Fishman, in particular, wanted to advance his studies in oncodevelopmental biology, exploiting proteins involved
in embryonic development as tumor markers.
Not exact matches
As specialized cells are generated during
embryonic development, they are programmed to use only a limited amount of the total genetic information present
in the nucleus to produce the proteins required for their particular function.
«Thus, we hypothesize that Gdf3 combines with Ndr1 and Ndr2 to facilitate Nodal signaling during zebrafish
development, acting
as an essential factor
in embryonic patterning,» said Pelliccia, a graduate student
in molecular biology.
How do you visualise the extremely small forces connected to processes
in our body, such
as embryonic growth and
development?
When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish
embryonic development — specifically,
in the stem cells that give rise to the pigment cells known
as melanocytes, within a structure called the neural crest.
Manuel Eguren has analysed the biological consequences of Cdh1 elimination
in rapidly dividing cells,
as part of his doctoral research project
in Malumbres's group; he focused on progenitors from the nervous system during
embryonic development in mice.
Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking
embryonic cells seen
in the very earliest stages of human
development, known
as naïve stem cells.
Cell migration is highly coordinated and occurs
in processes such
as embryonic development, wound healing, the formation of new blood vessels, and tumour cell invasion.
In addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such as Keratin - related gene families associated with hair formation, several Hox genes that play an important role in the body plan and embryonic developmen
In addition, researchers found that the gene families related to whale's body hair and sensory receptors were contracted, such
as Keratin - related gene families associated with hair formation, several Hox genes that play an important role
in the body plan and embryonic developmen
in the body plan and
embryonic development.
The next step, he says, is to investigate how
embryonic mouse brains with induced folds develop
as they mature past the fetal stages of
development and to look across species to see if the gene has similar effects
in other mammals.
As described
in the journal Genes &
Development, the researchers identified a new pathway controlling heterochromatin organisation
in mouse
embryonic stem cells.
Other potential uses of
embryonic stem cells include investigation of early human
development, study of genetic disease and
as in vitro systems for toxicology testing.
However, malformation of skeletal bones during embryogenesis also occurs
in FOP patients and illustrates that the underlying genetic mutation occurs
in a gene with functional importance
in regulating chondro - osseous differentiation during
embryonic skeletal
development as well
as in adult musculoskeletal tissues.
In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adul
In parallel, the roles of symmetric and asymmetric cell divisions are investigated
as a mechanism for governing stem cell self - renewal and differentiation during
embryonic development and
in the adul
in the adult.
The gene, known
as gata5, acts
in embryonic cells, which are primordial, unspecialized cells that form
in the earliest stage of
embryonic development and are genetically programmed to evolve into one of many specialized cell types, such
as skeletal muscle cells, nerve cells, blood cells, skin cells, and liver cells.
They discovered that extra chromosome 21 - a genetic state known
as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which
in turn disturbs the cascade of other genes that control normal
development at the
embryonic stem cell stage.
Since the
in vitro reprogramming systems are characterised by very low efficiency Petra's lab focuses on the systems where epigenetic reprogramming occurs naturally
as a part of normal
embryonic development.
They found that groups of genes appear to work together
in heart cells
in a coordinated fashion — switching on and off
as a group at designated times during
embryonic development.
These images show human
embryonic stem cell colonies,
as grown
in 1998 by researchers at the University of Wisconsin — Madison,
in different stages of
development.
We show that DONSON is expressed
in progenitor cells of
embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early
embryonic development in mice
as well, suggesting an essential conserved role for DONSON
in the cell cycle.
For example, clusters containing genes that are upregulated during the course of ES cell differentiation (Table 3) include
in order of time of expression: cluster 30 that represents genes which take part
in the formation of the three
embryonic germ layers during gastrulation, i.e., Goosecoid, Cerberus like 1 homolog, Wnt3, Mesp1, Mixl1, mEomes and Even - skipped 1; cluster 15 containing molecular regulators of early mesoderm
development including Bmp2, Bmp5, Msx1, Msx2, Cripto, Tbx20, Hey2, Smad6, Vegfr2 (Kdr), Foxf1 and Hand1; cluster 20, which comprises regulatory and structural genes linked to hemopoiesis such
as Gata1, Nfe2, Klf1, Tie1, hemoglobins (Hba - x, Hbb - b1) and Glycophorin A; cluster 12, which is rich
in genes involved
in cardiac
development, e.g., Mef2c, Myl4, cardiac Troponin T2, Tropomodulin 1, myosin binding protein C, Bves, Angiopoietin 1 and Angiopoietin 2; and, cluster 4, which consists mostly of genes associated with neuronal
development and differentiation, for example, Neurog1, Neurog2, Olig2, Nkx6.1, Neurod4, Pou3f2, Pou3f4, Cacna2d3, Cacng4, Kcnq2 and EphA5.
Thus, the ability to measure DNAme
in single cells has the potential to make important contributions to the understanding of several key biological processes, such
as embryonic development, disease progression and aging.