Sentences with phrase «in cellular differentiation»
Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.
http://www.scilifelab.se/ Not exact matches
Vitamin A plays important roles in vision, cellular differentiation, growth, reproduction and immune - competence.
Up until now, however, it has been unclear what comes first during cardiomyocyte differentiation: the reorganization of the DNA's folding in the cellular nucleus or the DNA's methylation — and whether these mechanisms are dependent on one another.
The authors explain in the article that NSD1 mutation has recently been linked in the scientific literature to the blocking of cellular differentiation and the promotion of oncogenesis in this type of tumor.
Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.
This cellular differentiation takes place exactly as Alan Turing predicted it would in his 1952 paper, «The Chemical Basis of Morphogenesis.»
«Our findings indicate that metabolites alone appear to be able drive many of the key changes in cellular function and differentiation,» Ruohola - Baker said.
Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.
The central problem in pattern formation is how can genetic information be translated in a reliable manner to give specific spatial patterns of cellular differentiation.
Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
The new paper is «by far the most complete survey of a cellular differentiation event,» says Juha Kere, a molecular geneticist at the Karolinska Institute in Stockholm, who is not affiliated with the FANTOM group.
The new cellular and molecular data uncovered in the current study will be «exploited in the future to further improve liver bud organoids» and «precisely recapitulate differentiation of all cell types» in fetal human development, the authors write.
Special focus is placed on Rho - kinase inhibition, relating to its potential to promote and support extracellular matrix production in cultured chondrocytes and its role in fibroblast cells as a part of direct chemical cellular differentiation.
The CCP is engaged in numerous multidisciplinary projects in other model systems (e.g. fly, zebrafish, yeast) that aim to determine how complex molecular circuits function and evolve in response to genetic and environmental changes, cellular differentiation, evolution and disease.
Secondly, before considering the use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion, reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic cellular mutations and teratoma, or tumor formation, in the patient.
He studies the molecular mechanisms by which female steroid hormones such as estrogen control development, differentiation, cellular proliferation and survival in hormone - responsive tissues and cancers.
Wnt / beta - catenin signaling is a tightly regulated, multi-functional pathway involved in in many cellular processes, including cellular decisions about proliferation versus differentiation.
As cellular junctions are one of the first specialized structures that form during tissue development they have a critical role in guiding cell polarization and differentiation.
Applying these paradigms on various neural differentiation schemes of human pluripotent stem cells allows us to identify and isolate new types of neural stem and progenitor cells, to characterize their cellular properties and molecular foundations, to expose their progenitor origin and track their imminent potential, to reveal their in vivo counterparts and learn about their regenerative potential.
In eukaryotes, a homeobox encodes a protein domain (the homeodomain) which can bind DNA that act as part of transcription factors to switch on cascades of other genes that induce cellular differentiation by initiating the cascades of coregulated genes required to make individual tissues, organs, or body parts.
Sphingosine -1-phosphate is a potent signaling lipid involved in numerous biological functions including, cellular proliferation, survival, migration, invasion, differentiation, architecture, immune cell trafficking, angiogenesis and vascular integrity.
Comparing leaf development and cellular differentiation in the C3 species rice to that in the C4 species maize mainly using large scale comparative protein (proteome) analysis.
Basic research on cellular and molecular properties on stem cells in giving new insight on their homing, engraftment, differentiation and biological effects.
- Synthesis of specific inhibitors of beta - catenin The progressive accumulation of nuclear beta - catenin, which deregulates cellular proliferation, differentiation, and migration, is an initial event in the development of colonic tumorigenes.
Through genome - wide profiling we find that 5 - 46 % of the variation in different iPS cell phenotypes, including differentiation capacity and cellular morphology, arises from differences between individuals.
Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of abnormal tumor stem cell differentiation (9).
Results: We discovered stable epigenetic signatures which define regional differences in gut epithelial function, including induction of segment - specific genes during cellular differentiation.
Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted, via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased production of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an estrogen receptor beta (ERβ) ligand that promotes normal cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer.22, 23, 24
In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or osteoblastic differentiation.
PQQ is a co-factor compound for a special class of enzymes involved in cellular function including cellular growth, development, differentiation, and survival.
The key is to not suppress your immune system with PUFA and maintain sufficient vitamin d levels such that you have proper cellular differentiation and don't get cancer in the first place because your immune system knows how to fight it.
The vaccinated Purdue dogs also developed autoantibodies to laminin, which is involved in many cellular activities including the adhesion, spreading, differentiation, proliferation and movement of cells.
Unlike normal plasma cells, the malignant plasma cells look large and round with a high mitotic index (measure of the proliferation of a cell population) in early stages of cellular differentiation.