Sentences with phrase «in cells infected»

To this end, we have developed a reporter construct that generates a fluorescent signal specifically in cells infected with dengue (DENV).

By stymieing three genes in cells infected with HIV, researchers stop the virus from spreading to other cells

In July labs at the University of California at San Francisco, University of Massachusetts Medical School, and MIT reported that they had used RNA - interference to arrest viral replication in cells infected with HIV and polio.

Not exact matches

In mice, norovirus infects rare cells in the lining of the gut called tuft cellIn mice, norovirus infects rare cells in the lining of the gut called tuft cellin the lining of the gut called tuft cells.

«But in this case, when this virus infects cells, the virus makes its own transcription factors, and those sit on the human genome at lupus risk variants (and at the variants for other diseases) and that's what we suspect is increasing risk for the disease.»

Jason Mills, a gastrointestinal pathologist at Washington University School of Medicine in St. Louis, envisions growing thousands of such organoids, each from a different person's cells, and infecting them with a pathogen to study the role of individual genetics.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alonIn human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alonin mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

Several physical measurements, including electron microscopy, assured us that our product was a closed loop coiled tightly around the virus - DNA template and that it was identical in size and other details with the replicative form of DNA that appears in the infected cells.

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

«Scientists find potential mechanism for deadly, sepsis - induced secondary infection: Sepsis disrupts immune cell recruitment to infected skin in mice.»

The study found that in infected cells, about 35 per cent of the peroxisomes had disappeared.

It suggested, he notes, how some HIV strains could be blocked from infecting cells and offered data that could help in the interpretation of the Thai results.

In such patients, a phenomenon called «antibody - dependent enhancement» (ADE) takes place, during which antibodies that were generated during the first infection bind but do not destroy the slightly different newly infecting virus, but instead facilitate its infection of immune cells.

The team found that the number of gamma delta T - cells was higher in the CMV - infected babies, and that a greater proportion of these immune cells were activated.

«How highly contagious norovirus infection gets its start: Virus infects rare intestinal cells in mice; findings point to therapeutic strategy.»

Combing the genetic data from a transmission study in ferrets, a team led by Thomas Friedrich, a professor of pathobiological sciences at the University of Wisconsin - Madison School of Veterinary Medicine, found that during transmission, when one animal is infected by another through sneezing or coughing, the process of natural selection acts strongly on hemagglutinin, the structure the virus uses to attach to and infect host cells.

Now, researchers at Washington University School of Medicine in St. Louis have shown, in mice, that the virus infects a rare type of intestinal cell called a tuft cell, so named because each cell sports a cluster of hairlike extensions on its surface.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

«This raises important questions about whether human norovirus infects tuft cells and whether people who have chronic norovirus infections and continue to shed the virus long after infection do so because the virus remains hidden in tuft cells,» Wilen said.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

«In a single mouse, for example, maybe 100 cells will be infected, which is very few compared with other viruses such as the flu.»

Somewhere along the way, certain molecular changes, including a deletion of 29 base pairs from the original virus, allowed SARS to infect and replicate in human cells.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

In principle, scientists can modify AAVs to infect some cell types more than others to deliver their therapeutic payloads where they are most needed.

Both Zika strains were able to infect and cause cell death in neural progenitor cells.

However, how this microbe replicates in the infected cells remains a mystery.

«We hypothesized that individual mutations in viral genes could be expected to have a range of effects on the virus's ability to replicate, to infect new cells and escape the immune system,» Carlson says.

Both viruses were used to infect muscle cells in the hind legs of mice that had muscular dystrophy.

In preclinical studies, oncolytic herpes simplex viruses seemed especially promising, as they naturally infect dividing brain cells.

The Boston patients, in contrast, are free of the virus thanks to a combination of a bone marrow transplant plus continuing antiretroviral drugs to stop newly donated immune cells from being infected.

«The best explanation for what we are seeing is that frequently, after exposure to HIV, a few cells in the genital tract are infected, without establishment of a systemic infection,» says senior investigator Eric Hunter, PhD, professor of pathology and laboratory medicine at Emory University School of Medicine, Emory Vaccine Center, and Yerkes National Primate Research Center.

The paper, in PLOS ONE, spells out how virologist David Evans at the University of Alberta in Canada, and his research associate Ryan Noyce ordered bits of horsepox DNA from the internet, painstakingly assembled them, then showed that the resulting virus was able to infect cells and reproduce.

University of Melbourne Professor, Leann Tilley, an Australian Research Council Laureate Fellow at the Bio21 Institute, tested the new drug in red blood cells infected with parasites and found that it was as effective at killing the artemisinin resistant parasites as it was for the sensitive parasites.

An unknown component of breast milk appears to kill HIV particles and virus - infected cells, as well as blocking HIV transmission in mice with a human immune system.

«We have shown that Anc80 works remarkably well in terms of infecting cells of interest in the inner ear,» says Stankovic, an otologic surgeon at Mass..

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

The production of this protein in a nerve cell eventually kills it but it has long been thought that this protein can not spread out of the cell and infect and kill neighbouring ones.

The virus, redesigned using sophisticated protein engineering techniques, works: With its shield and its adapter, these viral gene shuttles efficiently infected tumor cells in laboratory animals.

Robyn Biti, Graeme Stewart of Westmead Hospital in Sydney, Australia, and colleagues report that they have found an HIV - infected homosexual man whose white blood cells contain a defective copy of a critical surface protein, called CCR5, that the virus uses to gain entry into the cells.

Roughly half of the 2,000 molecules tested include FDA - approved molecules used to prevent viral replication in infected cells.

All cells are shown in blue while virally infected cells are stained in green.

Researchers led by Andreas Plueckthun, professor at the Department of Biochemistry at the University of Zurich, have now succeeded in rebuilding the viruses so that they effectively recognize and infect tumor cells.

After 381 days, this cow's antibodies prevented 96 percent of the 117 HIV types from infecting cells in a lab dish.

Human immunodeficiency virus - type 1 (HIV - 1) replicates actively in infected individuals, yet cells with intracellular depots of viral protein are observed only infrequently.

A host can often be infected with more than one type of virus and, as viruses replicate in the host's cells, the genetic segments of the progeny viruses can be shuffled into new combinations.

«One has to collect a lot of cells to measure the latent reservoir,» Richman says, noting that fewer than one cell in a million is latently infected.

In the body, MHCI proteins are watchdogs, tagging infected cells for immune attack.