Sentences with phrase «in cutaneous»

My own story begins as a dermatologist on this traditional route — Northwestern Medical School then University of California for a residency in cutaneous medicine (that's skin).

Another study found it accelerated healing and decreased inflammation in cutaneous (skin) wounds.

Interferon - alpha Resistance in a Cutaneous T - Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression

Manfe V, Biskup E, Rosbjerg A, Kamstrup M, Skov AG, Lerche CM, Lauenborg BT, Odum N and Gniadecki R. miR - 122 regulates p53 / Akt signalling and the chemotherapy - induced apoptosis in cutaneous T - cell lymphoma.

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

Human skin microbiome RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum — Stephanie Walter — Scientific Reports

Our results clearly indicate that the expression of DDX3 is decreased in HCC and the subcellular localization of DDX3 is altered in cutaneous SCC (see Figs. 5 and 6).

A, immunohistochemical staining of DDX3 in cutaneous SCC and paired normal skin.

As in cutaneous melanoma, mucosal melanomas harboring BRAF V600 mutations may respond well to combined BRAF and MEK inhibition.

[61,62] Small retrospective studies of biochemotherapy (cisplatin, vinblastine, dacarbazine, interferon alfa - 2b, and IL - 2) also demonstrated activity that was similar in cutaneous and mucosal melanomas.

This observation indicates that the loss of DDX3 nuclear localization is a frequent event in cutaneous SCC.

With nivolumab monotherapy, the observed objective response rate was 23.3 % in the mucosal melanoma group compared with 40.9 % in the cutaneous melanoma group.

Additionally, an extensive loss of its nuclear localization was observed in cutaneous squamous cell carcinoma (SCC) compared with normal squamous cells.

Project Title: Topical Resiquimod Can Induce Disease Regression and Enhance T - cell Effector Functions in Cutaneous T - cell Lymphoma

[38,41] While gene amplifications are rare in cutaneous melanoma, they are present in approximately 85 % of mucosal melanomas.

Much as in cutaneous melanoma, the role of PD - L1 status as an immune biomarker in mucosal melanoma remains unclear.

DDX3 was strongly immunolocalized in the nucleus and less intensively in the cytosol of squamous cells in normal skin, but the nuclear staining was lost or dramatically decreased in cutaneous SCC.

Topical Resiquimod Can Induce Disease Regression and Enhance T - cell Effector Functions in Cutaneous T - cell Lymphoma

It is known that one of the pathways involved in cutaneous cancer is mediated through CDKN2A which is a gene associated with melanoma dysregulation through its pro-oncogenic products p16INK4a (Cyclin - Dependent Kinase Inhibitor P16) and p14ARF (P14 alternate open reading frame)[28].

p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma.

MicroRNA - 34a directly targets high - mobility group box 1 and inhibits the cancer cell proliferation, migration and invasion in cutaneous squamous cell carcinoma.

Jak3, STAT3, and STAT5 inhibit expression of miR - 22, a novel tumor suppressor microRNA, in cutaneous T - Cell lymphoma.

TTD hemizygotes (XpdTTD / KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD / TTD mice [21].

Angiotropism is a marker of extravascular migration of melanoma cells along vascular and other structures and a prognostic factor in cutaneous melanoma.

One application is the prognosis of the melanoma: the authors show in tumor biopsies that the amount of RAB7 in a cutaneous tumor defines the risk of developing metastasis.

Not exact matches

The case - control study, published online in of the Journal of the American Academy of Dermatology, used a large clinical database of electronic medical records to collect detailed data of cutaneous melanomas developing in 462 women aged 49 years or younger.

«Pregnancy - associated melanoma is associated with higher death rates: Study sought to investigate histopathology, staging, risk factors, and outcomes of cutaneous melanoma in women younger than 50.»

Polydefkis, also director of the Cutaneous Nerve Lab at the Johns Hopkins Bayview Medical Center, says that patients with transthyretin amyloidosis typically have traditional symptoms of nerve damage, known as neuropathy, such as numbness or burning in the feet.

Starting in three weeks, he and his colleagues will collect cutaneous bacteria from mountain yellow - legged frogs in the isolated Dusy basin area of the Sierras: «We'll go in with skin swabs, take samples, culture bacteria, grow it in the lab at San Francisco State, then wait a week, go back out and inoculate a bunch of frogs,» Vredenburg says.

In the field results of a study by Brianna Lam, a graduate student in the J.M.U. Department of Biology, published in the journal Biological Conservation in 2009 (as well results published by Vredenburg and Harris in 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuIn the field results of a study by Brianna Lam, a graduate student in the J.M.U. Department of Biology, published in the journal Biological Conservation in 2009 (as well results published by Vredenburg and Harris in 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin the J.M.U. Department of Biology, published in the journal Biological Conservation in 2009 (as well results published by Vredenburg and Harris in 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin the journal Biological Conservation in 2009 (as well results published by Vredenburg and Harris in 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin 2009 (as well results published by Vredenburg and Harris in 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin 2008 in Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin Abstracts of the General Meeting of the American Society for Microbiology), revealed that wild mountain yellow - legged frog populations in the Sierras differed greatly in their amount of cutaneous J. lividuin the Sierras differed greatly in their amount of cutaneous J. lividuin their amount of cutaneous J. lividum.

But long before Leishman's discovery in an Indian morgue, others had described the lesions of Old and New World cutaneous leishmaniasis.

Whereas animal studies have suggested that both cutaneous and proprioceptive percepts can be evoked using this approach, the perceptual quality of the stimuli can not be measured in these experiments.

Research teams focused on both cutaneous and uveal melanoma are fast - tracking discoveries into the clinical setting, and bringing novel therapeutic options to patients in the Philadelphia region,» said Karen Knudsen, Director of the Sidney Kimmel Cancer Center.

A research team at The University of Texas at El Paso is one step closer to developing an effective human vaccine for cutaneous leishmaniasis, a tropical disease found in Texas and Oklahoma, and affecting some U.S. troops stationed in Afghanistan and Iraq.

The Penn team, in collaboration with Alain Rook, MD, director of the Cutaneous T - cell Lymphoma Program and a professor of Dermatology, aims to develop a molecular taxonomy for mutations in SS patients.

«In principle, one could save people suffering from cutaneous late - stage anthrax infections and maybe treat a variety of other similar diseases,» said Bier.

«We found that Asian and black patients have a substantially higher risk of severe cutaneous adverse reactions to urate - lowering drugs than do white or Hispanic patients, which correlates with the frequency of the HLA - B * 5801 gene in their U.S. populations,» says Hyon K. Choi, MD, DrPH, of the MGH Division of Rheumatology, Allergy and Immunology, senior author of the report that has been published online in Seminars in Arthritis and Rheumatism.

In addition to monitoring the response of injected melanoma tumors, we are also measuring the boost in the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology PrograIn addition to monitoring the response of injected melanoma tumors, we are also measuring the boost in the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Prograin the anti-tumor immune cells of patients after injection,» explained Amod A. Sarnaik, M.D., assistant member of Moffitt's Cutaneous Oncology Program.

«Despite the concerns, the development of BRAF inhibitors is a major milestone in treating patients with BRAF - mutant melanoma,» concluded study co-author Vernon K. Sondak, M.D., chair of the Cutaneous Oncology Program at Moffitt.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

The authors note that their definition of a mustache includes any «visible presence of hair on the upper cutaneous lip and included both stand alone moustaches (for example, Copstash Standard, Pencil, Handlebar, Dali, Supermario) as well as moustaches in combination with other facial hair (for example, Van Dyke, Balbo, The Zappa [or even the Santa].

UPV / EHU researchers have developed a method for the diagnosis and prognosis of cutaneous melanoma, the type of skin cancer with the highest mortality rate.This method will help not only in the more effective early detection of this cancer, but also in the development of more personalized treatments.

In the trial, co-led by Rachael Clark, MD, PhD, associate professor of Dermatology at Harvard Medical School, Alain Rook, MD, professor of Dermatology and director of the Cutaneous Lymphoma Program at Penn Medicine, and Joel M. Gelfand, MD, MSCE, associate professor of Dermatology and medical director of the Clinical Studies Unit at Penn Medicine, twelve patients who had previously undergone an average of six treatments for early stage CTCL were treated with topical resiquimod gel at varying doses and intervals.

In the new work, Amel Meddeb - Garnaoui and Wafa Kammoun - Rebai, of the Institut Pasteur de Tunis, and colleagues studied the immune responses against P. papatasi salivary gland extract (SGE) of 790 people living in areas of Tunisia endemic for cutaneous leishmaniasiIn the new work, Amel Meddeb - Garnaoui and Wafa Kammoun - Rebai, of the Institut Pasteur de Tunis, and colleagues studied the immune responses against P. papatasi salivary gland extract (SGE) of 790 people living in areas of Tunisia endemic for cutaneous leishmaniasiin areas of Tunisia endemic for cutaneous leishmaniasis.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Findings from the study conducted at the MGH Cutaneous Biology Research Center and Center for Molecular Therapeutics have been published in the open - access journal PLOS ONE.

Sima Sharara, from the University of North Carolina, Chapel Hill, USA, and Souha Kanj, from the American University of Beirut Medical Center, Lebanon, briefly describe the devastating effects of the conflict on the Syrian healthcare system and focus on the increasing number of cases of poliomyelitis, measles, and cutaneous leishmaniasis in the region, which they say is nothing short of a regional, and arguably global, public health emergency.

Cutaneous leishmaniasis, a disfiguring parasitic disease transmitted by infected sand flies, has been present in Syria for decades, but cases there have increased dramatically in recent years, and the epidemic has spread to neighboring countries.

Risk of cutaneous malignant melanoma in patients with «classic» atypical - mole syndrome: a case - control study.

We conducted bioinformatic analyses of 703 transcriptomes to probe the immune landscape of primary cutaneous melanomas in a population - ascertained cohort.