Sentences with phrase «in chromosome segregation»
Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis).
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Cheeseman and his laboratory have focused on three key groups or complexes of proteins that play essential roles in chromosome segregation in human cells.
The Kops group studies the processes involved in chromosome segregation during cell division, with a focus on molecular mechanisms, evolution and chromosomal instability.
We further aim to understand origins and causes for evolutionary diversity in chromosome segregation protein networks, using various model organisms including Tetrahymena thermophila and Toxoplasma gondii.
We wish to understand which mutations underlie this disease and how these mutations cause errors in chromosome segregation.
The resulting data suggests that PP2ACdc55 plays a pivotal role in chromosome segregation, although we are still a way from knowing how the processes go wrong.
The altered movement of the microtubules apparently contributes to errors in chromosome segregation, and so represents a new explanation for age - related infertility,» stated CRCHUM researcher and Université de Montréal professor Greg FitzHarris.
Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.
Aneuploidy is a manifestation of a Chromosomal Instability (CIN) phenotype: the tendency of a cell to make frequent errors in chromosome segregation.
Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.
Filamentous polymers called microtubules play vital roles in chromosome segregation and molecular transport.