He joined the Gladstone Institutes as a postdoctoral fellow in 1993 where his early research into proteins
involved in cholesterol metabolism led him to the study of embryonic stem cells and differentiation.
The research stated that there is mounting evidence which suggests that a defect
in cholesterol metabolism in the brain may play an important role in Alzheimer's Disease.
Moore's lab researches the mechanisms that underlie imbalances in metabolism as it relates to atherosclerosis and obesity, including noncoding RNA's regulating
role in cholesterol metabolism and inflammation.
The main mechanisms of action of phytochemicals are: antioxidant activities, modulation of detoxification enzymes, decreasing of platelet aggregation,
alterations in cholesterol metabolism, control of concentrations of steroid hormones and endocrine metabolism, reduction of blood pressure, and antibacterial and antiviral activities.
I am not really all that concerned because my PhD is
in Cholesterol Metabolism and I have no other risk factors (except maybe a bit too much stress!)
Liu et al. (45) demonstrated that the hepatic effects of WBV were correlated with reductions in sterol regulatory element binding protein 1c (SREBP1c), a transcription factor that regulates genes involved
in cholesterol metabolism (50).
The importance of APOE (a gene involved
in cholesterol metabolism) has long been recognized in AD.