Sentences with phrase «in cellular dysfunction»

Enhanced amyloidogenic processing of APP by the ß - site APP cleaving enzyme (BACE) and the γ - secretase complex and reduced clearance lead to increased intracellular levels of soluble oligomeric Aß, resulting in cellular dysfunction comprising e.g., synaptic failure, mitochondrial dysfunction, enhanced oxidative stress, neurotransmitter and neurotrophin depletion, inflammation, and apoptosis which is reflected in patients as clinical symptoms such as cognitive deficits [2, 3].

Not exact matches

During this clinically silent period, however, there may be indicators of dysfunction on a cellular level, such as the elevated levels of S100B antibody found in the cerebral spinal fluid in the football players in the study, even six months after the end of the season, which he said, could «potentially herald -LSB--RSB- the early stages of [chronic traumatic encephalopathy] or CTE.»

One reason group A Streptococcus and other invasive pathogens are so dangerous is they release pore - forming toxins that can poke holes in the membranes of cells within a person's body, leading to cellular dysfunction or cell death.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction.

Recent large - scale efforts have launched a new generation of studies that aim to identify the molecular and cellular characteristics of the brain and how these translate into normal brain function — or, in the case of disease, dysfunction.

In many degenerative diseases, including neurological, metabolic, genetic, and inflammatory diseases, it's thought that the accumulation of misfolded proteins leads to cellular dysfunction and death.

The goal of our research is to better understand the cellular and molecular mechanisms involved in neuronal and synaptic dysfunctions characterizing neuropsychiatric diseases.

We will seek investigators that span a range of metabolism expertise, with an emphasis on interdisciplinary and collaborative - minded researchers passionate about exploring the basic molecular and mechanistic underpinnings of cellular metabolism and its dysfunction in human disease.

Low levels of the naturally occurring protein progranulin exacerbate cellular and cognitive dysfunction, while raising levels can prevent abnormalities in an Alzheimer model

We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching > 15 % of all cells in very old individuals.

These data indicate that cellular senescence is causally implicated in generating age - related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.

SAN FRANCISCO, CA — A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria — the brain's cellular power plants — can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

Would ketosis hurt ya or help ya... Completely depends on why you're hypothyroid... for instance, if you're hypothyroid because of stress / cortisol dysfunction, then chances are your reverse T3 (rT3) has been upregulated thus displacing free T3 (at the cellular level) in an effort to slow you down and get you recovered.

Remember the «upstream» cause of type two diabetes is the fats in the diet which cause insulin resistance and cellular mitochondrial dysfunction.

In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or osteoblastic differentiation.

But defects of the DNA repair system in brain cells could contribute to the accumulation of potentially disruptive and toxic metabolites of cellular insult, and lead to neurological dysfunction.»

Identification and correction of these metabolic abnormalities, including leptin resistance and cellular thyroid dysfunction, can result in dramatic long term successful weight loss.

However, the metabolic theory of cancer proposes that some cancers are caused by a dysfunction of cellular respiration and that the restriction of glucose in the.

The end result of the hydrogenation process is a completely unnatural fat that causes dysfunction and chaos in your body on a cellular level...... your body doesn't know what to do with it.

It is usually an excess of cellular damage that isn't all that relevant in normal aging - any sort of global dysfunction in cells will tend to share high level similarities with aging, even if the damage is different.