Sentences with phrase «in embryonic brain»

Pasco Rakic has deciphered how neurons in the embryonic brain arrange themselves during development into the highly ordered, densely interconnected, and immensely complex circuitry of the adult cerebral cortex.

Our analysis also revealed that a surprising proportion of rare devastating mutations transmitted by parents occurs in genes expressed in the embryonic brain.»

The research produced another important finding: «We were able to explain the role of iodine in embryonic brain development at the cellular level,» says Denise Stenzel.

Last year, the same researchers showed that the trigger came from cells in a structure in the embryonic brain called the floor plate, which dopamine cells brush past while migrating to their eventual home in a part of the brain called the substantia nigra.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

Not exact matches

«BPA and BPS (substitute for BPA) affect embryonic brain development in zebrafish: Low levels of chemicals linked to hyperactivity.»

The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.

The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Brain and ganglia of embryonic Periplaneta americana were grown for 2 to 3 weeks in a chemically defined medium.

Without melanin during the embryonic stage, the neuronal tracts leading from the eye to the visual cortex of the brain develop aberrantly, resulting in diminished depth perception.

For years, Scripps neuroscientist Jerold Chun had been studying the embryonic brain and how certain lipids in the blood of both the mother and the embryo affect its development.

The team used human embryonic stem cells — which can transform into any cell of the body — and cultured them in a mixture of chemicals to grow human brain cells.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

On the other hand, the problem is, you know, with embryonic stem cells, they haven't been able to get stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.

These include a family of signaling molecules called protocaderins, which regulate neuronal development and short - range interactions between neurons, and a family of transcription factors called zinc fingers, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in brain development.

Partially paralyzed rodents walk almost normally after human embryonic or fetal brain stem cells repaired their spinal cord injuries in recent studies.

Just a day after fertilization, embryonic brains begin sending signals to far - off places in the body, helping oversee the layout of complex patterns of muscles and nerve fibers.

The researchers placed an embryonic rat brain cell in each well; as the cells grew, they sent out long dendrite arms through the tunnels toward neighboring wells.

Last May in Nature Neuroscience, his lab and a team at Columbia University reported that embryonic stem cells could be used to shed light on the origins of amyotrophic lateral sclerosis (ALS), the progressive neurodegenerative disease in which motor neurons in the brain die.

Around the same time, Yoshiki Sasai of the RIKEN Center for Developmental Biology in Kobe, Japan, cultured the first brain organoids, starting not with adult stem cells but with embryonic stem cells.

If these mutations happen during embryonic development, there could be several neurological problems: the child could become autistic, kids could be born with seizure disorder, or the developing neurons might not migrate to their proper site in the brain.

Neurocutaneous disorders are caused by abnormal development of cells in the embryonic stage, leading to tumors in various parts of the body, including the skin, organs, bones, brain and spinal cord.

Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult mice could be helped by a transplant of embryonic brain cells.

McKay announced that he had mitigated the symptoms of Parkinson's in rats by using mouse embryonic stem cells that he had turned into dopamine - producing brain cells.

Are there other, intermediate embryonic cells that might, in similar fashion, give rise to the nervous system or brain?

Several years ago, one of the students in Verma's lab noticed that BRCA1 is very active in the neuroectoderm, a sliver of embryonic tissue containing neural stem cells that divide and differentiate into the brain's vast assortment of cell types and structures.

«What this work shows is that you can easily get dopamine - producing neurons in the brain,» even from undifferentiated embryonic stem cells, says developmental neurobiologist Ron McKay of the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland.

Two teams turned embryonic stem cells into brain cells, stained differently in these pictures.

What we do know is that in mice (and so, presumably, in humans) FOXP2 is active in the brain during embryonic development.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

The team injected about 2000 mouse embryonic stem cells each into the brains of 25 rats who had previously had their dopamine - producing neurons damaged, which causes a characteristic tendency to move in circles.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

The next step, he says, is to investigate how embryonic mouse brains with induced folds develop as they mature past the fetal stages of development and to look across species to see if the gene has similar effects in other mammals.

Researchers have found that a protein critical to the embryonic development of limbs also plays a role in determining how the mammalian neocortex, the outer layer of the brain, is formed.

You're going to replace every cell in the brain with embryonic stem cells?»

The dynamin - related GTPase Drp1 is required for embryonic and brain development in mice.

NeuroStemcell is focused on the identification and systematic comparison of progenitor cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals models.

Jason Lee / Reuters In the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million immature neurons derived from human embryonic stem cells into their brainIn the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million immature neurons derived from human embryonic stem cells into their brainin the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson's disease and inject 4 million immature neurons derived from human embryonic stem cells into their brains.

One way is to identify transcription factors, and one way to identify transcription factors in microRNAs that can be used for reprogramming, is to screen for them through microarrays or RNA sequencing within the embryonic brain tissue.

But things can go wrong when the embryonic brain is being built, resulting in a much smaller cortex.

Interneuron cell - based therapy in AD and related models: During brain development, embryonic interneuron precursors are generated in the medial ganglionic eminence (MGE) and retain a remarkable capacity for migration and integration in adult host brains, where they fully mature into functional inhibitory interneurons.

Human embryonic stem cell - derived neurons establish region - specific, long - range projections in theadult brain

Doctors in Moscow injected neural embryonic stem cells into the brain and spinal fluid of a boy suffering from a rare, disabling, inherited disease, ataxia telangiectasia.

We have shown that the presence of extra centrosomes in proliferating embryonic neural stem cells is sufficient to impair brain development and culminates in microcephaly (small brains) at birth.

Following this, they demonstrated that neural progenitors from embryonic stem cells could differentiate themselves into neurons in rat brains presenting lesions similar to those observed in humans.

Human embryonic stem cells grown at the University of Wisconsin - Madison randomly changed into cell types found in the A) gut B) brain C) bone marrow D) cartilage E) muscle F) kidney Scientists haven't learned to control the development.

Thomson still supports lifting Bush's restrictions, he said, because no one knows whether the new iPS cells can match embryonic cells» knack for growing into any kind of tissue — brain cells, heart muscle, insulin - producing cells and dozens of others — in mass quantities.

1 - 4 days following DNA injection and electroporation, embryonic brains are dissected, sliced, placed on a filter in culture medium and live imaged over night (Baffet et al., Methods Cell Biol., 2015).

CAMBRIDGE, Mass. — Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during embryonic brain development in zebrafish.