Sentences with phrase «in cohorts of patients»

She has been involved in the identification of early biomarkers of placental damage in cohorts of patients at high risk of pregnancy complications, with specific focus on the role of autoimmunity and of vascular inflammation.

The company is partnering up with a group of clinicians at Stanford, as well as telemedicine vendor American Well, to test whether Apple Watch's heart rate sensor can detect abnormal heart rhythms in a cohort of patients, according to two people familiar.

In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.

The team then validated these findings in a cohort of patients with type 2 diabetes.

Additional potential novel biomarkers will also be evaluated and reported in this cohort of patients.

You found it by looking for rare germline variants in a cohort of patients with a specific form of cancer.

Tanguy Seiwert, M.D., of The University of Chicago, presented results of a phase 1b trial of Merck's pembrolizumab in a cohort of patients with advanced head and neck cancer.

Conti V, Leone MC, Casato M, Nicoli M, Granata G, Carlesimo M. High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease.

Not exact matches

Indeed a paper published earlier this year in the Journal of Perinatology analyzed homebirths attended by a certified nurse midwife (CNM) and found that they had double the risk of neonatal death of CNM attended hospital births, even though the hospital birth cohort included high risk patients.

In the first study evaluating patient - reported cosmetic outcomes in a population - based cohort of older women with breast cancer, The University of Texas MD Anderson Cancer Center researchers found that less radiation was associated with improved cosmetic satisfaction long - terIn the first study evaluating patient - reported cosmetic outcomes in a population - based cohort of older women with breast cancer, The University of Texas MD Anderson Cancer Center researchers found that less radiation was associated with improved cosmetic satisfaction long - terin a population - based cohort of older women with breast cancer, The University of Texas MD Anderson Cancer Center researchers found that less radiation was associated with improved cosmetic satisfaction long - term.

CDI's platform is especially helpful in constructing panels for biomarker discovery, because researchers can begin by using patient samples or banked samples to compare immune profiles of cohorts that show particular symptoms (or no symptoms in the case of control samples).

Seventeen patients had undergone treatment before Gelsinger, who was in the final cohort — the one receiving the highest dose of the therapy.

While further study of larger patient groups with longer follow - up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.»

Khachaturian says a proper test of Roses» findings — using Roses» methods in a larger cohort of patients — has not yet been done.

Co-author Subrata Sen, Ph.D., also a professor of Molecular Translational Pathology, notes, «These findings are a significant advance considering that there's nothing else available now to detect early stage pancreatic cancer that has gone through blinded validations in multiple patient cohorts.»

Patients were defined as having a prolonged hospital stay, if they fell in the 75th percentile of the study cohort in terms of stay duration.

Overall toxicity levels were similar across groups only for acute side effects (i.e., those that occur closely following treatment), with eight percent of patients in each cohort reporting acute grade 3 + side effects.

They are based on a retrospective cohort study of 7,431,858 patients in the University HealthSystem Consortium database, which contains information from contributing academic medical centers in the United States and affiliated hospitals.

«Our new study indicates that a differential therapeutic approach can be beneficial for older patients in melanoma and suggests that age should be taken into account to design better treatments for certain cohorts of patients.»

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

Within the test cohort, all patients with MS had central veins in more than 45 per cent of brain lesions, while the rest had central veins visible in less than 45 per cent of lesions.

Researchers conducted a retrospective cohort study of patients admitted to the ICU at Barnes - Jewish Hospital in St. Louis, Missouri from 2005 through 2012.

Medical historian Flurin Condrau of the University of Zurich in Switzerland, who is not involved in the project, says the notes are a great resource for historians, with a dream cohort of tens of thousands of patients over nearly 4 decades.

One of the toughest tasks is replicating these studies — an especially difficult proposition in diseases that are not overwhelmingly heritable, such as asthma, or ones that affect fairly small patient cohorts, such as certain childhood cancers.

A phase II basket study is ongoing to determine whether these early results can be confirmed in a much larger cohort of patients.

The Chronic Hepatitis Cohort Study is an analysis of records from a large, geographically and racially diverse group of 9,783 patients receiving care at four large U.S. health systems: Henry Ford Health System in Detroit; Kaiser Permanente Northwest in Portland, Oregon; Kaiser Permanente in Honolulu and Geisinger Health System in Danville, Pennsylvania.

In this study, researchers analyzed prostate tissue biopsies from two cohorts of prostate cancer patients.

In Cohort A, pembrolizumab shrunk tumors by more than 30 percent in eight of 170 patients, or five percent, and stabilized the disease in 35, or 21 percent, of those previously treated for mTNBIn Cohort A, pembrolizumab shrunk tumors by more than 30 percent in eight of 170 patients, or five percent, and stabilized the disease in 35, or 21 percent, of those previously treated for mTNBin eight of 170 patients, or five percent, and stabilized the disease in 35, or 21 percent, of those previously treated for mTNBin 35, or 21 percent, of those previously treated for mTNBC.

After a 15 - month follow up, 16 patients from two cohorts had partial responses, with an overall response rate of 38 and 27 percent in each of the two cohorts.

The trial investigated the drug in two separate cohorts of patients: Cohort A, which included 170 patients with heavily pretreated metastatic triple negative breast cancer (mTNBC) regardless of PD - L1 expression, and Cohort B, which included 52 patients with PD - L1 - positive tumors who received it as first - line therapy.

The remaining patients in this cohort had a lower chance of survival.

In Cohort B — those who received pembrolizumab as first - line therapy — 12 of 52 patients, or 23 percent, saw tumors shrink by more than 30 percent, while the disease was stabilized in nine of them, or 17 percenIn Cohort B — those who received pembrolizumab as first - line therapy — 12 of 52 patients, or 23 percent, saw tumors shrink by more than 30 percent, while the disease was stabilized in nine of them, or 17 percenin nine of them, or 17 percent.

In cohort two, which had patients that were heavily pretreated, six patients had a partial response, and six achieved stable disease for at least six months, for a combined disease control rate of 54.5 percent.

The researchers analyzed microarray data of samples from German patients and from an IPF cohort of the Lung Tissue Research Consortium in the U.S.

By evaluating the molecular changes that occur in large cohorts of ovarian cancer patients, the researchers were able to identify several lncRNAs that are linked to the disease.

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subseIn a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein the HR positive subset but not in the HR negative subsein the HR negative subset.

In the second cohort of 77 COPD patients, the 23 patients with allergic sensitization (determined by immunoglobulin E testing) were significantly more likely to wheeze, to experience nighttime awakening due to cough, and to have COPD exacerbations requiring antibiotic treatment or an acute visit to the doctor.

«Accordingly, we examined the effects of allergic disease on respiratory health in two sets of patients with COPD, one a nationally representative sample of 1,381 COPD patients from the National Health and Nutrition Survey III (NHANES III) and the other a cohort of 77 former smokers with COPD from a study of the effects of endotoxin exposure on health status.»

The second cohort of 140 patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double - blind arm of the study in the next six months.

We got permission to continue following the patients in this study and we also recruited a second cohort of patients to try to run a series of placebo controlled studies.

Dr. Zhang points out that the unique value of this study derives from the ability to perform longitudinal assessments of cognition in PD patients over a long time period and access to data from a large cohort that began when patients were in the earliest stage of disease.

«The findings need to be confirmed using targeted RNA sequencing, or internal validation, and then tested in a new cohort of patients, or external validation.

Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

Researchers expect the data presented in this study to fuel the formation of large national and international research consortiums to conduct comprehensive, systematic analysis of inherited (germline) genome data in large cohorts of uveal melanoma patients.

An earlier analysis of diets in the same patient cohort by Fuchs and his colleagues found a significant link between coffee consumption and reduced recurrence and mortality in colon cancer.

The earlier discovery of mutations in UBQLN2 gene, which causes ALS and ALS / dementia in children and adults, in the Siddique lab led to the screening of the UBQLN family of genes in a large cohort of patients with familial ALS, resulting in the identification of the UBQLN4 mutation.

The study results of 50 patients from this cohort are now described in the New England Journal of Medicine.

«The cohort study has found that the sofosbuvir / daclatasvir combination is associated with a high rate of SVR4 in difficult - to - treat patients infected by genotype - 1 hepatitis C.

The results were confirmed in a genome - wide association study and replicated in 1,745 patients in four independent cohorts of patients with IBS and control subjects.