Sentences with phrase «in cellular toxicity»
The authors demonstrated that these compounds inhibit the transport of a broad range of key MRP4 substrates, and that they are low in cellular toxicity and highly stable.
http://www.abcam.com/ Not exact matches
The cellular changes in the workers reflected toxicity in the bone marrow, a sign of leukemia, she said.
Using cell - based model systems and Drosophila, they found CRMP1 overexpression reduces hungtingtin aggregation and cellular toxicity, while reduced CRMP1 results in increased aggregation and toxicity.
Some of the PCBs are not broken down in this way, and their continued stimulation of AHR2 disrupts cellular functions, leading to toxicity.
Chung and Khurana used the wealth of data from the yeast alpha - synuclein toxicity model to clue them in on key cellular processes that became perturbed as patient neurons aged in the dish.
«In both models, we found that neither IBs nor kinase activity were the direct causes of cellular toxicity leading to neuronal death,» said Dr. Skibinski, who was the paper's lead author.
«Correct protein folding is critically important, which is why we are focusing on the diverse set of complex cellular mechanisms, including molecular chaperones, that promote efficient folding and prevent toxicity,» says Dr. Adrian Israelson, who heads the Cellular and Molecular Neurodegeneration Lab in the BGU Department of Physiology and Cell Biology.