Sentences with phrase «in dyskeratosis»
This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand.
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«One of our killifish mutants recapitulates, but in a rapid manner, a human disease called Dyskeratosis congenita, which is due to deficits in a complex involved in maintaining the end of chromosomes, or telomeres,» says lead author Dr. Itamar Harel, a postdoctoral research fellow in genetics.
Dysfunction in telomere maintenance pathways plays an integral role in aging, cancer, and certain rare diseases such as dyskeratosis congenita (DC).
Dr. Agarwal is currently interested in the mechanisms and therapy of genetic blood diseases, with a focus on dyskeratosis congenita.
CAST / EiJ mTR — / — mice exhibit significant deficits in tissue renewal during adulthood, even in the first generation, and progressive worsening of the phenotype with successive generations, similar to what is seen in other background strains with these mutations and in the genetic anticipation observed in successive generations of families with autosomal dominant forms of the human genetic disorder of telomerase components, dyskeratosis congenita.