Sentences with phrase «in cellular regulation»

We also have research interests in cellular regulation by ADP - ribosylation, which links epigenetics to metabolism; lipid kinases; and sphingolipid biosynthesis, which has strong links to both inflammation and cancer, and where mutations in the various proteins involved are associated with a variety of rare diseases.

Analysis of endogenous small RNAs indicated that a fraction derive from a biosynthetic mechanism that is similar to that of secondary siRNAs formed during RNAi, suggesting that small antisense transcripts derived from cellular messenger RNAs by RdRP activity may have key roles in cellular regulation.

Not exact matches

Regulation is also starting to play a bigger role, as regulators explore cellular agriculture as a viable food source in the future.

Although no functions could be assigned to three of the proteins, bioinformatics analysis suggested that the remainder are involved in a wide range of biological processes, including reproduction, cellular metabolic processes, multicellular organismal growth, developmental processes, growth, locomotion, response to stimuli, localization and biological regulation.

Hackermüller: «This finding gave rise to a lively discussion as to whether this could be caused by chance events or mistakes in the regulation of cellular processes.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

But in the study being published, researchers at the Department of Cell and Molecular Biology at Karolinska Institutet present a molecular time mechanism that can help explain neuronal stem cell regulation and therefore also the occurrence of cellular diversity in the brain.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

The major goals of this project are to determine the combined influences of light and gravity on plant development through the identification of changes in the mechanisms and regulation of essential cellular functions.

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

While normal RNA regulation involves regulated and reversible assembly of RNA - protein particles, both increased cellular age and mutation push the process towards hyperassembly, which leads to altered pools of RNA or RNA regulatory proteins in neurons that contribute to their eventual death.

We are looking for candidates interested in combining experimental and theoretical approaches to study the regulation of protein oxidation at molecular and cellular levels.

The second scientist I'd like to meet would be the late Harold «Hal» Weintraub, who was a pioneer in cellular reprogramming and mechanisms of gene regulation.

Understanding the molecular connections between the local regulation of subcellular homeostasis and axon morphogenesis is therefore a critical challenge in cellular neurobiology.

These include methods for deconvolution in fluorescence microscopy as applied to cellular morphogenesis, in addition to methods for live - cell binding measurements using fluorescence recovery after photobleaching (FRAP), fluorescence correlation spectroscopy (FCS) and single molecule tracking (SMT) as applied to transcription factor regulation.

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

Dr. Coyle's group used the SR - / - mouse model to explore the role of glutamatergic transmission in the regulation of 5 - HT2AR - mediated cellular and behavioral responses.

Shorter patient survival was generally associated with up - regulation of genes involved in mitosis and cell growth, and down - regulation of genes involved in cellular differentiation.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

Although some of the key molecular components involved in the formation of cellular structures and tissue formation are known, we currently lack a bottoms up understanding of how the behavior of these molecules gives rise to the formation of large structures, partly because of the lack of tools for both studying the spatial regulation of soluble proteins and biophysically characterizing the behavior of large structures and tissues.

Two - pore domain potassium channels (K2P) play a central role in the control of cellular excitability and the regulation of the cell's electrical membrane potential.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium / phosphate homeostasis.

The isoforms of this histone play complex regulatory roles in several cellular processes — epigenetic regulation of gene expression, selective regulation of developmental genes, and telomere maintenance — that could contributed to tumor growth and progression if dysregulated.

From 2009 to 2012 she collaborated with the Laboratory of Integrated and Oncohematology Diagnostics and cellular Manipulation in «V. Cervello» Hospital in Palermo, in which she carried out her intership and her thesis work entitled «Loss of heterozygosity (LOH) and regulation of miRNAs in acute myeloid leukemia with deletion of 7q».

However, whether ABL kinases have a role in the regulation of cellular processes critical for metastasis, other than invasion, has not yet been evaluated.

As we gain a deeper understanding of the cellular regulation mechanisms of Tau function, we will shed more light on the complex role of Tau in the aetiopathogenesis of neurodegeneration.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

You are correct that stem cells are regulated by the Center for Biologics Evaluation and Research (CBER) as human cells, tissues and cellular and tissue - based products (HCT / Ps) under the authority of Section 361 of the Public Health Service (PHS) Act, and the implementing regulations in Title 21 of the Code of Federal Regulations (CFR) Part 1271 (see http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/RegulationofTissues/ucm150485.htm and http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/QuestionsaboutTissues/ucm136323.htm for more inregulations in Title 21 of the Code of Federal Regulations (CFR) Part 1271 (see http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/RegulationofTissues/ucm150485.htm and http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/QuestionsaboutTissues/ucm136323.htm for more inRegulations (CFR) Part 1271 (see http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/RegulationofTissues/ucm150485.htm and http://www.fda.gov/BiologicsBloodVaccines/TissueTissueProducts/QuestionsaboutTissues/ucm136323.htm for more information).

Researchers have uncovered a connection in the network of checks and balances underlying cellular iron regulation.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

A subclass of ncRNA transcripts are encoded by highly regulated, multi-exon, transcriptional units, are processed like typical protein - coding mRNAs and are increasingly implicated in regulation of many cellular functions in eukaryotes.

The focus of the Mar lab is to understand how variability in gene expression contributes to the regulation of cellular phenotypes.

102, 103 One proposed mechanism thought to mediate these effects is an up - regulation of cellular stress resistance in response to ER, which may occur via a process called hormesis.

Also noted by IER studies are an increase in the expression levels of silent mating type information regulation 2 homolog 1 (SIRT1), an NAD + - dependent deacetylase.20 The expression of SIRT1, also increased by prolonged ER in rodents, is linked to the up - regulation of cellular stress resistance and improved outcomes in animal models of metabolic, neurodegenerative and inflammatory diseases.106, 107These findings have been suggestively accompanied by improvements in resilience to disease progression in rodent models of Type 1 diabetic nephropathy 20, survival following induced ischaemic injury 21 and a reduction in oxidative stress.105

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

NAD + is present in many key cellular functions, from metabolic processes to circadian rhythm regulation to energy production.

Methylation, a fundamental epigenetic process whereby carbon groups are attached to DNA to either silence it or promote its expression, is quintessential to cellular processes including detoxification, metabolism, neurotransmitter synthesis, mitochondrial energy production, central nervous system function, cell cycle regulation, cellular integrity, and immune homeostasis — and derangements in methylation have been implicated in many diseases (Robertson, 2005).

• Help regulate oxygen uses and energy production • Important in nerve, muscle and cellular functions • Play a vital role in cognitive function, including memory and mood • Involved in regulation of metabolism, body temperature, blood sugar and insulin control, thyroid function, carbohydrate metabolism and control over hormonal processes • Lubricate joints and improve mineralization of bones • Help transport cholesterol • Improve digestion of the gut • Build the immune system and regulate inflammatory response • Can help direct the processes that stimulate fat breakdown and utilization • Helps regulate blood pressure

You'll learn practical ways to apply this science immediately through the MELT Hand and Foot Treatments — and how these simple self - treatments can improve your body's ability to restore balance and support cellular repair and regulation, which can create remarkable, lasting changes in just a few minutes a day.

Although these findings are intriguing, the cellular regulation of skeletal muscle proteolysis in response to negative energy balance and manipulations in dietary protein is not well described.

Of particular importance is the BCAA leucine, a potent independent stimulator of muscle protein synthesis in cell culture and animal models through enhanced cellular regulation of mRNA translation (29).

These changes to the regulations make sense to me — I have often felt that if the cellular phone in my pocket had the power to mess with an aircraft to the point that the electronics were disrupted putting the people on board in danger, it would be a little ridiculous that they allow those devices on board at all.

After graduation, he served as a postdoctoral research fellow in the prestigious John B. Pierce Laboratory and department of cellular and molecular physiology at Yale University School of Medicine, where he investigated the effects of exercise and diet on gene regulation in muscle tissue.

My first suggestion is to get involved with organizations that are advocating for «smart regulation» and not just preserving the status quo like the telecom companies tried to do in blocking cellular.

The Governor also announced today that he will increase the penalty for using a cellular phone without a hands - free device or a handheld device while driving from two to three points through changes in state regulations.