Sentences with phrase «in cellular models»

Here, Anna presents how studies of neural stem cells and neurons derived from iPS cells of patients show faithful mimicking of known disease phenotypes in our cellular models of disease, like Alzheimer's disease, autism, and Down syndrome.

Salk scientists create new molecular scissors to correct protein imbalance in cellular model of dementia

This study is the first to investigate the phenotypic effects of the HAT activator CTPB, and to demonstrate that p300 / CBP HAT activation has neurotrophic effects in a cellular model of PD.

A small molecule activator of p300 / CBP histone acetyltransferase promotes survival and neurite growth in a cellular model of Parkinson's Disease

A study of UK law firms by property organisation CBRE found a clear differential between open plan and cellular: 310 sq ft occupied per fee earner in open - plan offices compared to 550 sq ft per fee earner in a cellular model.

Not exact matches

Speaking to CNBC, Apple Chief Executive Tim Cook said the Apple Watch with cellular data service is «sold out in so many places around the world» and iPhone 8 models were also sold out.

We combine artificial intelligence with automation to conduct experimental biology at scale — testing thousands of compounds on hundreds of cellular disease models in parallel.

They then tested the contributions of samples from breast milk as well as individual molecules in both animal and cellular models of infection, measuring the length of time until resolution.

The disruption of prenatal cellular activity in zebra fish, which share 80 percent of their genes with humans and are considered a good model for studying human brain development, seemed to result in hyperactivity, according to the Canadian study, which was published Monday in the Proceedings of the National Academy of Sciences.

The researchers found that the immune cells in the skin of this animal model generated large amounts of the cytokine IL - 17 — a protein of the immune system that activates cellular inflammation in response to damage.

They used this novel simulation approach to build a model of a sperm cell that demonstrates cellular movement from individual dynein protein molecules in the tail all the way up to the whole cell, allowing them to observe how changes at the atomic level are reflected in larger - scale structures.

In this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorIn this new study published in Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumorin Nature, Alexandra Van Keymeulen and colleagues used state of the art genetic mouse models to identify the cellular origin of PIK3CA and p53 induced breast tumors.

The scientists are testing the ability of drugs already on the market to reverse this cellular transformation in the pancreas in mice models of human pancreatic cancer.

Now, in this week's issue of the Proceedings of the National Academy of Sciences, Thomas Albright and Ricardo Gil - da - Costa of the Salk Institute for Biological Studies describe a model system that completes the bridge between cellular and human studies of schizophrenia, an advance that should help speed the development of therapeutics for schizophrenia and other neurological disorders.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

While scientists could do cellular work in animal models on the role of dopamine versus glutamate, and they could do EEGs in human beings, a bridge between the two remained elusive.

The sea slug was the model organism for Kreiner's thesis research, which explored how cellular mechanisms mediate simple behaviors and led to a publication in Science.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

Using cell - based model systems and Drosophila, they found CRMP1 overexpression reduces hungtingtin aggregation and cellular toxicity, while reduced CRMP1 results in increased aggregation and toxicity.

The report, which drew heavily on two Environmental Protection Agency (EPA) workshops held in 1995, also recommends more research on such topics as DNA biomarkers that can gauge an organism's exposure to endocrine disruptors; models for predicting how endocrine disruptors are metabolized; mechanisms of how endocrine disruptors act at a cellular level; and the effects of mixtures.

In the dominant deafness model, gene therapy with a related gene, TMC2, was successful at the cellular and brain level, and partially successful at restoring actual hearing in the startle tesIn the dominant deafness model, gene therapy with a related gene, TMC2, was successful at the cellular and brain level, and partially successful at restoring actual hearing in the startle tesin the startle test.

The next step in this line of investigation, already in development, is to learn how cellular responses vary, on a molecular level, among roots of flooded plants when the hormone is not present, which would make it possible to create a response model where this signaling path would play a key role.

Using this approach, researchers can easily generate diseaserelevant isogenic models to determine the impact of correcting or introducing disease - relevant mutations on cellular phenotypes in a tissue - appropriate context.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

These models can be used to explore the cellular role of PCSK9 in vitro and to test the efficacy of cholesterol - lowering agents.

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.&raquIn recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.&raquin vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

Those tests don't give us the details we need to understand the nature of the pathology at the cellular level, so we modeled the disease to perform a systematic analysis of the optic nerve, from its origin in the eyes to termination in the brain.»

Dr. Marc Baum, the lead scientist at Oak Crest and co-author of the work, stated «this model is unique as it faithfully recreates the vaginal environment ex vivo, both in terms of the host cellular physiology and the associated complex vaginal microbiomes that could not previously be cultured.

Bearden says she and her team are collaborating with other scientists to investigate brain structural differences in animal models, to find out what causes them at the cellular level.

Drosophila serves as a model organism that helps geneticists to decode the molecular fundamentals of cellular biology and unravel mechanisms that are conserved in human beings and other vertebrates.

In the past decade, researchers have used mouse models to unravel how cellular changes in the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavioIn the past decade, researchers have used mouse models to unravel how cellular changes in the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavioin the nucleus accumbens (NAc), a brain structure involved in action selection associated with arousal and reward, may contribute to addiction - related behavioin action selection associated with arousal and reward, may contribute to addiction - related behavior.

When this model was in its softest mode, normal (benign) mammary epithelial cells behaved normally within it, forming cellular structures referred to as acini that capture many key features of the normal in vivo mammary epithelium.

His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the model organisms studied at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.

Analyses were performed on the frog Xenopus laevis, an animal model widely used by researchers from around the world to study laws governing cellular division in depth.

Scientists use it as a model organism for studying cellular signals, disease, and the movement of cells in response to a chemical stimulus (chemotaxis).

Researchers from the Institute of Neuroscience at the Universitat Autònoma de Barcelona have discovered the cellular mechanism involved in memory consolidation and were able to develop a gene therapy which reverses the loss of memory in mice models with initial stages of Alzheimer's disease.

To create a more realistic mouse model of low MD activity, the team devised a new method that uses a virus to embed into the surface of MD neurons receptors that block cellular activity in the presence of a compound called clozapine - N - oxide.

The scientists from the universities of Heidelberg and Chicago (USA) used optogenetics and mathematical modelling to identify a central molecule in cellular mechanics.

If the work proceeds as expected, «all interactions between genes, proteins, and small molecules will be revealed, and the whole cellular network will be reconstructed,» says Igor Goryanin, who heads cell modeling at GlaxoSmithKline in Stevenage, U.K.

Bone loss in models of leptin or leptin receptor deficiency has been linked with lower osteoblast activity (9, 14), suggesting that cellular leptin resistance in obesity might reduce bone formation.

Together with her colleagues Margaret MacGibeny, an M.D. / Ph.D. student, then - postdoctoral researcher Ian Hogue, and Lynn Enquist, the lab's principal investigator and the Henry L. Hillman Professor in Molecular Biology, Koyuncu has used this unique latency model system to reveal specific cellular and viral components that can prevent the infection from going to sleep.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

However, because J - Lat cells divide autonomously and possess other aberrations associated with cellular transformation, cytosine methylation was analyzed in a recently developed primary cell model of latency [43].

To achieve such integration, Tara Oceans is driven by researchers with expertise in biological and physical oceanography, ecology, microbiology, systematics, molecular, cellular and systems biology, bioinformatics, data management, and modeling.

Dr. Chartoff's Neurobiology of Motivated Behavior Laboratory, founded in 2009, investigates the molecular, biochemical, and cellular mechanisms underlying drug dependence and withdrawal using animal behavioral models with high relevance to the human condition.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Construction of genetic models continues to be a most effective measure in understanding gene functions because loss of functional mutants accurately reflects non-redundant protein functions and elucidates the cellular impact of a protein of interest.

Finally, the HZI will help develop in vivo imaging technologies to characterize (i) vaccine biodistribution and persistence, and (ii) cellular and molecular changes at the injection site and in draining lymphoid tissues, helping to refine the use of animal models.

Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.