Sentences with phrase «in cytostatic»

Pharmacy technician, 2014, 2016, Oncology Hospital, Bialystok, Podlaskie, Poland, Assistence for Registered Pharmacist in cytostatic drug preparation.

Not exact matches

Fluorine is also found in many agrochemicals, and about 20 - 30 % of modern pharmaceuticals, ranging from antimalarial and cytostatic drugs to inhalation anesthetics, blood substitutes, and liquid ventilation agents.

Blocking Wingless / beta - catenin also inhibits the MGMT enzyme, which in turn prevents cytostatic resistance.

Flavopiridol should exert cytostatic activity because of the pivotal role of the cdks in the cell division cycle.

Evidence demonstrating its cytostatic activity includes the finding that it inhibits the growth of a broad spectrum of human tumor cell lines in vitro.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

At low cytostatic concentrations, ActD causes ribosomal stress, which decreases MDM2 activity, resulting in p53 stabilization and activation.

Further, at a low cytostatic concentration (2 nM), ActD causes ribosomal stress leading to a decrease in HDM2 activity and thereby p53 stabilization and activation.

A low, non-genotoxic, dose (about 1 nM) of ActD has been shown to induce a reversible cytostatic effect in normal proliferating dermal fibroblasts and protect them from the aneuploidy induced by the aurora kinase inhibitor VX - 680 and the toxic effects of gemcitabine [46, 47].

ActD has been shown to have a reversible cytostatic effect and the ability to arrest cells in both the G1 and G2 phase of the cell cycle [17].