Sentences with phrase «in circulating cell»

Dr. Vasmatzis» research on the «Quantification of Somatic Chromosomal Rearrangements in Circulating Cell - free DNA From Ovarian Cancers» is published in the July 20 edition of Scientific Reports.

Not exact matches

closed off to one another, the porous memory foam used in the Ultimate Gel Memory Foam mattress is of an open cell configuration — meaning that air can more freely circulate and heat is not trapped as easily.

While memory foam is often dense and has tightly packed cells of air that are... MORE closed off to one another, the porous memory foam used in the Ultimate Gel Memory Foam mattress is of an open cell configuration — meaning that air can more freely circulate and heat is not trapped as easily.

Most of the cells are neutrophils, a type of phagocyte that normally circulates in the bloodstream.

When these cells break down after birth, they produce a yellow pigment called bilirubin, which circulates in the blood.

In the human body, occasional cell death translates into degradation and release of their DNA, which then circulates in the blood, before being eliminateIn the human body, occasional cell death translates into degradation and release of their DNA, which then circulates in the blood, before being eliminatein the blood, before being eliminated.

We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

This suggests that the presence of AR - V7 in circulating tumour cells does not preclude response to galeterone as has been shown to be the case for abiraterone and enzalutamide.»

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

Much of the research on CD8 + T cells has focused on studying them in the circulating blood, which has a dominant phenotype of CD8αβ +.

The other two major targets in the field, circulating tumor cells and exosomes, come with their own challenges.

«There was this initial thought that [circulating tumor cells] are only present at late stage,» says Sollier - Christen, but she notes that in the past year, several studies using more sensitive techniques have found such cells much earlier in tumor development, even before the tumor becomes visible by conventional imaging techniques.

Thanks to the computer programs created by the researchers, they can control each cell individually in various ways, or create virtual communication between several cells, which circulate messages in an easily reconfigurable order.»

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

«Circulating tumor cells have the advantage that they are... intact living cells,» says Michael Kazinski, senior director and head of global product management for sample technologies at Qiagen in Hilden, Germany.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

This was first noticed in humans many years ago when cells containing the male «Y» chromosome were found circulating in the blood of women after pregnancy.

These results were facilitated by the permanent cultivation of circulating tumour cells of patients with advanced SCLC in Vienna.

In this new study, scientists observed that microchimeric cells are not only found circulating in the blood, they are also embedded in the braiIn this new study, scientists observed that microchimeric cells are not only found circulating in the blood, they are also embedded in the braiin the blood, they are also embedded in the braiin the brain.

The engineered cells will circulate and, the team hopes, home in on the cancer, says Lu.

The creations had stored well at refrigerated temperatures and circulated in the body with survival time on par with that of original red cells.

The study team wanted to understand the particular traits of the tumor cells circulating in the blood and in the sites where the cancer has spread.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Called nonstructural protein 1 (NS1), it is the only one of the 10 viral proteins secreted by infected cells to circulate freely in the bloodstream.

A dense layer of cells called the blood - brain barrier protects the organ from germs circulating in the body, and from the immune cells that combat them.

Malaria parasites, which are transmitted through the bite of an infected mosquito, cause the most destruction during the part of their life cycle when they dwell in red blood cells circulating through the body.

In addition we have added Dr. Topol's March 2012 research paper published in Science Translational Medicine, «Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction.&raquIn addition we have added Dr. Topol's March 2012 research paper published in Science Translational Medicine, «Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction.&raquin Science Translational Medicine, «Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction.&raquin Acute Myocardial Infarction.»

Maternal immune cells are inevitably circulating through the fetus, and in mouse studies, these cells rebelled against the donor cells.

Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.

Stem cell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging heacell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging heaCell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging hearts.

The findings were published online today in the journal Immunity in a paper entitled, «Human circulating PD - 1 + CXCR3 - CXCR5 + memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses.»

Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments.

Early in their study, the team noticed differences between the expected 3BNC117 abundance in humans over time, given its half - life, and the actual abundance, a discrepancy hinting that some of the antibodies may be targeting not just circulating virus particles but HIV - infected cells as well.

«Our hypothesis was that Lyme bacteria shed vesicle - like particles — or fragments — derived from the cell wall of the bacteria circulating in the serum of individuals.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

They gave DON and an altered derivative, dubbed 5c, intravenously to two monkeys and, 30 minutes later, measured the amount of the drugs in the monkeys» cerebrospinal fluid and circulating plasma, which is the liquid portion of blood that remains after blood cells, platelets and other cellular components are removed.

A new study in the journal Science claims that our planet's air circulates as four major cells, not two as is the conventional wisdom.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

Moreover, a substantial increase in circulating endothelial progenitor cells, which repair damaged blood vessels, was noted after consuming bread made from the ancient grain Verna.

«Despite the identification of circulating tumor cells (CTCs) and cell - free DNA (cfDNA) as biomarkers capable of providing clinically relevant information in cancer patients, at present their identification is not routinely used in clinical practice,» explains Silvia Morbelli, MD, PhD, of the IRCCS San Martino — IST National Cancer Research Institute and University of Genoa in Genoa, Italy.

T lymphocytes, immune cells which circulate in the blood, must migrate across the walls of blood vessels in order to reach inflamed tissue.

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory responsIn particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory responsin circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the bodyIn a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the bodyin the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the bodyin the bloodstream correlates with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the bodyin the body).

In addition, while cfDNA correlated with tumor metabolism, no association was found with circulating tumor cells (CTCs).

A more abundant and less invasive source of tumor DNA may be cell free tumor DNA found circulating in the blood.

The rapid drop in circulating T cells during sleep «show [s] that even one night without sleep affects the adaptive immune system,» says first author Luciana Besedovsky.

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.