Sentences with phrase «in cytochromes»

But in 2013, a research scientist in El - Naggar's laboratory, Sahand Pirbadian, discovered that these projections, referred to as «nanowires,» were actually extensions of the cell membrane covered in cytochromes — proteins containing iron that facilitate electron transport.

Malaria parasites can develop mutations in the cytochrome b gene that make them resistant to a drug called atovaquone, an ingredient in the antimalarial medication Malarone.

The second phase (Phase II) of detoxification occurs in the cytochrome P - 450 enzyme system in the membranes of the endoplasmic reticulum, resulting in conjugation.

One factor that is true for cats, is that they are notoriously deficient in the Cytochrome p450 liver metabolism pathway.

Not exact matches

biochemical evidence such as Cytochrome - cyto - C is just one of the thousands of sequences and is not proof of common ancestry, as there are more variations than similarities in the genetic code, on the other hand a study of the amino acid make - up reveals that man is closer to lamprey than are fish.

The same evidence was found in another family of proteins, the cytochromes c, and this made it possible to conclude that the common ancestor of yeast, plants, and vertebrates lived about 1.2 billion years ago.

Each cell in our body «breathes» due to the work of only the cytochrome - c oxidase, others we have not.

From a genetic screen, we found that the cytochrome P450 oxygenase CYP - 13A12 acts in response to the EGL - 9 — HIF - 1 pathway to facilitate the O2 - ON response.

They found 46 mutations in just one gene, the cytochrome b gene, in nine voles taken from the 30 - kilometre restricted zone around Chernobyl.

Two haplotypes (genetic variants) of the Cytochrome Oxidase Type I sequence were detected: the «World haplotype» found in France, New Caledonia, French Polynesia, Singapore, Puerto Rico and Florida; and the «Australian haplotype» found in Australia.

Resistance involves a cytochrome P450 enzyme CYP9K1 which for the first time a role in pyrethroid resistance is established.

The enzyme is a member of the cytochrome P450 family of enzymes, which are involved in the formation and breakdown of various molecules and chemicals.

Expression of a liver protein (Cytochrome P450 26A1) that regulates levels of retinoic acid — a by - product of vitamin A — was higher in the sufficient group.

Clopidogrel is metabolized in the liver, where it is turned into its active form via a group of enzymes called cytochrome P450, or CYP for short.

Interestingly, many birds that are not red still have cytochrome P450 genes — to make red pigments in the retina that enhance their color vision.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

This work led to Inz - 5, which exhibited dramatically improved potency and selectivity for fungal cytochrome B. Although cytochrome B is highly conserved across humans and many pathogenic fungi, including Cryptococcus neoformans, Aspergillus fumigatus, and Rhizopus oryzae, Inz - 5 exploits important differences in the amino acid sequence of the protein that enable selectivity for fungi.

Because the compound is metabolized too rapidly for study in mice, the team mimicked its effects by knocking out cytochrome B in C. albicans and infecting mice with this mutant strain.

Called cytochrome P450 2A5, the enzyme is known to increase in people with liver ailments.

University of Illinois professor of entomology May Berenbaum, who led the study, said that many organisms use a group of enzymes called cytochrome P450 monooxygenases to break down foreign substances such as pesticides and compounds naturally found in plants, known as phytochemicals.

Instead, the cytochrome mutation developed in the new colony in a matter of weeks.

«Our goal is to define the role of these cytochromes in the metabolic switching between different terminal electron acceptors,» said Dr. Thomas Squier, a PNNL biochemist and senior author of the publication.

Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune - Deficient Mice.

Zuzana Kronekova (Roedel, TUD)-- «Assembly of mitochondrial ubiquinol - cytochrome c oxireductase complex in yeast Saccharomyces cerevisiae: The role of Cbp3p and Cbp4p assembly factors» (2005)

A New Fluorescent Probe for Protein Interactions More Proof of Outer Membrane Cytochrome Role in Electron Transfer Scientists Show How Bacteria Move Electrons Across a Membrane

«Targeted Protein Degradation of Outer Membrane Decaheme Cytochrome MtrC Metal Reductase in Shewanella oneidensis MR - 1 Measured Using Biarsenical Probe CrAsH - EDT2.»

Gaspare Benenati (Kurzchalia, MPG)-- «Osmotic balance and establishment of polarity in the C.elegans embryo require cytochrome P450 CYP31A» (2006)

Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy.

One of these SNPs resulted in a premature stop codon within Sevir.7 G140700 (+1860 from the transcriptional start site; Figure 3B), which encodes the syntenic ortholog of Dwarf11 (D11) in rice, the cytochrome P450 724B involved in BR biosynthesis (Tanabe et al., 2005; Sakamoto et al., 2006).

We report the molecular identity and characterization of the Bristleless1 (Bsl1) locus in S. viridis, which encodes an inflorescence - expressed paralog of the Cytochrome P450 724B1 (CYP724B1) enzyme required for BR biosynthesis.

Two distinct clades of cytochrome P450 genes redundantly perform C - 22 hydroxylation, the rate - limiting step in BR biosynthesis (Fujita et al., 2006; Sakamoto et al., 2006).

Regulation of transcript levels of the Arabidopsis cytochrome p450 genes involved in brassinosteroid biosynthesis

Chronic treatment with azide in situ leads to an irreversible loss of cytochrome c oxidase activity via holoenzyme dissociation.

These results mark another step toward understanding the cellular mechanisms that enable a bacterial protein - in this case, the cytochrome MtrC - to transfer electrons to minerals in soil, sediment, and subsurface materials.

The symposium will focus on the roles of the major enzymes participating in metabolism of xenobiotics including carcinogens and drugs — the membrane monooxygenase systems containing cytochromes P450 — and highlight the key advances in their mechanisms of action at the molecular level.

In response to this report, SENS Foundation CSO Dr. Aubrey de Grey has said that «If this is as good as it looks, I think it could be a real game - changer», and Dr. O'Connor and his team at the SENS Foundation RC are considering testing a construct based on Teitell's methods in a system that the RC has already generated and used for testing of allotopic expression of cytochrome In response to this report, SENS Foundation CSO Dr. Aubrey de Grey has said that «If this is as good as it looks, I think it could be a real game - changer», and Dr. O'Connor and his team at the SENS Foundation RC are considering testing a construct based on Teitell's methods in a system that the RC has already generated and used for testing of allotopic expression of cytochrome in a system that the RC has already generated and used for testing of allotopic expression of cytochrome B.

In recent years, Michel and his research group mainly studied two types of oxygen reductases: the so - called superfamily of «heme - copper oxidases», and the «cytochrome bd oxidase».

A famous example from the superfamily is cytochrome c oxidase, the last enzyme in the respiratory electron transport chain located in the mitochondrial membrane (see graph).

Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo.

This protein is one of the nuclear - coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

Translation of cytochrome f is autoregulated through the 5 «untranslated region of petA mRNA in Chlamydomonas chloroplasts

Function of the Chlamydomonas reinhardtii petD 5 ′ untranslated region in regulating the accumulation of subunit IV of the cytochrome b6 / f complex

Post-transcriptional defects in tobacco chloroplast mutants lacking the cytochrome b6 / f complex

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational use of drugs, clinical pharmacology David J. Webb, UK - hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and drug utilisation

(1988) containing the papers presented at a meeting organized by the two of us and held in Rome and in the Convent of Santa Teresa (Caprarola) where the structure - function relationships and the physiopathology of cytochrome oxidase were discussed in depth.

Genetic polymorphisms in the gene encoding cytochrome P450 (CYP) 4F2, a vitamin K oxidase, affect stable warfarin dose requirements and time to therapeutic INR.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

A system of enzymes called cytochrome P450 (CYP), found in the liver, kidney, lungs and the brain do the job.