Understanding the biochemical processes that are important for maintaining these connections may help address the abnormalities in nerve cells that
occur in these disease states.
Using genetically engineered mice as disease models, my laboratory is interested in studying complement activation and
regulation in these disease states, thus eventually developing novel therapies.
Unlike that of epilepsy though, there is a lack of clinical data on the practical application of using the
diet in this disease state.
In particular, we are asking how molecules that are important in eye development both prevent and protect against damage
in disease states such as AMD and encourage regeneration of cells and their nerve fibers after injury.
To further explore the therapeutic potential of these receptors, Kalbe says his team are planning to obtain tissue from people with chronic airway diseases to compare them to healthy tissue, to observe if the receptors change in abundance or
function in disease states.
«Our research shows that some cells in Fuchs» dystrophy are still healthy, and that means that we could potentially stimulate them to divide and regenerate the
corneas in a diseased state,» said Dr. Jurkunas.
This will be an important approach for studying redox
changes in disease states including cancer, neurodegenerative disorders, cardiovascular disease, sickle cell disease and many others which are known to involve oxidative stress.»
Objective: To use innovative approaches of integrative biology to unravel how lymphocytes process an array of molecular signals arising from contact with dendritic cells, thereby better understanding the mechanisms that underlie immunity and how they are
altered in disease states.
Inflammation plays a central role in many disease states, and his goal is to understand the normal mechanisms by which pro-inflammatory signals protect against microbes and discern how they go
awry in disease states.
During pregnancy, periods of growth such as bodybuilding or recovery from tissue injury, or
in disease states where existing PUFAs undergo oxidative destruction, the requirement may increase.
Those who are
also in disease states sometimes choose to do a master cleanse in hopes it will speed up their recovery process or help to cure them from whatever ails them.
In other words, vaccines that are touted as being able to provide protection by keeping the
body in a diseased state of health.
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There is growing interest in the physiological role of DNL in normal biology and
in disease states such as obesity, Type 2 diabetes and cardiovascular disease.
In the disease state, the blood cells are sickle - shaped instead of round, leading to stabs of pain and eventual organ damage.
Today, Science strives to cover advances that reveal the specific ways in which the microbiota influences the physiology of the host, both in a healthy and
in a diseased state and how the microbiota may be manipulated, either at the organismal or molecular level, to improve the health of the host.
In a disease state, several mutations in TDP - 43 have been identified as a cause of some hereditary and sporadic ALS and FTD cases.
«
In the diseased state, this protein must change structurally to such an extent that the NAC region becomes accessible for other molecules, so that these regions can accumulate, start to grow and thus form the amyloid structures,» suspects the biophysicist Selenko.
«The challenge is to pick these individual gene variations and to really drill down and try and understand their function both in the normal operation of the immune system and
in the disease state.»
The ability to quantitatively compare structural and functional connectivity would be important to assess the relationship between these two measures of interregional connections in the healthy brain and
in diseased states.
Their lean muscle mass also has a standard deviation of about seven pounds, so an athletic healthy male could have about 14 pounds more lean mass than average, and a sickly man could weigh about 14 pounds less than average before he is considered to be
in a disease state.
Changes in these hormones can occur in natural physiological conditions,
in disease states, or as a consequence of drug administration.