Sentences with phrase «in defense against infection»

Not exact matches

The discoveries reported in two independent studies in the American Journal of Human Genetics on January 7 add to evidence for an important role for interspecies relations in human evolution and specifically in the evolution of the innate immune system, which serves as the body's first line of defense against infection.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

But if an accident leads to substantial blood loss, for instance, or the defense against a pathogen requires more blood cells in the course of an infection, the stem cells are activated.

An appropriate amount of inflammation in the body is beneficial for defense against bacterial infection, but uncontrolled inflammation leads to inflammatory diseases.

«Key mechanism in the plant defense against fungal infections.»

This is particularly true within the human body, where iron is concealed in cells and large iron - binding proteins as a first line of defense against infection.

Looking for an answer, Emerman and colleagues homed in on the immune protein TRIM5α, one of several proteins involved in innate immunity, the body's first line of defense against viral infection.

In a review published June 1 in Trends in Immunology, researchers discuss how the omentum is also an important immune organ that serves as a first line of defense against toxins and infection — hardly what you'd expect from a layer of faIn a review published June 1 in Trends in Immunology, researchers discuss how the omentum is also an important immune organ that serves as a first line of defense against toxins and infection — hardly what you'd expect from a layer of fain Trends in Immunology, researchers discuss how the omentum is also an important immune organ that serves as a first line of defense against toxins and infection — hardly what you'd expect from a layer of fain Immunology, researchers discuss how the omentum is also an important immune organ that serves as a first line of defense against toxins and infection — hardly what you'd expect from a layer of fat.

Knowing the answer is important both as a matter of basic immunology and because NK cells, as crucial members of the body's first line of infection defense, are often the subjects of efforts to harness the immune system in protection against infections and cancer.

To verify the importance of HIF - 1alpha in the defense against UPEC infection, the researchers studied mice with reduced HIF - 1alpha levels.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

In people with SCID, the stem cells that would become T cells — one of the immune system's main lines of defense against infection — lack a crucial protein receptor that tells them to start reproducing.

This resulted in a staggering 50,000 virus - host protein interactions, approximately 500 of which appeared to be involved in viral infection.By removing the interacting host proteins from the cell one at a time, the researchers were able to determine what their functional contribution was in the infection process: whether the host proteins were hijacked by the virus and used to spread infection, or whether they were part of a defense mechanism against the virus.

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.

He is a member of the National Academy of Sciences and the Institute of Medicine, and is the recipient of the 2009 Robert Koch Award, from the Robert Koch Foundation, in recognition of his groundbreaking research work into the mechanisms of defense against bacterial infection.

IL17 is known to play a role in host defense against cutaneous Candida albicans and Staphyloccus aureus infection (Cho et al., 2010; Conti and Gaffen, 2015) and to be induced in rats by Y. pestis (Comer et al., 2010).

Macrophages embedded in the GALT are part of the innate immune system, or the non-specific, first line of defense against infection (Fasano, 2011; Yu & Yang, 2009).

Supports strong kidney health, aids in detoxification pathways and the antioxidant defense system, helps defend against infection and supports immune health * --

If - G is a potent antimicrobial cytokine that is the first line of defense in the blood stream against infection.

There is some feeling that nasal vaccines may provide a more complete stimulation to the area of the immune system responsible for defense against the infection in question.

From this perspective, social adversity and perceived threat in childhood should upregulate the innate immune system, a system that provides immediate defense against infection, and enhance pro-inflammatory response tendencies as a way to prepare for potential impending tissue damage and infection.