Sentences with phrase «in embryonic mice»

They confirmed these same opposite patterns of SMA protein and SMN lnc - RNA in embryonic mice too.

Fong Kuan Wong (Huttner, MPG)-- «Generation of basal radial glia in the embryonic mouse dorsal telencephalon» (2014)

Not exact matches

He wrote papers like «Cloning and characterization of mouse brush border myosin - I in adult and embryonic intestine.»

Cyclooxygenase - 2 (COX - 2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1 / KO mice.

In a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beatIn a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beatin the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beats.

Menke and postdoctoral researcher Carlos Infante examined patterns of enhancer activity in embryonic limbs and genitalia of mice and limbed reptiles (anole lizards).

The ability of SIF - seq to use reporter assays in mouse embryonic stem cells to identify human embryonic stem cell enhancers that are not present in the mouse genome opens the door to intriguing research possibilities as Dickel explains.

The huntingtin gene is essential for embryonic development, and scientists have already shown that if mouse embryos don't have it at conception, they die in utero.

Repeated transfection of two expression plasmids, one containing the complementary DNAs (cDNAs) of Oct3 / 4, Sox2, and Klf4 and the other containing the c - Myc cDNA, into mouse embryonic fibroblasts resulted in iPS cells without evidence of plasmid integration, which produced teratomas when transplanted into mice and contributed to adult chimeras.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

In laboratory tests on embryonic mice engineered to not express myomerger in skeletal muscle, the animals did not develop enough muscle fiber to livIn laboratory tests on embryonic mice engineered to not express myomerger in skeletal muscle, the animals did not develop enough muscle fiber to livin skeletal muscle, the animals did not develop enough muscle fiber to live.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micIn cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micin Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of micin embryonic stem cells of mice.

Scientists have known for 20 years that SMN is necessary in every cell of the body, since disrupting the gene in a mouse causes early embryonic death, before muscle or nerve cells form.

The team also found that ERAS, a tumorigenic gene expressed in mouse embryonic stem cells and iPSCs, was mutated and dysfunctional in the mole - rat iPSCs.

Scientists, with practice, have now been able to make nuclear transfer nearly routine to produce cattle, cats, mice, sheep, goats, pigs, and — as a Korean team announced in May — even human embryonic stem (ES) cells.

The only previous demonstration — by researchers led by Shou - Wei Ding, PhD, a professor of Plant Pathology and Microbiology at UC Riverside and co-corresponding author of the current study — was done in embryonic stem cells and in newborn mice.

In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis viruIn collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis viruin Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis viruin an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis viruin cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.

The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK - 3 to cells in which the gene encoding GSK - 3 had been deleted.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

Mouse embryos: Scientists first found embryonic stem cells in mice in the 1970s, but an understanding of the critical role they play in cell differentiation only emerged years later.

The paper doesn't include any genetic analysis of the final eggs that confirms they are healthy, notes Mitinori Saitou, a stem cell biologist at Kyoto University in Japan whose team developed methods to create mouse egg cells from embryonic or reprogrammed stem cells.

Starting in the mid-2000s, Yoshiki Sasai's team at the RIKEN Center for Developmental Biology in Kobe, Japan, demonstrated how to grow brainlike structures using embryonic stem cells, first from mice and then humans.

Early in embryonic development, both mouse and human placentas rely on the same set of ancient cell - growth genes.

Upon further investigation, the team found that Noxo1 is highly expressed in the embryonic inner ear of normal mice, though its expression drops sharply after birth.

EYE CANDY Researchers grew primitive retinas (one shown, with proteins that collect and transmit light signals in green and red) by embedding mouse embryonic stem cells in a gel.

In the past few months, researchers in the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put iIn the past few months, researchers in the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put iin the United States and Japan have described a promising way of deriving embryonic stem cells from skin cells (of mice) without destroying embryos — the «Holy Grail of biotechnology,» as The Times of London put it.

• A team led by Ron McKay at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, turned mouse embryonic stem cells into isletlike cells, another step down the long road to a cure for diabetes.

One of the greatest came in November 2007, when scientists in Japan and the United States reported that they could make adult skin cells from mice revert to the embryonic state.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

Mice generated from embryonic stem cells in which ion channel genes have been mutated by homologous recombination often have a perfectly normal heart.

Wondering why the third protein, an enzyme called p66, was not, despite being very similar to the other two, Pelicci's team knocked out the piece of the gene that enabled it to code for p66, in order to make mice and mouse embryonic cells that lacked p66.

«Observing the changes in the architecture of islets during embryonic development in mice and in pseudoislets — a model we generated in our lab — was also very interesting.

The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos, as well as during motor neuron formation in mouse embryonic stem cells.

Renee Reijo Pera, a biologist at Stanford's Institute for Stem Cell Biology and Regenerative Medicine, points out that earlier attempts to create offspring with sperm from embryonic stem cells resulted in short - lived mouse pups that were either giants or midgets.

Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.

Imagine researchers» excitement, then, when Kyoto University's Shinya Yamanaka reported last year that his group had created embryolike cells directly, without transferring chromosomes, simply by injecting mouse fibroblast cells with four genes that are active in embryonic cells but not in adult ones.

In vitro experiments used human colon carcinoma cells with and without MMP9 and mouse embryonic fibroblasts, which are connective tissue cells that make the extracellular matrix and collagen and play an important role in tissue repaiIn vitro experiments used human colon carcinoma cells with and without MMP9 and mouse embryonic fibroblasts, which are connective tissue cells that make the extracellular matrix and collagen and play an important role in tissue repaiin tissue repair.

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

«Fear was three times less likely to return in mice that had received a transplant of embryonic neurons»

All of the mice produced normal amounts of SOX2 during development, when the transcription factor plays a critical role in the genesis of embryonic and neural stem cells.

Mitchell and her colleagues eliminated this possibility when they deleted these nearby regions in the genome of mice and found there was no impact on the gene's ability to be turned on in embryonic stem cells.

After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in stratified epithelia such as the esophagus, skin or vagina.

These are images of mouse embryonic stem cells which grow in a round colony of cells (A) and express Sox2 (B), shown in red.

«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.

Yong - Chun Yu at Fudan University in Shanghai, China, and his team wondered if fearful adult mice could be helped by a transplant of embryonic brain cells.

Similar SH3 binding motifs exist in the formins, proteins that function in pattern formation in embryonic limbs of the mouse, and one subtype of the muscarinic acetylcholine receptor.

McKay announced that he had mitigated the symptoms of Parkinson's in rats by using mouse embryonic stem cells that he had turned into dopamine - producing brain cells.

Embryonic stem (ES) cells, harvested from three - and - a-half-day-old mouse embryos or five - and - a-half-day-old human embryos, are referred to as pluripotent because they can become any of the thousands of cell types in the body.

The human - specific gene ARHGAP11B is expressed only in the right half of this embryonic mouse cerebral cortex.

Still, the genetic homogeneity of largely inbred mouse strains may be misleading when it comes to understanding human stem cells, cautions Peter Andrews, professor of biomedical science and co-director of the Centre for Stem Cell Biology at the University of Sheffield, U.K. «In the human, every embryonic stem cell that we're working with that comes from a different person is genetically different,» says Andrews.