Sentences with phrase «in cytosol»

The pathway that results in the formation of 3 - hydroxy -3-methylglutaryl — CoA from acetyl CoA also occurs in the cytosol of hepatic cells where it is used instead for the biosynthesis of cholesterol.

Under non-stress conditions a transcription factor called NRF2 is sequestered in the cytosol by another protein called Keap1.

The result is an excess of acetyl - coA, which then follows various metabolic pathways, both in the mitochondria (Krebs Cycle) and in the cytosol, resulting in the production of ketones.

The goal of the MTs is to do their work in the cytosol and keep the toxic metals away from the mitochondria and nucleus of the cell.

Phase I takes place in the cytosol and involves oxidation, reduction and / or hydrolysis in an attempt to reduce the toxicity of the chemical.

Animals use two forms of this enzyme, one in the cytosol and one in mitochondria.

They tagged fluorescent molecules to curvature - sensing «BAR» proteins that are present in cytosol, and observed how they behaved.

DDX3 was strongly immunolocalized in the nucleus and less intensively in the cytosol of squamous cells in normal skin, but the nuclear staining was lost or dramatically decreased in cutaneous SCC.

These cells relied on a protein called cyclic GMP - AMP synthase (cGAS) to sense the viral DNA in the cytosol before the foreign DNA became integrated into the host genome.

Kriwacki also said that the paper was significant because it emphasizes the importance of the role that p53 plays in the cytosol of the cell, in addition to its role in the nucleus; his further studies are seeking to map that molecular machinery in great detail.

The same domain also acts as an attachment point for BCL - xL in the cytosol.

Also, through these studies we solidified the mechanistic understanding for how p53 functions in the cytosol, which complements its pro-apoptotic role in the nucleus.»

Furthermore, we examined the expression of KLF4 in brain metastatic tissues by immunohistochemistry and found that KLF4 was expressed more in the nucleus and significantly less in cytosol in brain metastatic tissues compared with primary tumors (Fig. 6C and D).

Alcohol - treated HCV / Sod2 + / - mice also showed a greater concentration of FOXO3 in the cytosol of the cell compared to the nuclear location found in other types of mice.

The non-invasive force measurement method based on the fluctuation theorem enabled measurement by analyzing the fluctuating behavior of cargo vesicles in the cytosol subject to thermal noise and so on.

The recent development of genetically - encoded fluorescent biosensors specific to glutathione (GSH), the most abundant cellular redox buffer, has facilitated the IGB research group's discovery of distinct alterations of glutathione redox potentials in the cytosol versus mitochondria within the cell.

Time lapse images collected on a Zeiss Axiovert 200M fluorescence microscope in the core imaging facility of IGB allowed real - time monitoring of the redox state in the cytosol and mitochondria of live cells.

It had been thought that misfolded proteins spontaneously clump together in the cytosol, the fluid component of a cell's interior.

For proteins in the cytosol, the liquid inside the cell, these random molecular processes include differences in the break - down of proteins, or random partitioning into the two cells that form during cell division.

In order to visualize this signal, the scientists performed experiments with transgenic Arabidopsis plants which were genetically modified to express a protein in the cytosol, the liquid inside the cells, which breaks down and releases light energy after it has bound calcium ions.

«Using this elegant method, we can reveal that not all the incoming viral DNA enters the cell nucleus as originally expected, but a significant fraction remains in the cytosol, the fluids of the cytoplasm,» explains Greber.

Sofar, studies have focused on how the RQC recognizes and clears blocked ribosomes in the cytosol.

The synthesis of these proteins in the cytosol is tightly coupled totheir import into the mitochondria.

Bacteria (colorized in blue) are located either in the cytosol or within a membrane - bound vacuole.

The mitochondria are located in the cytosol of the cells, outside of the cell nucleus; the cell's DNA genome is located inside the nuclear membrane.

Not exact matches

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

Against a background of nematode worms, this graphic depicts the stressed mitochondria (lower right, blue and red) accumulating lipid droplets (red balls) in the interior or cytosol of the cell.

The researchers were surprised to find that knockdown of one specific mitochondrial chaperone, mtHSP70, elicited a unique stress response mediated by fat accumulation, resulting in improved protein folding in the interior or cytosol of the cell.

LLO lacking the PEST - like sequence accumulated in the host - cell cytosol, suggesting that this sequence targets LLO for degradation.

Their preliminary findings indicate that MUS81 - induced movement of DNA to the cytosol also occurs in human cancer cells, including prostate cancer, breast cancer, colorectal cancer, uterine cancer, leukemia, and melanoma cells.

With this in vivo model, the research team uncovered evidence of distinct organellar perturbations in redox balance following inhibition of GSH synthesis with buthionine sulfoximine, demonstrating increased mitochondrial oxidation in response to GSH depletion compared to the cytosol.

Taken together, these findings indicate different redox requirements for the glutathione thiol / disulfide redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

In guarding the cell against genetic damage, the p53 machinery functions both in the nucleus of the cell and in the cell's gel - like cytosoIn guarding the cell against genetic damage, the p53 machinery functions both in the nucleus of the cell and in the cell's gel - like cytosoin the nucleus of the cell and in the cell's gel - like cytosoin the cell's gel - like cytosol.

Bits of misfolded proteins processed by specialty organelles may accumulate in the main compartment of the cell, the cytosol, where they can be tagged for disposal by the cellular garbage service.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

Mahley added that he was surprised to see that ApoE had left the secretory pathway; his research had found that only fragments of ApoE entered the cytosol (he had not detected these fragments in the nucleus).

TB bacteria can evade capture by phagolysomes, getting free in the cell's cytosol where a backup mechanism, autophagy, seeks again to deliver them to lysosomes.

To further clarify the role of Prx - dependent mitochondrial signaling, we expressed different forms of dPrx5, which unlike the uniquely mitochondrial dPrx3 is found in multiple subcellular compartments, including mitochondrion, nucleus and cytosol.

ApoE4 treatment induced in addition apoptosis through translocation of Death - domain associated protein - 6 (Daxx) from the nucleus to the cytosol, suggesting an activation of the Ask - 1 pathway.

For proteins that do not fold correctly in the ER and retrotranslocate back to the cytosol, Rapoport's group is working on a comprehensive picture of the ERAD pathway in yeast.

Then non-selective macroautophagy of the cytosol leads to accumulation of Pho8Δ60 in the vacuole, where it is cleaved to generate an active enzyme.

Pho8Δ60 localizes to the cytosol in an inactive form unless autophagy is induced.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

Acetyl - L - carnitine assists in maintaining cellular energy metabolism by facilitating the transport of fatty acids from the cytosol into the mitochondria.

Life Extension Acetyl - L - Carnitine Arginate assists in maintaining cellular energy metabolism and transport of fatty acids from the cytosol into the mitochondria within the cell.

The mitochondria is involved in the couple first steps of cortisol production and spits it out into the cytosol and then finishes the process assuming everything's working properly.