Sentences with phrase «in diseases such»

Increased urine output precedes increased thirst in diseases such as kidney failure or diabetes.

TNR, another NK nightmare, will be responsible for an increase in diseases such as Rabies and a decrease in wildlife.

Some of these mutations are completely harmless, but others are thought to result in diseases such as cancer and even arthritis.

In diseases such as Crohn's and ulcerative colitis, the body's immune system attacks parts of the digestive tract.

«Our future goal is to characterize the distinct activities of monomer and dimer to see if we can «control» runaway inflammation and related neutrophil - induced tissue damage in diseases such as sepsis.»

The regulation of cell size and cell numbers is an important part of determining the size of organs in development, as well as of controlling cell over-proliferation in diseases such as cancer and diabetes.

My doctoral training, in the broad field of biochemistry, and cell and molecular biology, focused on mechanisms of glycosylation, which is altered in diseases such as cancer and neuromuscular dystrophy.

New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.

12/5/2007 Protein Found That May Provide Relief from Neuropathic Pain Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV / AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain - relieving drugs.

In a proof - of - principle study published in the journal Cell Stem Cell, the researchers report that defects in the regeneration of the myelin sheaths surrounding nerves, which are lost in diseases such as multiple sclerosis may be at least partially corrected following exposure of an old animal to the circulatory system of a young animal.

This accumulation in turn affects cell functions and can trigger neurodegeneration, like we see in diseases such as Alzheimer or Parkinson, both of which usually have a late onset.»

Inhibition of Bach1 itself has been suggested to be of benefit in diseases such as non-alcoholic steatohepatitis [50] and insulin resistance [51].

Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of Cambridge.

The collaborative work by Merck and Emulate researchers enabled new functionality for the Small Airway Lung - Chip to demonstrate the mechanism of action for therapeutic compounds acting on inflammatory disease states in the small airway, particularly in diseases such as asthma.

We study the maturation enzymes known as proprotein convertases, responsible for generating most secreted signaling proteins, and implicated in diseases such as diabetes, obesity, bone disease, and cancer.

Some of these proteins already have been implicated in diseases such as cancer, but only a minority were previously known to be «druggable.»

Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet / SciLifeLab and Gonçalo Castelo - Branco, Karolinska Institutet.

The gene Gas5Â acts as a brake on steroid hormone receptors, making it a key player in diseases such as hormone - sensitive prostate and breast cancer.

The relationship between force and cell deformation changes in diseases such as cancer, lung disease and heart disease, as well as muscle disorders.

This type of structural flexibility, called conformation entropy, is also a key feature in other peptides that form toxic plaques in diseases such as Huntington's disease, Type 2 diabetes, and Parkinson's disease.

(A) Bile ducts are blocked in diseases such as biliary atresia.

According to Gold, if the neurotransmitter fluctuation - based view does demote the dogma, there could be implications for researchers searching for drugs to counteract the effects of dementia that occur in diseases such as Alzheimer's.

It's helped Bertozzi capture the first images of glycoproteins, proteins coated with sugars that play a key role in diseases such as cancer.

The finding could help explain why eyesight degenerates with age — and in diseases such as macular degeneration and diabetes.

For example, the hippocampus is an area well - known for its involvement in memory and its dysfunction in diseases such as Alzheimer's, while the neocortex is involved in functions such as perception, consciousness, and language.

However, many of these regions are believed to play a role in diseases such as type 1 diabetes and Huntington's disease.

This balance can be disrupted in diseases such as Duchenne muscular dystrophy, which is caused by the lack of a muscle - specific protein, dystrophin.

«NGS technologies have vastly improved our understanding of the human genome and its variation in diseases such as cancer,» said Ken Chen, Ph.D., assistant professor of Bioinformatics and Computational Biology and co-author of the Nature Methods article.

Together with research into other immune - related genes in diseases such as Alzheimer's, the idea that immune processes are involved in some psychiatric phenotypes is looking ever more solid.

But in diseases such as breast cancer, the breakdown of this order has been associated with the rapid growth and spread of tumors.

Myelin, the fatty coating that protects neurons in the brain and spinal cord, is destroyed in diseases such as multiple sclerosis.

The musashi protein also has interesting implications for the development of drugs trying to prevent abnormal memory loss that occurs in diseases such as Alzheimer's.

The new research adds to the growing body of evidence of epigenetic changes in diseases such as rheumatoid arthritis, multiple sclerosis, type 2 diabetes, and obesity.

Poor air quality causes health problems worldwide and is a factor in diseases such as asthma, heart disease and lung cancer.

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

Non-adherence is common in diseases such as chronic obstructive pulmonary disease where only 33 % of patients continue their drugs after 10 weeks.

The maps also offer surprising insights into what goes wrong in diseases such as Alzheimer's and cancer.

An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been implicated in diseases such as Alzheimer's).

In diseases such as osteoporosis, the latter cells are too active and too much bone is degraded.

«It has profound implications for our understanding of human development and physiology, and gives us a remarkable wealth of resources to examine how disturbances of this system might result in diseases such as cancer.»

«We are working to find out how these circuits behave in anxiety disorders, so that we can hopefully learn to control fear in diseases such as PTSD,» says Li.

In some diseases such as Alzheimer's, however, decline is slow and inconsistent to begin with.

Scientists have noted that the blood - brain barrier is weakened in some diseases such as epilepsy or in cases of dementia, he says, but the stress findings are novel.

For unknown reasons our immune system attacks healthy cells, tissues and organs in a process called autoimmunity, which can result in diseases such as multiple sclerosis, type 1 diabetes, lupus or rheumatoid arthritis.

In diseases such as malaria and sickle cell disease, red blood cells break down, with harmful effects on the rest of the body — particularly the lining of small blood vessels.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Such pollution, as Business Insider's Lydia Ramsey explained in 2016, «is especially dangerous because it can get lodged in the lungs and cause long - term health problems like asthma and chronic lung disease.»

Throw in the complexities and heterogeneities of an evolving disease of genetic mutation, such as cancer, and the drug response from one person to the next can be even more variable.)

There are millions of people in the UK who suffer from work related diseases such as: