Sentences with phrase «in early drug discovery»

In a paper published in Nature Biotechnology, researchers from the Broad Institute of MIT and Harvard and the Dana - Farber Cancer Institute describe a new method that dramatically simplifies an arduous experimental process in early drug discovery.

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

Willson has been a long time supporter of precompetitive chemistry in early drug discovery and was a scientific founder of the SGC Epigenetic Chemical Probes project.

Not exact matches

These companies were early developers of drug discovery tools, and were part of an industry wide acquisition roll - up that resulted in Accelrys.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

«There are significant opportunities in outsourcing to China and India, particularly in respect to drug discovery, early development, and the preclinical and clinical sectors,» Burrill says.

Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a drug discovery and development program by focusing the selection of doses to study on those proven to deliver enough drug to the target therapeutic sites.»

«In any CNS drug discovery program,» Hargreaves says, «occupancy studies form a very early part of research.

This lecture illustrates the early stages in the planning and discovery of propranolol, an adrenaline beta - adrenergic receptor antagonist, and cimetidine, a histamine H2 - receptor antagonist — the first examples of clinically useful drugs from each of these classes.

And without knowing tankyrase's exact function, it's «too early to tell whether [the enzyme] is a good target for drug discovery,» cautions telomere expert Calvin Harley of Geron Corp. in Menlo Park, California.

Nevertheless, Canadian job opportunities in drug discovery are on the rise, Harack declares, as the local biotechnology industry enters its «early teen» phase, growing from early stage R&D to development and commercialization.

More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process.

«Alzheimer's in a dish: Stem cells from patients offer model and drug - discovery platform for early onset form of disease.»

Perera et al. now show that a flow apparatus can also accelerate reaction optimization earlier in the drug discovery process.

Draper's human organ system should be able to identify effective drugs and ineffective ones early in the drug discovery process, allowing developers to refocus resources on the strong candidates earlier and end unproductive research earlier, minimizing costs, Borenstein said.

«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.

And, to some extent, pharmaceutical companies are already moving in the direction proposed by Bountra, explicitly outsourcing more and more of the early stages of drug discovery.

«This is the first instance I am aware of where an academic drug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor of Pharmacology in the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNdrug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,» said P. Jeffrey Conn, Ph.D., Lee E. Limbird Professor of Pharmacology in the Vanderbilt University School of Medicine and director of the Vanderbilt Center for Neuroscience Drug Discovery (VCNDrug Discovery (VCNDD).

Before becoming a full - time science writer, Andy Extance worked for six and a half years in early - stage drug discovery research, followed by brief stint in silicone adhesive and rubber manufacturing.

Learn more about how we are delivering on our commitment to leading medicine from the earliest phase of discovery in a lab to the testing new drugs or therapies in clinical trials.

Enhancing the early detection of new therapies that are likely to carry a safety liability in the context of the intended patient population would provide a major advance in drug discovery.

This will provide a rich source of chemical starting points for CBCS scientists to translate novel biology into innovative drug discovery project, which may one day result in new medicines for patients in need,» said Garry Pairaudeau, Head of External Sciences, Innovative Medicines and Early Development Biotech Unit at AstraZeneca.

Using CETSA data and applications, drug discovery R&D companies are able to make better and more informed decisions at earlier stages in their projects.

The Drug Discovery & Development platform (DDD platform) will focus on early drug discovery and take promising candidates as far as demonstrating in vivo efficacy in relevant modDrug Discovery & Development platform (DDD platform) will focus on early drug discovery and take promising candidates as far as demonstrating in vivo efficacy in relevant moddrug discovery and take promising candidates as far as demonstrating in vivo efficacy in relevant models.

Building on strong drug discovery and early clinical development expertise, iTeos intends to demonstrate the clinical efficacy of its approach in proof of concept trials, on its own or in co-development with a partner.

From early attempts, a large collaborative team was eventually founded for drug discovery from «bench to bedside», directed by Dr Matthew Fuchter in the Department of Chemistry.

He became Chief Scientific Officer in 2008, responsible for developing the company's research and drug discovery strategy, and then became Executive Vice President for Genentech Research and Early Development when Genentech merged with Roche in 2009.

Being able to isolate, manipulate and image single & multiple cells in their natural environments is vital to researchers in many fields, notably those involved in drug discovery, early stage diagnosis and cellular force interactions making the addition of FluidFM ® to the world of AFM imaging and force spectroscopy an ideal pairing.

Our goal is to kick - start the drug discovery process as early as possible by removing translational delays in the transition of drug development from bench to bedside.

Debora Konz Makino, Lab Head at CRELUX / WuXi AppTec, explains:» Our long - standing collaboration with ESRF has greatly contributed to the success of most of our client's projects in the early stages of drug discovery.

Despite ongoing efforts toward finding novel entities for the treatment of the most challenging cancers, translation into patient benefit has been slow due to the fact that translational cancer research from early drug discovery to late stage drug development and assessment in clinical trials is a long process.

Oppenheim speaks of growing up in Washington and California, his father's Russian ancestry and education in China, his father's career in engineering, his mother's background and education in English, living in Richmond El Cerrito, his mother's love of the arts, his father's feelings toward Russia, standing out in the community, his relationship with his older sister, attending Richmond High School, demographics of El Cerrito, his interest in athletics during high school, fitting in with the minority class in Richmond, prejudice and cultural dynamics of the 1950s, a lack of art education and philosophy classes during high school, Rebel Without a Cause, Richmond Trojans, hotrod clubs, the persona of a good student, playing by the rules of the art world, friendship with Jimmy De Maria and his relationship to Walter DeMaria, early skills as an artist, art and teachers in high school, attending California College of Arts and Crafts, homosexuality in the 1950s and 1960s, working and attending art school, professors at art school, attending Stanford, early sculptural work, depression, quitting school, getting married, and moving to Hawaii, becoming an entrepreneur, attending the University of Hawaii, going back to art school, radical art, painting, drawing, sculpture, the beats and the 1960s, motivations, studio work, theory and exposure to art, self - doubts, education in art history, Oakland Wedge, earth works, context and possession, Ground Systems, Directed Seeding, Cancelled Crop, studio art, documentation, use of science and disciplines in art, conceptual art, theoretical positions, sentiments and useful rage, Robert Smithson and earth works, Gerry Shum, Peter Hutchinson, ocean work and red dye, breaking patterns and attempting growth, body works, drug use and hippies, focusing on theory, turmoil, Max Kozloff's «Pygmalion Reversed,» artist as shaman and Jack Burnham, sync and acceptance of the art world, machine works, interrogating art and one's self, Vito Acconci, public art, artisans and architects, Fireworks, dysfunction in art, periods of fragmentation, bad art and autobiographical self - exposure, discovery, being judgmental of one's own work, critical dissent, impact of the 1950s and modernism, concern about placement in the art world, Gypsum Gypsies, mutations of objects, reading and writing, form and content, and phases of development.

Summary: Experienced cell / molecular biologist with background in bioanalytics, cell - based & ligand bind - ing assay development / validation, early discovery of therapeutic biologics and anticancer drugs.

Background in R&D environment ranging from early work as research scientist to managing global drug discovery budget, covering biology, chemistry, toxicology, drug disposition, and translational medicine.