Sentences with phrase «in different cell»

To confirm the finding, normal bone marrow cells were exposed to either IMGN632 or X-ADC for 72 hours at a concentration highly active against AML cells (100 pM), and the degree of caspase 3 activation, a marker of apoptosis, in different cell populations was assessed by flow cytometry (supplemental Figure 4).

An adaptable epigenetic machinery allows global epigenetic reprogramming to concur with local maintenance of critical epigenetic memory in the genome, and appears to regulate the tempo of global reprogramming in different cell lineages and species.

In the different cell types of the body, different protein producing genes are active or inactive, and many medical conditions also depend on altered activity of specific genes.

\ n \ n - Whether one needs the same cocktail of genes in every different cell type to get to the same stage of potency remains to be seen.

The overall score encompass several factors: reproducibility of the antibody staining in different cell lines (and if signal strength correlates with RNA expression levels); assays for enhanced antibody validation by using antibodies binding to different epitopes on the same target protein (independent antibodies), by knockdown / knockout of the target protein (genetic methods) and by matching of the signal with a GFP - tagged protein (recombinant expression); experimental evidence for location described in literature.

In the first step, stainings in different cell lines with the same antibody are reviewed and the results are compared with available protein / gene characterization data for subcellular location.

Understand the molecular mechanisms involved in different cell types and organisms to explain the differences in efficiencies

There has been a significant trend in biotechnology with companies investing in different cell therapy workflows.

All cells in the human body contain these bases in exactly the same order, but different genes are expressed in different cell types, allowing them to carry out their specialized functions.

Expression of Snail represses expression of E-cadherin and induces EMT in different cell types, including breast cancer cells [36, 37].

Transcription factors are expressed (or made) at different levels in different cell types, and control what genes are expressed in every cell, making sure, for example, that a liver cell remains a liver cell and does not become a neuron.

«We compiled a list of the proteins we thought Zika and similar viruses like dengue were using to get inside of cells, and then we looked to see which of these proteins were abundantly present in the different cell types of the developing brain,» said Pollen, who did the work with Tomasz Nowakowski, PhD, and a UCSF graduate student Carmen Sandoval - Espinosa, BS, both in Kriegstein's lab.

In recent years, research at Joslin and elsewhere has shown that insulin resistance may work differently in different cell types.

The results, although still preliminary in a quantitative sense, demonstrate that the reactivation of methylation - silenced genes does occur in different cell lines, suggesting it is a general phenomenon.

«In TSC, we know that in different cell types, the mutation causes different effects.»

The epigenome determines how instructions in the genome are carried out in different cell types.

This was extremely challenging, since many disparate functions have been attributed to Alix in different cell types.

«We want to know how this system works in all different cell types and in plants that we are interested in for biofuels.»

On the other hand, if the same mutation occurs in a different cell population located farther away from the SVZ, it will give rise to other subtypes,» said Chen.

Christian Seiser says: «Our results highlight that it is crucial to understand the individual role the various HDAC variants in different cell types and hence different types of cancer, before HDAC inhibitors can be used safely as therapeutics.»

The number of receptors for the neurotransmitter in the brain amounts to 14, occurring in different cell types.

She adds that it is also unclear why distinct patterns of these sites are observed in different cell types and under different drug treatments.

In the different cell types, the loops begin and end at different specific chromosomal locations, so each cell line's genome appears to have a unique population of loops.

In a paper published earlier this year in Molecular Cell, he and his team explored the activity of the FOS / JUN protein complex, which is expressed across many different cell types in the brain but appears to regulate unique programs in each different cell type.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

Those switches can be both near and far from the gene they regulate and act in different combinations in different cell types to give each cell type a unique genomic identity.

Understanding how a particular DNA sequence gives rise to a particular protein provides us with some insight into that protein, but a deeper investigation of how the protein is made, where it is located, and how much of it is present in different cell types is required to enable a true understanding of its function.

In order to isolate the 3D structure of the chromosome during metaphase, the authors used a combination of chromosome conformation capture technologies (3C, 5C and Hi - C) developed by the Dekker lab over the last decade to map the points of contact along the mitotic chromosome in different cell types synchronized to divide at the same time.

The results, which focus on two choices near the start of embryo formation, show that, when cells are making decisions about what to become, there is greater variation in the activity of the genes in different cells — the same genes may be turned on in some cells and off in others.

Kelley and his team also used mice with fluorescent markers in different cells of the ear followed by next generation sequencing.

HDAC3 functions on the epigenome, the molecular component of the cell nucleus that specifies which genes are expressed — and just as importantly, which ones are not — in different cells of the body.

Myriad control switches help to arbitrate how genes get expressed in different cells and tissues, and those switches are often triggered by maternal diet, toxic exposures and many other environmental factors.

Lue, whose essay described the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.

Allinase is found in different cells to alliin, cleanly separated by the cell walls, so the reaction occurs immediately after slicing the root with a knife.

Not exact matches

And most recently, United Airlines came under fire for forcibly removing a passenger from a flight when he refused to be involuntarily bumped — and you guessed it, the whole thing was caught, in several different angles, on cell phone cameras.

Mitchell has also equipped her house with power packs that can charge off her car engine, three cell phones from three different telecommunications carriers to make sure she can always be in touch with clients, and she has begun to offload things like her accounting and CRM functions to software as a service providers XERO and NetSuite respectively.

Instead, LaFlamme's research team in Toronto is taking a different approach through injecting a billion heart - muscle cells (otherwise known as cardiomyocytes) that have been developed from stem cells.

The goal here is to use «single - cell sequencing to understand how many different cell types there are in the human body, where they reside, and what they do,» as Nature reports.

In addition to the navigation tweaks, the updated app for both tablets and cell phones has a slightly different design, looking more like the new Google Maps desktop version.

Mr Musk said the carmaker had reduced the amount of cobalt in its Nickel - Cobalt - Aluminium battery cells produced by Panasonic below rival battery companies who use a different chemistry.Korean battery companies such as LG Chem and Samsung SDI, who produce Nickel - Manganese - Cobalt batteries, are expected to commercialise a lower - cobalt battery chemistry by next year.

In my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualIn my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin their ceremonies and rituals.

What is in contention is the «how» exactly we came from single - celled organisms, and there are many different theories on how that happened, but not IF that happened?

The average functional protein in a «simple» cell contains 200 amino acids (from the 20 different types).

Embryos are different from mere cell cultures in a number of important ways.

No, you say that microscopic human life is worthless in sperm and sacred when combined with a different type of cell a couple inches away.

Yes, it's just a clump of cells, they just grow in a different pattern than nail keratin.

If human brains are like body's cells, there is a natural point of specialization, in which new systems break away and form similar but slightly different branches, as cells in a body become fingers, feet, hands, etc..

This depends upon there being a brain, an arrangement of cells in a particular part of the body which by reason of its peculiar coordination makes the given routing able to «know» in a distinctively human manner — quite different from, although certainly continuous with, the sort of «knowing» that is possible for the higher grades of animal life.

Their brain is divided in regions with different coordinated functions, and it is composed of several hundred thousands of nerve cells (the honey bee has about 800,000).

Only a special systemic order of atoms in certain molecules of different types of brain cells, steady activity of these cells and excitations coming from sensoric nerves and running to associative and motoric centers are the basis of the peculiarity of brain function.