UB researchers have pinpointed important changes
in cellular behavior that occur in Pemphigus Vulgaris, the rare, blistering skin disease shown in this microscopic image.
However, due to technological limitations, previous genetic studies largely focused on mixed populations of cells, obscuring critical nuances
in cellular behavior.
Not exact matches
Using what is called «calcium reporters,» researchers were able to see the neurons firing up inside the worm and record the changes
in cellular activity during the egg - laying
behavior.
So
in 1974, he headed south to Tulane University
in New Orleans, Louisiana, for graduate training
in physiological psychology: the study of how the brain influences
behavior at the neurochemical and
cellular levels.
And once I got into brain biology, it became clear you needed to study the brain on the
cellular level, and once you began to understand aspects of
behavior in the
cellular level, you wanted to understand the molecular level.
The sea slug was the model organism for Kreiner's thesis research, which explored how
cellular mechanisms mediate simple
behaviors and led to a publication
in Science.
At the
cellular level, these disorders are associated with heightened activity
in the basolateral amygdala (BLA), which is known to play a central role
in emotional
behavior.
The changes
in cellular structure and
behavior were the opposite of what Xu - Friedman team's saw
in a previous study that placed mice
in a consistently noisy environment.
White is interested
in human
behavior, but said humans are difficult to study at the
cellular and synaptic level.
«
In this way, modern supercomputers allow millions of small timesteps of atomic motions to be simulated, getting us to examine the protein but also
cellular membrane
behavior on the microsecond timescale.»
His research group focuses on big data network biology, exploring biological systems by developing and deploying algorithms aimed to predict cell
behavior,
in particular looking at
cellular signal processing and decision making.
In the past decade, researchers have used mouse models to unravel how cellular changes in the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavio
In the past decade, researchers have used mouse models to unravel how
cellular changes
in the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavio
in the nucleus accumbens (NAc), a brain structure involved
in action selection associated with arousal and reward, may contribute to addiction - related behavio
in action selection associated with arousal and reward, may contribute to addiction - related
behavior.
These data indicate that
cellular metabolic communication plays a critical role
in addiction - related
behaviors, which may have implications for new strategies to prevent cocaine addiction.
«Our findings fit with the growing appreciation of the importance of a cell's structural and biochemical surroundings
in influencing
cellular behavior.
A multicellular marine animal without organs, Trichoplax's feeding
behavior may include
cellular coordination, resulting
in external food digestion, according to a study published September 2, 2015
in the open - access journal PLOS ONE by Carolyn Smith and colleagues from the National Institute of Health
in Bethesda, MD..
Their observation provides a better understanding of cytoskeletal self - organization
in general, which may
in turn lead to better drug design and new materials that can mimic
cellular behaviors.
Systems biology provides better methods of drug discovery: research teams can measure changes
in genetic activity, protein levels and
cellular behavior of the immune system
in response to a potential vaccine.
Those data were then combined with information about functional changes
in cell
behavior to develop a nanomechanical profile, or phenotype, for specific
cellular states.
Due to these crucial roles
in regulating normal
cellular behavior, redox status has been recognized as a key area of biological research
in various diseases, including cancer.
«What we found at the
cellular level correlates with the
behaviors we saw
in the less - anxious, hyper - active mice, which means having overactive pyramidal neurons with their brakes removed could be contributing to these
behaviors,» says Zhu.
More broadly, he said, «These findings are part of an emerging theme that there is a whole spectrum of diseases that includes ALS, and some forms of dementia and myopathy, that are caused by disturbance
in the
behavior of these structures that perturbs
cellular organization.»
Researchers are building a substantial understanding of the biophysical, molecular, and
cellular interactions of neurons, but directly relating those interactions to outward
behaviors is an ongoing challenge
in the field.
Scientists injected fluorescent molecules into about 150 mouse brain structures and used a high - resolution microscope to document the molecules as they moved through the brain's «
cellular highways,» which need to be
in tip - top shape for different parts of the brain to communicate and coordinate
behaviors.
Once they had achieved this precise control over the
cellular interactions
in the brain, they turned to exploring
behavior: Mice that are less fearful are more likely to venture farther than others.
Previous work by Fredberg and colleagues had documented the importance of collective
cellular behavior in asthma, showing that cells comprising epithelial tissues — which line the surfaces of all organs throughout the body — can unjam and flow like a fluid, or jam and freeze like a solid.
Dr. Chartoff's Neurobiology of Motivated
Behavior Laboratory, founded
in 2009, investigates the molecular, biochemical, and
cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.
The goal is to not only provide broadly applicable experimental tools but also help transform the way
in which we think about single cells, cell - cell interactions, diseased
cellular states and therapeutics so as to create a new paradigm for understanding and designing systems - level
cellular behaviors in multicellular organisms.
Although some of the key molecular components involved
in the formation of
cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the
behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the
behavior of large structures and tissues.
These results complement
cellular and physiological data and show that dopamine at encoding promotes the prioritization of events
in memory, with implications for understanding the role of memory
in adaptive
behavior.
As a
cellular biologist Dr. Pilar Sanchez Gomez has been interested
in the molecular mechanisms that control adult neural stem cell (NSC)
behavior.
Grillner's experimental and theoretical analysis of motor coordination
in the lamprey has served as a standard for other attempts to describe the circuits that encode vertebrate
behaviors in precise
cellular and anatomical terms.
Since it is still beyond the reach of even the most sophisticated
in vitro methodology to simulate the complex interplay of physical,
cellular, biochemical, and other factors that influence cell
behavior in microvessels and interstitial tissues, we make use of intravital microscopy.
identify molecular,
cellular, and anatomical similarities
in how these molecules work across species that represent the fundamental principles through which brain neurochemistry affects social
behavior in vertebrates.
«
In neuroscience, there is a huge black box between genetic information and
behavior,» said Krogan, who is also the director of the Quantitative Biosciences Institute and a professor of
cellular and molecular pharmacology at the University of California, San Francisco (UCSF).
In my lab, we explore the molecular, cellular, and behavioral mechanisms through which two types of molecules, sex steroids and neuropeptides in the vasopressin / oxytocin family, act within those circuits to influence social behaviors associated with reproductio
In my lab, we explore the molecular,
cellular, and behavioral mechanisms through which two types of molecules, sex steroids and neuropeptides
in the vasopressin / oxytocin family, act within those circuits to influence social behaviors associated with reproductio
in the vasopressin / oxytocin family, act within those circuits to influence social
behaviors associated with reproduction.
«Vertical integration of gene function» describes how gene expression initiates a series of biochemical,
cellular, and physiological changes that ultimately culminate
in an observable
behavior.
The level of detail gained
in this work was, and still is, unique
in that it allows the observation of changes
in behavior caused by changing occurring at the
cellular and network level.
The
cellular mechanisms underlying this bursting
behavior have been studied
in vitro, using either acute slices of the adult hypothalamus, or organotypic cultures of neonatal hypothalamic tissue.
The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological
behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning
cellular energy pathways
in the brains of people suffering from this disease.
''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the
cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes
in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of
behavior (cognitive decline).
The concentrated antioxidants found
in this amazing red fruit can actually promote and support proper
cellular behavior when abnormal cells begin to wreak havoc
in the body, especially for men.
At the
cellular level, consider the voltage-gated
behavior of the sodium channels
in a nerve axon or the «negative damping» of hair cells
in the cochlea.
In 1998, the Progressive Insurance company started a pilot program in Texas, in which drivers received a discount for installing a GPS - based device that tracked their driving behavior and reported the results via cellular phone to the compan
In 1998, the Progressive Insurance company started a pilot program
in Texas, in which drivers received a discount for installing a GPS - based device that tracked their driving behavior and reported the results via cellular phone to the compan
in Texas,
in which drivers received a discount for installing a GPS - based device that tracked their driving behavior and reported the results via cellular phone to the compan
in which drivers received a discount for installing a GPS - based device that tracked their driving
behavior and reported the results via
cellular phone to the company.
- Improved support for Motorola Moto G Dual SIM: — QS: adjusted network mode tile (allows changing SIM slot on long - press)-- QS: adjusted handling and reordering of
cellular tiles — QS: proper adjustment of signal tile size for tiles per row option — Signal cluster adjustments, including icon coloring (NOTE: cell signal doesn't support data activity indicators)-- fixed Smart radio — all other misc Multi SIM related adjustments - Quick settings: — revived Ringer Mode Tile (silent == priority)(thanks to romracer)-- revived USB Tethering Tile — fixed other misc issues
in tile management (thanks to romracer)- BatteryBar: improved
behavior in lock screen status bar (now allows bottom position)- ProgressBar: improved
behavior in lock screen status bar (now allows bottom position)- Phone: — added workaround for missed calls notification LED — added 5s ramp - up duration for ascending ringtone - Ultimate notification control: — fixed issues causing unexpected heads up and notification icon «jumping» — show package names
in app descriptions for better identification of packages having the same app name - Power: improved option for low battery warning policy - Navigation bar: improved handling of cursor control keys - Recents: added option for using alternate icon for clear all button - Fixed unexpected disappearing of centered clock and centered traffic monitor - Other misc Motorola specific fixes (thanks to romracer)- Updated Japanese translations (thanks to WedyDQ10)- Updated French translations (thanks to ch - vox)- Updated Hungarian translations (thanks to benjoe1)- Updated Chinese (Simplified) translations (thanks to liveasx)- Updated Portuguese (BR) translations (thanks to wyghor, KingKaminari)- Updated Russian translations (thanks to gaich)- Updated Chinese (Traditional) translations (thanks to PeterDaveHello)- Updated Malay translations (thanks to zamzameir)
This is learnable and can grow
in us, as our
behaviors are constantly training our nervous systems, even on a
cellular level.