Sentences with phrase «in chimeric»

Attempts to test the intrinsic role of S1pr1 using BM chimeras were unsuccessful due to difficulties in achieving efficient reconstitution of IL7RαhiCcr6 + cells and our finding that many of the cells developing in the chimeric mice appeared activated based on CD69 expression (not shown).

Balb / c third - party allografts were acutely rejected in chimeric animals, as were control MRL allografts in non-chimeric animals.

Allogenic allografts in chimeric mice were harvested on either day 40 or day 100 - post transplantation.

Third - party Balb / c cardiac allografts were transplanted in chimeric MRL mice to test for specificity.

However, when challenged to differentiate immediately after purification, each exhibits strong lineage bias, with the endoderm marker - expressing fraction unexpectedly able to contribute to the extra-embryonic endoderm in chimeric embryos.

Fialuridine induces acute liver failure in chimeric TK - NOG mice: A model for detecting hepatic drug toxicity prior to human testing.

Some worry that such human cells, when combined with animal embryos, could develop into brain cells, sperm, or egg cells in the chimeric offspring.

Not exact matches

Kite Pharma, one of the companies chasing a new generation of cancer drugs called chimeric antigen receptor T - cell (CAR - T) therapies, announced a patient death in a clinical trial of its experimental KTE - C19.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

In December 2016, the New England Journal of Medicine published a study demonstrating that a chimeric antigen receptor therapy (CAR - T) caused glioblastoma regression.

JCAR015 is a CD19 - directed chimeric antigen receptor technology (CAR - T) product candidate that has been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.

And third, somebody has to recognize that the kids are in fact chimeric twins.

Chimeric Ig - peptide was presented 100 to 1000 times more efficiently than free synthetic peptide and was able to prime virus - specific T cells in vivo.

Whether the armamentarium of alternative vaccine candidates presently in the pipeline (including inactivated, live attenuated, chimeric, recombinant, subunit and DNA vaccines) will improve efficacy beyond 56 % remains to be established.

Those proteins, called chimeric antigen receptors, recognize the cancer cells in the patient's body.

Fifteen years ago, Campana helped develop the chimeric antigen receptor that's used in Kymriah today.

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

Hybrid, or chimeric, animals may eventually grow human organs to be used in transplants.

«This chimeric role of employment / education affords us several concessions, including deferring student loans, increased time off... plus sick and holiday leave, decent benefits, the ability to pay into the UC retirement plan, and the flexibility of participating in lectures, seminar, conferences, and classes.»

In a 2009 study, University of Georgia at Athens cloning expert Steve Stice created 29 chimeric piglets by injecting pluripotent stem cells into pig embryos before implanting them into a surrogate womb.

The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.

A stem cell biologist known for work cloning mice, he says he was brought onto the team to produce the chimeric mice described in the paper.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Extracts from the brains of FFI patients transmitted disease to transgenic mice expressing a chimeric human - mouse PrP gene about 200 days after inoculation and induced formation of the 19 - kilodalton PrPSc fragment, whereas extracts from the brains of familial and sporadic Creutzfeldt - Jakob disease patients produced the 21 - kilodalton PrPSc fragment in these mice.

«NYGC is thrilled to have this work be our first published example of the explosive power of collaborations between deeply invested biologists like those in the Simon lab including Elana Simon, and thoughtful bioinformatics scientists like Nicolas Robine and NYGC team, who worked together so effectively with the tools of genomic sequencing and analysis to discover this new chimeric protein and cancer target,» says Robert Darnell, head of Rockefeller's Laboratory of Molecular Neuro - Oncology, HHMI investigator, and president and scientific director of NYGC.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

«We discovered chimeric RNAs in the tumor samples — made when DNA deletions create unnatural products that can drive cancer,» says Nicolas Robine, co-first author and NYGC Computational Biologist.

The team developed a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 — the same fragments to which PV - causing antibodies and their B cells typically bind, as Payne's laboratory and others have shown in prior studies.

This is a schematic of how a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

Biologist Stuart Newman of the New York Medical College in Valhalla is trying to get a patent on a «humanzee» — a chimeric animal made from human and chimpanzee embryos.

In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal modeIn their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal modein an animal model.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

The work stems from an earlier collaboration between Potash and David J. Volsky (also from Columbia University); they established a chimeric HIV clone with a genetic modification that allows the virus to propagate in rodents instead of humans.

In the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patientIn the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patientin 70 % of ovarian cancer patients.

Chimeric antigen receptor - modified T cells in chronic lymphoid leukemia.

Chimeric Antigen Receptor - T Cell Therapy: Practical Considerations for Implementation in Europe

Richard Vague, the event's honorary chair, took the podium to acknowledge the vast achievements of the ACC, as did Lori Alf, a multiple myeloma patient of Edward Stadtmauer, MD, chief of Hematologic Malignancies, whose cancer is in remission after receiving chimeric antigen receptor (CAR) therapy.

Chimeric mice generated from cells reprogrammed for pluripotency (induced pluripotent stem cells, or iPS cells) show significant health problems, pointing to further challenges that must be overcome before such cells can be used in the clinic, noted iPS researcher Shinya Yamanaka said on Saturday (June 14).

We have introduced chimeric genes which express GFP in a variety of organelles within the plant cell in order to study the dynamics of cell organization.

The UK patents relate to the CRISPR - Cas9 gene editing systems involving single - guide RNA in both non-cellular and cellular settings (UK Patent No. 2518764) and chimeric CRISPR - Cas9 systems in which the Cas9 protein is modified to provide alternative DNA - modulating activities (UK Patent No. 2537000).

To do so, the engineered ESCs would be injected into developing mouse embryos, the embryos allowed to develop into chimeric mice (with a fraction of the cells in the adult mice derived from the engineered ESCs), and chimeric adults mated to produce completely transgenic offspring.

In CAR T therapy, a person's own T cells — disease - fighting immune cells — are removed and sent to a lab where they are genetically re-engineered to produce chimeric antigen receptors (CARs) on their surface.

Mechanisms of Response and Resistance to CD19 - targeting Chimeric Antigen Receptors in Leukemia J. Joseph Melenhorst, PhD, University of Pennsylvania, United States

He is the Principal Investigator of international Phase - II, randomized trial of Chimeric 14.18 or Temsirolimus in combination with Irinotecan / Temozolomide through Children's Oncology Group (COG).

Expression Level of a Chimeric Kinase Governs Entry into Sporulation in Bacillus subtilis.

Diagram of the complete synthetic signal transduction system in transgenic plants, using TNT as the ligand, signaling through the bacterial chimeric histidine kinase, and adapted response regulator, then activating a transcriptional response.

In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].

«This shows that our chimeric mouse model is medically relevant and can be used to validate novel drugs in a pre-clinical setting,» says Bissig.

Anaplastic lymphoma kinase (ALK)-- positive anaplastic large cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric nucleophosmin - ALK.

There has even been work on chimeric chickens in Scotland, Australia, and California.