Sentences with phrase «in clonal»

Prostate cancer cells in clonal cultures exhibit distinct clonal morphologies.

Their subsequent work (3) in clonal cultures revealed three distinct types of clones with profoundly different proliferative capacity.

Interestingly, long - term — cultured human epithelial cancer cells in clonal cultures also form holoclones, meroclones, and paraclones, and tumor cell holoclones have been hypothesized to harbor stem - like cells or cancer stem cells.

However, tissue culture is impeded by the occurrence of somaclonal variation, resulting in clonal abnormality.

Cooperation and competition in heterogeneous environments: the evolution of resource sharing in clonal plants.

The Cancer, Ageing and Somatic Mutation Programme seeks to provide leadership in data aggregation and informatics innovation, developing high - throughput cellular models of cancer for genome - wide functional screens and drug testing, and exploring basic scientific questions about the role somatic mutation plays in clonal evolution, ageing and development.

Postdoctoral researcher in Genomics / Computational Biology The available postdoctoral position concerns developing and applying novel genomic and computational approaches to study non-genetic heterogeneity in clonal population of Read more about Postdoctoral position in RNA Genomics & Computational Biology -LSB-...]

A new study from the German Cancer Research Center has revealed that the entire species of Marmorkrebs originate from a single mother crayfish, in a clonal reproduction that may help shed new light on processes in tumor development.

The key finding, he said, «illustrates how unisexual reproduction introduces limited genetic diversity in clonal populations already well adapted to an environment, which may drive outbreaks of drug resistant pathogenic microbes.»

«Stochastic variations of migration speed between cells in clonal populations.»

«Our observation that groups matched their compositions to the one optimal at their site of origin (regardless of their current habitat) is particularly important,» Pruitt and Goodnight write, «given that many respected researchers have argued that group selection can not lead to group adaptation except in clonal groups and that group selection theory is inefficient and bankrupt.»

Specimens of that species may be up to 100,000 years of age, e.g., see the 2012 article «Portuguese scientists discover world's oldest living organism» at theportugalnews.com/news/view/1152-20 or see the February 2012 paper, «Implications of Extreme Life Span in Clonal Organisms: Millenary Clones in Meadows of the Threatened Seagrass Posidonia oceanica» on which the news article was based, which is available online at the PLOS ONE website at plosone.org/article/info:doi/10.1371/journal.pone.0030454.

Not exact matches

In California there is a colony of Palmer's Oak trees called Jurupa Oak that has been alive 13,000 years through clonal reproduction.

Pando, aka «The Trembling Giant», is a clonal colony of a single male quaking aspen (Populus tremuloides) in the Fishlake National Forest in Utah in the U.S..

This marriage of distinct soil type, clonal selection, elevation and microclimate produces outstanding fruit uniquely expressive of its growing region in our Burgundian style Chardonnays and Pinot Noirs.

There were the obvious differences between the wines arising from clonal selection (most were made from the ubiquitous Gingin or Mendoza clone of chardonnay, which first arrived in WA in the early»70s, but a couple were made from more recently imported French clones), vintage variation and sub-regional influence (wines from the cooler south of Margaret River tended to be leaner and crisper than those from the warmer north).

Sonoma County Barrel Auction lots range in size from five to 20 cases and include unique single vineyard bottlings, specific clonal selections, blends, wines aged using special barrel regimes and joint lot wines made by collaborating wineries.

In this new study published in Nature Communications, Mariaceleste Aragona, Sophie Dekoninck and colleagues define the clonal dynamics and the molecular mechanisms that lead to tissue repair in the skin epidermiIn this new study published in Nature Communications, Mariaceleste Aragona, Sophie Dekoninck and colleagues define the clonal dynamics and the molecular mechanisms that lead to tissue repair in the skin epidermiin Nature Communications, Mariaceleste Aragona, Sophie Dekoninck and colleagues define the clonal dynamics and the molecular mechanisms that lead to tissue repair in the skin epidermiin the skin epidermis.

All worldwide Mycobacterium leprae strains analyzed so far, more than 400 in total, have been found to have essentially identical genomes, or be clonal.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

«A Wild Weedy Scourge,» page 24 «Resource Heterogeneity, Soil Fertility and Species Diversity: Effects of Clonal Species on Plant Communities,» by J. Alexander Eilts and colleagues in May issue of The American Naturalist describes how plants like cogon grass, which spread through expansive underground networks, reduce biodiversity even in soils that are thought to boost it.

Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

Dr Ignacio Vazquez - Garcia, the first author from the Wellcome Trust Sanger Institute and University of Cambridge, said: «We found that the degree of diversity within the cell population — known as clonal heterogeneity — played a major role in the acquisition of antimicrobial resistance.

To answer this question, the researchers used the clonal plant Potentilla reptans in an experimental setup that simulated different light - competition settings.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

We found that this process of clonal selection — the basis of cancer formation in the body — is also routinely happening in laboratories.»

DFTD is an asexually reproducing clonal cell line, which during the last 16 years has been exposed to negative effects as infected devils, approximately 33 % of the population, have been removed from one site, the Forestier Peninsula, in Tasmania between 2006 and 2010.

«Another model is punctuated evolution in which CNAs are acquired in short bursts of crisis, followed by stable clonal expansion that form the tumor mass.

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

«Our finding of the horizontal transmission of a clonal clam leukemia extends the phenomenon to the marine environment, and demonstrates that this mechanism is more widespread in nature than previously supposed.»

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites.

In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell trials [56], [57In contrast, the safety record of hematopoietic stem cell gene therapy is less clear, with a significant frequency of gene - therapy induced oncogenesis or clonal outgrowth reported in several hematopoietic stem cell trials [56], [57in several hematopoietic stem cell trials [56], [57].

The article Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization was published in the journal Nature Communications on September 6, 2016.

It is significant that parallel immunization of llamas 8 and 9 gave rise to two separate clonal lineages of CD4 binding site broadly neutralizing HCAbs which have both incurred a three residue deletion in CDR2 during maturation.

Roswell Park Comprehensive Cancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

B21, B9 and A14 belong to two distinct clonal families as compared with the previously described anti — HIV - 1 VHH [26], [31], [36], [37] and 3E3 (Figure S3 in S1 Text).

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

To confirm karyotype stability, we examined four of the clonal lines, each of which had been expanded from one single cell to a confluent line in a 10 - cm dish over a period of approximately one month (Figure 7).

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes.

Later, this edited clonal cell line can be differentiated into a cell type relevant to the disease under study (e.g., neurons, as depicted in Figure 1).

When plated as single cells in wells of a 96 - well plate, at least 50 % of those seeded cells will proliferate into clonal colonies.

Traditionally, establishing clonal populations from edited hiPS cells grown and passaged as colonies is inefficient and time consuming; often, it results in cell death or premature differentiation.

This workshop explored mathematical tools and problems in describing the life cycle, stage conversion, and clonal expansion of T. gondii by bringing together expertise in parasitic diseases, epidemiology, population genetics, disease modeling, network dynamics, evolutionary dynamics, and nonlinear analysis.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

Single - cell seeding of edited hiPS cells in this system results in high survival of pluripotent, edited clones, yielding a diverse set of edited clonal lines.

However, only one lineage (type II) is widespread and predominates in the global populations, a phenomenon known as clonal expansion.

Pluripotency was maintained in all edited clonal lines, as evidenced by the persistent expression of the three pluripotency markers.