In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results
in decreased numbers and reduced functions of MDSCs.
In a recent survey conducted by the Design and Technology Association, 705 of 1,300 respondents said that government accountability measures were resulting
in decreasing numbers of pupils opting to study the subject at GCSE.
Indeed, a 705 of 1,300 respondents to a survey conducted by the Design and Technology Association, said that government accountability measures were resulting
in decreasing numbers of pupils opting to study the subject at GCSE and, in some schools, it has been cut entirely.
Second, even if reforms succeed
in decreasing the number of suspensions, do they also succeed in reducing disproportionate suspension rates by race and disability?
Women — who make up more than half the teaching workforce in middle and high schools — hold fewer than 15 % of all undergraduate engineering degrees [iv] and are choosing STEM majors and careers
in decreasing numbers [v].
We also want to be leaders
in decreasing the numbers of unwanted pets.
By working with animal shelters across the United States, Brian plays an instrumental role
in decreasing the number of pets euthanized.
The shelter's work is definitely seeing results
in decreasing the number of animals that come in.
Based on our participation in numerous national coalitions focused on animal / shelter overpopulation issues; our work in shelter medicine, shelter research and as a major animal welfare grant maker; and our 100 + years as a direct service provider in New York City as well as our more recent direct participation in intensive, collaborative efforts with more than 10 ASPCA partner communities across the United States, the ASPCA has determined that a number of indicators should be tracked to understand progress
in decreasing the number of animals at risk.
These efforts, despite damaging the shark population, were shown to be ineffective
in decreasing the number of interactions between humans and tiger sharks.
* blocking, deflecting or disturbing wildlife, resulting
in decreased numbers of wildlife in the area
Better training and the constant reinforcement of safety standards would go a long way
in decreasing the number of caught - in - between construction accidents.
India has made significant progress
in decreasing the number of cases of malaria and the number of deaths caused by the disease (although the official numbers of rural Indians dying from malaria remains underestimated).
Not exact matches
However U.S. commanders say the precision weapons used by the air force have meant an overall
decrease in the
number of civilian casualties from combat operations as fewer people have been killed
in ground fighting.
Canada - wide, 67 % said property sales to foreign buyers increased
in the last year (a
number that's largely diminished because of a
decrease in foreign buying
in Calgary).
Therefore, while the
number of American workers
in the metals industry could increase by an estimated 33,464 jobs, the
decrease in other industries would be more significant: an estimated 179,334 jobs.
We believe that rising costs - which may have increased up to 18 percent
in some countries - will lead to a
decrease in the
number of international adoptions.
When attempting to lose weight, many people cut out meals
in the hope that it will
decrease the
number of calories they take
in.
Besides, with popularity of Facebook Live and Instagram Live, the
number and quality of offerings
in the market will only increase, even as the price
decreases.
The
number of smartphones reported stolen has
decreased in the last year, particularly
in major cities like New York, San Francisco, and London.
A year ago, the agency offered early retirement to a
number of employees and the
decrease in headcount achieved then was enough to mitigate the requisite budget cuts, Mills told reporters
in a meeting
in New York last week.
In this city, the
number of listings
decreased by 2.3 percent from 2016.
As consumers become more comfortable with shopping online, there will be continued
decreases in the
number of people who abandon their cart.
Although the
number of homes on the market increased this year, the average multi-million listing price
decreased slightly from $ 1.7 million
in 2016.
A
number of other embarrassing debacles followed — including reports that Uber had used a software tool to try to deceive authorities by «hiding» rides — and ultimately resulted
in a more than 20 %
decrease to the once high - flying company's valuation, from around $ 70 billion to an estimated $ 54 billion.»
«We have implemented
in the last two years a strong turnaround plan
in France, with strong
decrease of the employee
numbers in France and the close of five out of seven sites,» Combes told CNBC.
In the five years to 2000 — 01, the number of small businesses in Australia's state and territory capital cities increased by 6.4 per cent to 945,320, and only Hobart recorded a decrease in the number of small businesse
In the five years to 2000 — 01, the
number of small businesses
in Australia's state and territory capital cities increased by 6.4 per cent to 945,320, and only Hobart recorded a decrease in the number of small businesse
in Australia's state and territory capital cities increased by 6.4 per cent to 945,320, and only Hobart recorded a
decrease in the number of small businesse
in the
number of small businesses.
The
number who believe that life
in the U.S. is better than life
in Mexico has fluctuated over the years, but as of last year was measured at 48 %, a slight
decrease from 51 % seven years earlier.
The policy that councillors will vote on won't immediately
decrease the city's
number of payday loan businesses to 15 to match its
number of wards because it will grandfather
in existing companies, but will prevent new ones from opening, said Tom Cooper, the director of the Hamilton Roundtable for Poverty Reduction.
Employment
in this category
decreased between 2008 and 2010, but fortunately the
number of job seekers and job openings is expected to be even into 2020.
This came after slight
decreases in the December
numbers.
More than one million people die from AIDS each year — an enormous
number, but one that has
decreased steadily throughout the past decade thanks
in large part to anti-retroviral medicines that can slow its spread within the body.
«Insurance and retail companies were
decreasing their hires
in large
numbers and that brought the overall
number down,» said NACE research manager Andrea Koncz.
In the second quarter, the
number of closed transactions
decreased more than 50 percent year - over-year.
The dollar figure represents a whopping 57 % increase over Q1 2013, while the deal
number is nearly 4 % higher (12 % increase
in dollars and 14 %
decrease in deals from Q4 2013).
The downsizing is largely due to a
decrease in the
number of shares sold by stockholders.
Additionally, the
number of closed transactions reported
in the first quarter
decreased by 36 percent as compared to the same time period
in 2008.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth
in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures
in European countries that may increase the amount of discount required on Gilead's products; an increase
in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift
in payer mix to more highly discounted payer segments and geographic regions and
decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations
in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations
in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the
number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials
in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations
in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates
in the timelines currently anticipated; Gilead's ability to receive regulatory approvals
in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta
in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes
in its stock price, corporate or other market conditions; fluctuations
in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time
in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
Except as expressly provided
in the Plan, no Participant shall have any rights by reason of any subdivision or consolidation of shares of stock of any class, the payment of any dividend, any increase or
decrease in the
number of shares of stock of any class or any dissolution, liquidation, merger or consolidation of Alphabet or any other corporation.
By offering strong evidence of mini flash crashes increasing transaction costs through widening the desired execution price between a market's buyers and sellers, while at the same time
decreasing the
number of opportunities to buy and sell
in a market, Golub et al. [21] corroborated and quantified the intuition that mini flash crashes do indeed harm market liquidity.
Rogers followed with 9.6 percent and only 437 complaints, which is a dramatic 65 percent
decrease in the
number of complaints over the same period last year.
In the 1990s, a number of studies reviewed deregulation's impact on airline wages, attributing decreases in the range of 10 to 20 percent for pilots, and more for flight attendant
In the 1990s, a
number of studies reviewed deregulation's impact on airline wages, attributing
decreases in the range of 10 to 20 percent for pilots, and more for flight attendant
in the range of 10 to 20 percent for pilots, and more for flight attendants.
For example, while a
number of communities are debating how to provide benefits to gig economy workers, without policies that ensure a baseline wage threshold or that grant workers a voice
in determining their wages and benefits, low - road companies could respond to requirements to contribute to benefits with commensurate
decreases in pay.
That's not all, either; the group is working with other brands to
decrease the
number of calories consumed from beverages
in the marketplace by 20 % by 2025 (here is a great resource for that initiative).
Nevertheless, that percentage
decrease in number of accidents remains impressive, especially considering that Tesla's autopilot system only uses basic algorithms alongside a limited suite of sensors.
Again, latest figures from the Office of the Chief Actuary show that the
number of Canadians who contributed to their RRSP has
decreased from 29 per cent
in 2000 to 24 per cent
in 2010.
Moving on to the latest employment report, released Friday, that showed a slight
decrease in the unemployment rate widely attributed to a drop
in the
number of individuals looking for work, Gundlach said it was a bleed - off of the temporary increase
in employment due to unseasonably warm weather.
Low values like 0.3 and 0.5 tell us that the query has been
decreasing in searches throughout time, and high
numbers like 1.5 indicate us the opposite.
While many areas of the United States of seen
decreases in the
number of new businesses created each year, St. Louis has grown and thrived with business creation growing 18 % from 2012 to 2013 alone!
In a tax policy speech Wednesday in Missouri, Trump singled out Kelly's work to decrease the number of illegal border crossings when he was secretary of homeland securit
In a tax policy speech Wednesday
in Missouri, Trump singled out Kelly's work to decrease the number of illegal border crossings when he was secretary of homeland securit
in Missouri, Trump singled out Kelly's work to
decrease the
number of illegal border crossings when he was secretary of homeland security.