by their cell phones are not a big deal,» another researcher involved in the study, Meredith David, saiIn everyday interactions with significant others, people often assume that momentary distractions by their cell phones are not a big deal,» another researcher involved in the study, Meredith David, saiin the study, Meredith David, said.

Studies show spending time among trees boosts the number of «killer cells» in the immune system that are key to beating infections and fighting cancer.

The majority of study participants reported that it's all good, fine and kosher with them (well, technically «generally OK») to use a cell phone when walking down the street, riding public transit and waiting in line.

«If you're vulnerable and isolated, the more important that cell phone becomes for you,» says Mark Latonero, a fellow at the Data & Society Research Institute in New York, who has studied technology and human trafficking.

The study found an increased risk of cardiac schwannoma, a tumor type that typically originates from cells found in neurons.

For a small study published in March in the journal Aging Cell, researchers looked at 125 amateur cyclists aged 55 to 79, comparing them with 75 people of a similar age who rarely or never exercised.

«We suspected that the young are most vulnerable because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to genetic mutations in human cells.

Pagan said that a larger, more comprehensive study must be done before determining the drug's true impact, but if the drug's effectiveness is confirmed in such tests, nilotinib could become the first treatment to impede the killing of brain cells that's consistent with Parkinson's, according to NPR.

«This technology will allow us to paint a whole chromosome and look at it live and really follow it... as it goes through developmental transitions, for example in an embryo,» study co-author Rebecca Heald, a molecular and cell biologist at UC Berkeley, said in a statement.

Previous studies have shown that playing popular cell phone and video games for at least 10 minutes a day may help players improve their game scores or their success in moving from one level to the next.

In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.

About half of the patients in a Kymriah study got cytokine - release syndrome, a response to the reprogrammed cells running loose in the body.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

April 16 Merck & Co's immunotherapy Keytruda plus chemotherapy significantly improved overall survival versus chemotherapy alone in newly - diagnosed patients with advanced non-small cell lung cancer in a highly - anticipated study that appears to cement the company's lead in the most lucrative oncology market.

JCAR015 is a CD19 - directed chimeric antigen receptor technology (CAR - T) product candidate that has been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.

Juno is developing its immunotherapy product candidate, JCAR017, which is in a Phase I trial, studying patients with B - cell Non-Hodgkin Lymphoma [NHL].

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

February 2, 2017 By Ann Perry http://mbd.utoronto.ca/ When Arif Aziz learned last fall about a new independent study project that was bringing together MBA candidates and PhD students in health sciences and engineering to map the global market for stem cell therapies, he jumped at the opportunity.

Lie4Him, Schweitzer, one of the first scientists to use the tools of modern cell biology to study dinosaurs, has upended the conventional wisdom by showing that some rock - hard fossils tens of millions of years old may have remnants of soft tissues hidden away in their interiors.

A team led by David Sinclair of the University of New South Wales published a study in Cell, saying that they have actually reversed mice's aging process.

These were not studies published in fly - by - night oncology journals, but blockbuster research featured in Science, Nature, Cell, and the like.

It is a kind of «missing link» in the study of life's emergence, demonstrating how nucleated cells first appeared.

His dissertation was to be on the god Eros, but it remained unwritten, as, in addition to his studies, Stern was busily involved in organizing revolutionary cells and obtaining weapons.

The fastest growing and largest churches in the world are cell - based, with all of the church ministry flowing out of small groupings of people who meet weekly, worshiping together, studying together, praying together and often engaging in highly imaginative service to people in their neighborhoods.

«Garcia - Falgueras and Swaab state in the abstract of their 2010 study, «The fetal brain develops during the intrauterine period in the male direction through a direct action of testosterone on the developing nerve cells, or in the female direction through the absence of this hormone surge.

However, embryonic stem cells remain the «gold standard,» and studies of all types of stem cells should continue in parallel for the foreseeable future.»

In the late 1550s two Protestant «cells» were uncovered in Valladolid and Seville and new laws were passed almost immediately strengthening censorship and forbidding students to study abroaIn the late 1550s two Protestant «cells» were uncovered in Valladolid and Seville and new laws were passed almost immediately strengthening censorship and forbidding students to study abroain Valladolid and Seville and new laws were passed almost immediately strengthening censorship and forbidding students to study abroad.

«Garcia - Falgueras and Swaab state in the abstract of their 2010 study, «The fe - tal brain develops during the intraut - erine period in the male direction through a direct action of tes - tosterone on the developing nerve cells, or in the female direction through the absence of this hor - mone surge.

Studying the Bible in his cell, he was struggling to understand what the apostle Paul meant in his letter to the Romans: «For in the gospel the righteousness of God is revealed — a righteousness that is by faith from first to last, just as it is written: «The righteous will live by faith»» (1:17).

Dennis has a PhD in genetics / developmental biology from the University of British Columbia and a special interest in studying pattern formation and cell - cell communication during tissue development using fruit flies as a model organism.

Kauffman was trained as a physician, but gave up medical practice to study fundamental questions in biology: «I entered biology because the magnificent wonder of cell differentiation overwhelmed me» (HU94).

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

The objects of his study range from a class of molecules that have the basic self - duplicating property of living things, through cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control by impersonal laws of nature.

Even an individual cell in our bodies is a responsive entity whose behavior can be studied in tissue culture.

The high - grade organisms we study in biological evolution contain many subordinate enduring objects; molecules and cells, for example, comprise the environment for atoms and electrons in our bodies.

High dosages of reb A fed to rats reduced sperm production and increased cell proliferation in their testicles; however, another study using rats and humans demonstrated lack of reproductive toxicity.

Some studies even show that there are compounds in fermented cabbage that promote healthy cells.

One preliminary cell study by researchers at Sejong University in South Korea found that piperine may impact fat cells.

In the case of MRSA, studies show that the bacteria forms a septum through the middle, creating to separate cells.

«Animal studies and in - vitro studies with human cells have repeatedly shown that food - grade carrageenan causes gastrointestinal inflammation and higher rates of intestinal lesions, ulcerations, and even malignant tumors.»