The investigators identified evidence of HRD - related mutations in 11.61 percent of them, with the highest concentration of
mutations in endometrial cancer, gliomas, and ovarian cancers (38, 15 and 12 percent respectively).
Although estrogen doses in oral contraceptives have decreased appreciably over the years, with pills in the 1960s typically containing more than double the estrogen dose of pills in the 1980s, the
reduction in endometrial cancer risk was at least as great for women who used the pill during the 1980s as for those who used it in earlier decades.
Martin Widschwendter from the University College London Women's Cancer Department and colleagues, the authors of the work, systematically compared methylation
patterns in endometrial cancers and normal endometrium.
Integrate the CEP investigators into existing Endometrial Cancer SPORE projects, with the aim of ultimately developing an independent research
program in endometrial cancer.
Enhancing the development of innovative translational
researchers in endometrial cancer is critically dependent on the availability of flexible funding for career enhancement projects.
Her professional interests include universal tumor screening for Lynch
syndrome in endometrial cancer; cancer susceptibility in rare genetic syndromes; educational outreach; and psychosocial counseling in cancer - prone families.
The Career Enhancement Program (CEP) is designed to identify, recruit and mentor both junior and established scientists, including underrepresented investigators (minorities and women), for performing translational research
in endometrial cancer.