Sentences with phrase «in cholesterol biosynthesis»

A key enzyme in cholesterol biosynthesis is 3 - hydroxy -3-methylglutaryl — CoA reductase (the target for statins), which is activated by insulin, which means that an increase in blood glucose and consequently of insulin levels will lead to increased endogenous cholesterol synthesis.

WHAT TO AVOID TO HELP PREVENT ALZHEIMER»S DISEASE • STATIN DRUGS: Cholesterol is a vital part of the myelin sheath insulating neurons and assisting in propagation of nerve impulses; metabolites in the cholesterol biosynthesis pathway inhibited by statins are required to produce CoQ10 as well as functional GLUT4s.

Similarly, other genes involved together with DHCR7 in the cholesterol biosynthesis pathway, are also associated with a number of genetic disorders / syndromes (e.g., Antley - Bixler syndrome — POR gene), presenting with several common prenatal clinical manifestations (Porter & Herman, 2011).

HMG - CoA (3 - hydroxy -3-methylglutaryl — coenzyme A) reductase (HMGR) catalyzes the committed step in cholesterol biosynthesis.

Not exact matches

He earned his Ph.D. in biochemistry in 1981, studying cholesterol biosynthesis in the laboratory of James Gaylor.

Sucrose - induced vacuolation results in increased expression of cholesterol biosynthesis and lysosomal genes.

The authors wrote: «We argue that in the era of precision medicine, potential differences in response to compounds that disrupt the cholesterol biosynthesis pathway must be respected, especially as their effect may be defined by both genetic makeup and life events at the same time.»

Eight controlled clinical trials have shown that statin drugs cause Coenzyme Q10 depletion by inhibition of HMG - CoA reductase, which is the rate limiting step in cholesterol and Coenzyme Q - 10 biosynthesis.

The extract contains nine different monacolins that inhibit cholesterol biosynthesis in liver cells.

The pathway that results in the formation of 3 - hydroxy -3-methylglutaryl — CoA from acetyl CoA also occurs in the cytosol of hepatic cells where it is used instead for the biosynthesis of cholesterol.

Because of this they do not take part in the biosynthesis and transportation of cholesterol.