Sentences with phrase «in cells of the pancreas»

So the liver starts trying to offload the fat by dumping it back into the bloodstream in the form of something called VLDL, and that starts building up in the cells of the pancreas that produce the insulin in the first place.

Not exact matches

Using the gene - editing tool CRISPR - Cas9 to turn off certain genes in a mouse zygote as well as other new techniques to enrich the pluripotent stem cells of a rat, the group managed to grow various rat organs (a pancreas, heart, and eyes) in a mouse embryo.

Then they would inject human stem cells into the pig embryo in hopes that the human stem cells would bridge the gaps of the missing pancreas gene and form a human pancreas.

This type of diabetes strikes in the early teenage years and begins with the immune system destroying the cells in the pancreas that produce insulin, according to Patrick Holford, founder of the Institute for Optimum Nutrition in London.

It is often caused by the destruction of the insulin - producing cells of the pancreas resulting in an insulin deficiency.

Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans) cells in the pancreas.

Eventually, Lim hopes that reprogrammed cells will measure glucose levels in the pancreases of diabetics and trigger a biological insulin response, or even cure cancer.

Over the past 15 years, the GFP gene has enabled scientists to watch a plethora of previously murky biological processes in action: how nerve cells develop in the brain, how insulin - producing beta cells form in the pancreas of an embryo, how proteins are transported within cells, and how cancer cells metastasize through the body.

«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again — the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.

Four years ago, the research team of Pedro Herrera (University of Geneva) first cast doubt on this assumption when they demonstrated that a few alpha cells in the pancreas of genetically modified diabetic mice changed into beta cells.

This leads to high blood glucose values; the function of the insulin - producing cells in the pancreas is also negatively influenced.

In this type of diabetes, the body destroys insulin - producing cells in the pancreas, resulting in high blood glucose levelIn this type of diabetes, the body destroys insulin - producing cells in the pancreas, resulting in high blood glucose levelin the pancreas, resulting in high blood glucose levelin high blood glucose levels.

Although Herrera's group has investigated the versatility of pancreatic cells in mice, several observations in diabetic patients suggest that the human pancreas is capable of transformation too.

Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta cells in the pancreas.

In the intestines of diabetic rats, they found that GLP - 1 triggered some gut cells to become more like those that manufacture insulin in the pancreaIn the intestines of diabetic rats, they found that GLP - 1 triggered some gut cells to become more like those that manufacture insulin in the pancreain the pancreas.

The four children also had more of the types of species that are known to trigger gut inflammation, a possible prelude to type - 1 diabetes, in which the body's immune system mistakenly produces antibodies that attack and destroy the beta cells of the pancreas that normally make insulin.

Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing cells in the pancreas.

«Studying human islet cells has been a major challenge in the field of diabetes research for decades because the pancreas essentially digests itself shortly after a person's death,» said professor of developmental biology Seung Kim, MD, PhD.

The findings, which will be published April 28 in Cell Metabolism, highlight the importance of two genes not previously implicated directly in pancreatic function, and show that the pancreas continues to develop and mature during the first decades of life.

Studies in mouse models suggest that BL - 9020 can inhibit beta cell death in the pancreas, thus preventing full maturation of Type 1 diabetes.

Medicines used to treat diabetes fall into four groups: those that stimulate the pancreas to put out more insulin; those that lower insulin resistance in cells; those that help the body use insulin; and those that slow down or block the breakdown of starches, which in turn keeps blood - glucose levels lower.

In type 1 diabetes, the pancreas stops making insulin, the hormone that facilitates absorption of glucose from the blood into cells.

In type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreaIn type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreain the islets of the pancreas.

If the finding that resident memory T cells are the most potent mediators of immunity holds up in different types of cancer, which I think it will, you could take a biopsy of the lung or the pancreas, for example, to see if there are resident T cells there.

The overproduction could attack the insulin - producing cells of the pancreas and trigger diabetes, she wrote in the June 6 Journal of Proteome Research of the American Chemical Society.

Naidoo is also senior author of a follow - up study in Aging Cell this month that shows, for the first time, an effect of sleep deprivation on the UPR in peripheral tissue, in this case, the pancreas.

Just as in pregnancy, the cells in the pancreas that are responsible for the production of insulin change.

The work, funded by national charity Pancreatic Cancer Research Fund, uncovers new evidence that PAK4 plays a key role in enabling cancer cells to grow and to spread from the pancreas into other areas of the body, a process called metastasis.

In the case of type 1 diabetes, it destroys the insulin - producing cells in the pancreas, and in multiple sclerosis it strikes the central nervous systeIn the case of type 1 diabetes, it destroys the insulin - producing cells in the pancreas, and in multiple sclerosis it strikes the central nervous systein the pancreas, and in multiple sclerosis it strikes the central nervous systein multiple sclerosis it strikes the central nervous system.

This is a faint echo of what happens inside the body of someone developing diabetes: Their T cells are activated against cells in the pancreas much as they would be against a foreign invader, like a virus.

The mutant mice produced less insulin — the hormone made in the pancreas that helps cells burn sugar — and they were plump and diabetic, with high levels of glucose in their blood.

The most intriguing mutant type of mice were unusually thin; they generated more active osteocalcin, secreted more insulin, and produced many times more of the insulin - releasing cells in the pancreas.

Douglas Melton, codirector of the Harvard Stem Cell Institute in Cambridge, Massachusetts, and his colleagues study both the stem cells that develop into the pancreas and its insulin - producing cells and the genes that guide those cells» development.

Furthermore, the normal ductal cells that are able to develop into pancreatic cancer represent about 10 percent of the cells in the pancreas, complicating efforts to pinpoint the changes that occur as the tumor develops.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

In an online issue of Cancer Discovery, the scientists described the molecular steps necessary for acinar cells in the pancreas — the cells that release digestive enzymes — to become precancerous lesionIn an online issue of Cancer Discovery, the scientists described the molecular steps necessary for acinar cells in the pancreas — the cells that release digestive enzymes — to become precancerous lesionin the pancreas — the cells that release digestive enzymes — to become precancerous lesions.

As such, scientists hypothesise that cathelicidins may be involved in the control of type 1 diabetes, an autoimmune disease where certain cells in the immune system attack beta cells in the pancreas which secrete insulin.

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

Gobbling a slice of sweet pumpkin pie, for instance, causes beta cells in the pancreas to secrete insulin, a hormone that allows the uptake of glucose and most amino acids into the tissues.

In the strongest test of their potential yet, six people with heart failure will be treated in France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCIn the strongest test of their potential yet, six people with heart failure will be treated in France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCin France with a patch of immature heart cells made from hESCs, and 40 people with diabetes in the US will receive pouches containing immature pancreas cells made from hESCin the US will receive pouches containing immature pancreas cells made from hESCs.

When pancreas cells containing clumps of misfolded IAPP, taken from an engineered diabetic mouse, were mixed in a dish of healthy human pancreas cells, it triggered the clumping of IAPP in the human cells.

GREEN GLOB - LINS Spurred by a dose of misfolded proteins, a 20 - week - old mouse developed clumps of deformed proteins (green) in a cluster of cells called an islet (red) in its pancreas.

These are organized in germ layers and are thus the origin of different tissue types, including the pancreas and its insulin - producing beta cells.

The researchers, therefore, wanted to study whether the vaccine also increased the risk of developing autoantibodies against beta cells in the pancreas and the occurrence of type 1 diabetes.

Accounting for about 1 percent of all pancreatic cancers, pNET is a cancer of the endocrine cells, known clinically as the islets of Langerhans, which exist in small clusters throughout the pancreas.

Image of non-diabetic healthy human islet cells that reside in pancreas.

«Our stem cells also survive outside of mice, in a culture, so we can also manipulate them in a laboratory,» said Abad, adding that: «The next step is studying if these new stem cells are capable of efficiently generating different tissues such as that of the pancreas, liver or kidney.»

A ONE - OFF treatment for diabetes is a step closer thanks to a better understanding of how human liver cells can be transformed into something like the beta cells that produce insulin in a healthy pancreas.

* In type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cellsIn type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cellsin the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cells).

Ron McKay and his colleagues at the National Institute of Neurological Disease and Stroke in Bethesda, Maryland, usually focus on brain development, but they were intrigued by recent papers reporting that some pancreas cells express nestin, a protein typical of developing neural cells.