Sentences with phrase «in disease modeling»

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

Finally, the capacity of our platform for generating large amounts of disease - specific functional cholangiocytes will have broad applications for cholangiopathies, in disease modeling and for screening of therapeutic compounds.

Reported today in Disease Models & Mechanisms, Karim Si - Tayeb and colleagues in the research group of Bertrand Cariou from l'Institut du Thorax, Nantes used an innovative approach to develop unique patient cell - based models of PCSK9 - driven hypercholesterolemia.

«Our aim now is to study the role of these new gene switches in disease models.»

In normal mice, stem cells (pink) express dystrophin (green) and are able to easily generate new muscle fibers, but in the disease model, there is no dystrophin and the stem cells lose their sense of direction and have trouble generating new muscle fibers.

As next steps, the researchers would like to test their hydrogel matrix in animals with normal immune systems and in disease models.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

«We tried to untangle the large role aging appears to play in some of the most devastating neurological disorders,» said Edward Giniger, Ph.D., senior investigator at the NIH's National Institute of Neurological Disorders and Stroke and the senior author of the study published in Disease Models & Mechanisms.

Now, in an article published in Disease Models & Mechanisms, a team from the University of Alabama at Birmingham and Stanford University School of Medicine describe the use of a BDNF loop domain mimetic to improve motor function and object location memory in a mouse model of Rett syndrome.

This work, which is published in Disease Models and Mechanisms, could pave the way for early detection and treatment of hereditary copper metabolism disorders.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

New research published today in Disease Models & Mechanisms indicates that early intervention should be a key target in the development of new therapeutics for Friedreich's ataxia, as current treatments may be administered too late to target the disease effectively.

We're also mapping some of the components on that decision pathway and trying to figure out how to influence them one way or another and put them in disease models so we can see how we can effect a benefit.

«Many of these factors have previously appeared separately in disease models, but not all together in one model,» Pattanayak said.

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

B's ability to deliver potentially therapeutic genes in disease models.

Not exact matches

In order to value bitcoin and predict future prices, analysts at Barclays came up with a model that likens it to an infectious disease.

The role that big pharma plays in research, while valuable, is often tenuous, because profit models for many diseases are not always apparent, at least in the short term.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

We combine artificial intelligence with automation to conduct experimental biology at scale — testing thousands of compounds on hundreds of cellular disease models in parallel.

Kogan wrote in the email that he wanted to create statistical models that could accurately identify people at risk for various diseases and illnesses by examining their Web browsing and purchase behaviors, and combine that with medical data from Harvard.

[111] Cf. Jim D. Broadfoot, Richard C. Rosatte, and David T. O'Leary, «Raccoon and Skunk Population Models for Urban Disease Control Planning in Ontario, Canada,» Ecological Applications 11, no. 1 (2001).

«Future studies need to determine the health effects of these cocoas in models of human disease and to evaluate the consumer acceptability of the cocoas as part of a chocolate product.»

Comparing different policy scenarios to reduce the consumption of ultra-processed foods in UK: impact on cardiovascular disease mortality using a modelling approach

Graduated models are more common, since they are excellent in preventing and treating most circulatory diseases found in the limbs.

More broadly, updated longitudinal studies of the natural history of hypertension, diabetes, and cardiovascular disease are needed, because the data from the National Health and Nutrition Examination Survey that we used in our model are somewhat dated.

Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.

Of note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MIn addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and Min our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MI.

Potential confounding factors associated with diarrhoeal disease (p < 0.10) were included in a multivariate model where infant feeding was the main exposure.

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

The response in Newburgh was crafted in consultation with the U.S. Centers for Disease Control and Prevention and will serve as a national model for understanding PFOS exposure, state Department of Health spokesman James Plastiras said.

The SUV members talked in detail about treating violence as a disease and why their model program is successful.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot - Marie - Tooth disease type 2A

«I'm interested in bridging gaps between traditional epidemiology and mathematical modeling, hopefully developing improved methods for studying infectious diseases,» she says.

This is demonstrated in the studies reviewed in the special issue, which use computational models to examine brain processes, such as learning, emotion, dopamine signaling and information processing, and how processes interact in deficits underlying psychiatric disease.

«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»

Protein misfolding and aggregation had been identified as a major factor in mad cow disease, and research using yeasts as model organisms played a large role in those findings.

The researchers, including first author Matheus Victor, PhD, a postdoctoral research associate, set out to generate neurons that would mimic those of adult patients in order to model the onset and progression of Huntington's disease.

«It started to become quite evident to me that a research career in infectious disease epidemiology and mathematical modeling would be a fairly perfect combination of my longstanding interests in math and biology and medicine, as well as my emerging interest in infectious disease transmission and public health more generally,» she says.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

In an e-mail to Nature a few days later, Kogan said that zebrafish might be a useful model organism for psychiatric disease after all.

In the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generaIn the present study, the researchers have discovered a reason for reduced fertility in people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generain people with autoimmune polyendocrine syndrome type 1 (APS1), which increases the risk of developing autoimmune disease (caused by the immune system attacking and damaging healthy cells) and which is often used as a model for autoimmune disease in generain general.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Scientists for the first time have assembled a «disease in a dish» model that pinpoints how a defect in the blood - brain barrier can produce an incurable psychomotor disorder, Allan - Herndon - Dudley syndrome.

«I had been thinking about model organisms for a very long time in academia, and when I started to realize that there were all these people clamoring for their rare diseases I thought, «Why aren't people using model organisms to study them?