Sentences with phrase «in cells cultured»

VASA was detected earlier in cells cultured in testicular cell - conditioned medium than in those cultured in non-conditioned medium or in ovarian cell - conditioned medium, suggesting that the initiation of germ cell differentiation in testicular cell - conditioned medium was faster than that in ovarian cell - conditioned medium.

Based on a 3D image such as an MRI scan, Aspect's machine builds relatively complex organic structures out of a «hydrogel» embedded within cells taken from the body and grown in a cell culture.

3M Delivers Early Purification with New Hybrid Purifiers, Single - use functionalised media provides scalable purification performance in cell culture

After testing in cell culture one (AbD09097) showed the favoured activity to neutralize Sclerostin.

In cell culture, low concentrations of these corrector molecules can reduce mitochondrial impairment and neuronal dysfunction.

Finally, in cell cultures and animals, overexpressing the hormone could produce something that looks like cancer, and that would shrink when treated with an IGF - 1R blocker.

Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells» resistance to paclitaxel.

The researchers then examined a number of DNA variants in the protein production - control region of the bellwether gene in cell cultures.

In addition, they found that PD - L1 blockade increased virus production in the cell culture from such patients.

A few drugs have shown promise in cell culture or animal models, but clinical trials in humans are time consuming because of the slow onset and progression of the disorder's clinical symptoms.

They discovered three chemical structures with potent antiviral activity against Ebola virus in cell culture.

There will be several rounds of recruitment, and «specifically at this time, we are accepting applications for both junior / senior postdoctoral researchers and recent graduates wishing to enroll in our Ph.D. program as well as personnel with extensive expertise in cell culture and one expert in flow cytometry to fill in the position of manager of the flow - cytometry platform.»

The team found several hundred that might do so and restore the protein to its functional shape; more than 30 did the job when tested in cell culture, although they don't know whether they attached to p53 in the pocket.

«It's well known in IVF clinics that if you have high glucose concentrations in cell culture, it favours survival of male blastocysts,» says Mathews.

In cell culture, high expression levels of GPR161 induced proliferation of mammary epithelial cells, disrupted the acinar structures formed by these cells, and enhanced their invasive capacity.

The study, in cell cultures and mice, tested a new approach of targeting stromal cells and cancer cells simultaneously.

Last spring the team reported that their fibers induced the formation of new blood vessels in both cell cultures and living animals.

In 2011, researchers led by David Baker, a computational biologist at the University of Washington in Seattle, created a designer protein that binds HA's stem, which prevented viral infection in cell cultures.

Genomic RNA editing and its impact on Ebola virus adaptation during serial passages in cell culture and infection of guinea pigs

The bacterium produced an antibiotic, dubbed lugdunin, which killed a slew of superbugs in cell cultures and mice with no signs yet of growing resistance.

In both cell cultures and mice, these mineralized viruses proved to be significantly more infectious — and deadly — than the native viruses.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

Currently, most influenza vaccines in the United States are produced using chicken eggs, while a few are made in cell culture or by using recombinant DNA technologies.

But it's hard in cell culture — and even harder in the body — to smuggle bulky PNAs across cell membranes.

Glutamine addiction has often been studied in cell culture systems that are genetically altered to overproduce c - MYC, a central regulator of growth and proliferation in all cells that is frequently de-regulated in cancers.

In the cell culture systems, c - MYC protein will always be at a high level.

However, this coupling does not exist in cell culture models with exogenously expressed c - MYC — the type of systems that are mainly used to investigate glutamine addiction in cancer.

Previous studies in cell culture have indicated that cell - to - cell infection may help HIV to resist antibodies and potent therapies.

Cellular toxicity was unrelated to the type of «carrier» solution used in the cell cultures, the use of HES made from different origins (potato versus corn starch), or the time cells spent in culture with HES.

«To put this into perspective, reprogramming to induced pluripotency in cell culture takes several days to weeks whereas reprogramming to totipotency in zygotes occurs in less than 24 h,» says Kikuë Tachibana - Konwalski, who devotes her laboratory's research to understanding the molecular secrets of egg cells and zygotes.

«The fact that glutamine addiction has mainly been investigated in cell culture systems may have overestimated the lethality of glutamine deprivation,» said Martin Eilers, University of Würzburg, who led the study together with Kempa.

The implications were hardly lost on the Bethesda crowd: If the virus was transmitted in cell cultures in Ruscetti's lab, it could also be contaminating the nation's blood supply as a result of blood donations from unknowingly infected donors.

To date, the researchers have tested the function of their activation - ready sensor in cell culture of human kidney and cancer cells.

You can look for efficacy in cell cultures, but that tells you almost nothing about what's going to happen when you test in a mouse or a human.

The researchers ran numerous experiments in cell cultures and mice to observe what happened to Salmonella in the inflamed gut when these genes were mutated.

«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.

Their study, which appears as a letter in the Sept. 8 edition of Nature Medicine, expands on work published in April showing that a combination of ribavirin and interferon - alpha 2b stops MERS - CoV from replicating in cell culture.

Dr. Islam saw this phenomenon occur in cell culture and in some samples from patients with head and neck cancers.

«Next steps may include efforts to grow these viruses in cell culture and functional analyses to assess their risk of being transmitted to primate hosts.»

In another study published this week the group investigated influenza pH1N1 virus - host cell interaction in detail and found that certain host function could be temporally inhibited with small molecule MK2206 to block influenza infection in cell culture.

The next task will be to engineer neurons in cell cultures so that they manifest one or more of the variants.

The current work, she explains, uses antibodies that were generated and characterized at CNDR previously to see if they would reduce the pathology both in cell culture and in animal models.

Together, Raman says, this dual - mode treatment produced cell - killing results that paralleled their experiments in cell cultures.

Studies by Bausch and others have also detected live Ebola virus in sexual fluids that can successfully grow in cell culture, suggesting it could also lead to infections in other individuals.

To find out if the new viruses actually cause disease, researchers can try to grow them in cell culture and infect animals with them.

In the West, these have been replaced by safer, more effective vaccines grown in cell cultures.

But the development of nanoparticle carriers has been slowed by the challenges of testing them, first in cell culture to identify promising nanoparticles, and later in animals.

Critically, despite the detection of enhanced Zika infection in cell culture models using antibodies from macaques previously exposed to either yellow fever or dengue and then exposed to Zika, there were no signs of enhanced Zika infection seen in these macaques themselves.

Now in the future they would love to be able to use the person's own cells — let's say scar repair later — but for the short - term applications these would be commercially available cells that are kept in cell culture ready to go.

The researchers activated the TRPV1 receptor in the cell culture with capsaicin or helional, by adding the substances to the culture for a period of several hours or days.