Sentences with phrase «in endoplasmic reticulum»

Proteins necessary for ciliogenesis are manufactured in the endoplasmic reticulum before traveling to the trans - Golgi network to be sorted into «zip - coded packages» or vesicles for transport to the cilia.

We further found that in SH - SY5Y cells CU6 inhibited neither β - nor γ - secretase activity, and that increased amounts of immature forms of AβPP accumulated in the endoplasmic reticulum (ER).

Notably, we found «Protein processing in endoplasmic reticulum» and «PI3K - Akt signaling pathway» might be impaired in DACD pathogenesis, while Growth factor receptor - bound protein 2 might be a crucial protein as a molecular target of the neuroprotective effects of ZBPYR.

Observations suggest that nicotine exposure affects the ratio of these receptors on the surface versus those in the endoplasmic reticulum of the cell and thus the cells» sensitivity to these receptors» natural ligands.

The evolving role of ubiquitin modification in endoplasmic reticulum - associated degradation

A new study conducted by researchers at The Wistar Institute revealed how a key protein residing in the endoplasmic reticulum (ER) helps cells respond to stress.

Targeting of the c - Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress - induced apoptosis.

Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium.

In both yeast and humans, proteins are produced in the endoplasmic reticulum, decorated with a complex of mannose and other sugars, and eventually shipped to the Golgi apparatus for further processing.

First, mild endoplasmic reticulum stress and impaired calcium release seriously disturbed mitochondrial dynamics, thus providing an explanation as to why alterations in the endoplasmic reticulum could lead to impaired mitochondrial dynamics.

Responsible for this is a diffusion barrier in the endoplasmic reticulum (a channel system within the cell that is for example important for protein synthesis and transport).

In the case of cells, one such bad consequence is the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER), the cell's protein - making factory.

In separate experiments, when Rab32 rises in response to stress in the endoplasmic reticulum, or ER, several things happen: The nerve cell fibers (both axons and the message - receiving dendrites) are shorter, mitochondria are bulkier than normal and their numbers spike.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

A protein was engineered so that it accumulated as aggregates in the endoplasmic reticulum.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

Regulation of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum

Not exact matches

In the online issue of the journal Nature, the researchers report a new function of FAM134B in the constant renewal of the endoplasmic reticulum (ER), an important cell organellIn the online issue of the journal Nature, the researchers report a new function of FAM134B in the constant renewal of the endoplasmic reticulum (ER), an important cell organellin the constant renewal of the endoplasmic reticulum (ER), an important cell organelle.

When improvising in the lab, she investigates vesicle formation at the endoplasmic reticulum.

Fat - induced stress and metabolic overload of the endoplasmic reticulum can alter its function, triggering chronic inflammation, which plays an important role in the development of atherosclerosis.

In this research, the scientists disturbed endoplasmic reticulum function by introducing saturated fatty acids into cells to induce lipotoxic stress.

Though the UPR usually promotes healthy endoplasmic reticulum function, sustained UPR activation sometimes results in diseases such as atherosclerosis, the deposition of fatty plaques on artery walls, among other conditions.

The UPR is triggered when the normal functions of the endoplasmic reticulum — the cell's largest organelle in charge of making and folding proteins — are compromised.

«If we can find molecules that modulate membralin, or identify its role in the cellular protein disposal machinery known as the endoplasmic reticulum - associated degradation (ERAD) system, this may put the brakes on neurodegeneration.»

They then separated the cells into two groups — those containing mRNAs associated with ribosomes on the endoplasmic reticulum, and those containing mRNAs associated with free - floating ribosomes in the neighboring fluid - filled space known as the cytosol.

By examining cell processes both in mice and in human cells, the researchers found out why: Re-esterification helps protect a key cell organelle called the endoplasmic reticulum (ER).

Autophagosomes arise from the endoplasmic reticulum (ER)-- a network of tubular membranes — and actin dynamics is key in their formation and movement.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

Part of the answer lies in quality control for newly - minted proteins, which takes place in the sub-cellular compartments of the «endoplasmic reticulum», or ER.

The problem with making blood stem cells proliferate outside the body is that the artificial growth gives rise to an accumulation of abnormal proteins in a part of the cell called the endoplasmic reticulum, ER.

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

This information flow may also be followed through the cell as it travels from the DNA in the nucleus, to the Cytoplasm, to the Ribosomes and the Endoplasmic Reticulum, and finally to the Golgi Apparatus, which may package the final products for export outside the cell.

Their findings suggest that the protein plays a role in increasing stress on the endoplasmic reticulum, an organelle involved in transporting and processing materials within cells.

At the endoplasmic reticulum membrane, the prion protein (PrP) can be synthesized in several topological forms.

It turns out that neuropathic pain is triggered when the body experiences endoplasmic reticulum (ER) stress, a condition in which the production and transport of protein exceeds the cells» capacities, say researchers from the University of California, Davis.

Starting in the late 1980s, their labs revealed steps in how the endoplasmic reticulum, the cell's factory for processing secreted and membrane proteins, deals with proteins whose linear sequence of amino acids hasn't folded into a proper 3D shape.

Specifically, under stress, caused by uncontrolled ingestion of fats for example, the endoplasmic reticulum — a cell organelle associated with protein synthesis and folding and lipid metabolism — stops its activity in order to re-establish cell equilibrium.

Wolfram syndrome is caused by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.

They homed in on the function of the endoplasmic reticulum (ER)-- a «mini-organ» inside cells where proteins and lipids are processed and packaged and undergo quality control before they reach their destinations in the body.

Lung fibrosis is thought to also come about when the endoplasmic reticulum (ER) in the cells of the lung becomes stressed and can no longer properly fold and unfold proteins.

In addition, gastrocnemius muscles from IL - 15Rα — KO mice expressed higher levels of mRNA for the sarcoplasmic endoplasmic reticulum calcium ATPase - II (SERCA2) and lower mRNA expression and protein content of the calcium - binding protein calsequestrin (Figure 5, F and G).

Di - acidic Motifs in the Membrane - distal C Termini Modulate the Transport of Angiotensin II Receptors from the Endoplasmic Reticulum to the Cell Surface.

In fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCIn fact, genetic and pharmacological targeting of the IRE - 1 / XBP - 1 pathway of the endoplasmic reticulum stress response, which is critical for antibody production, results in decreased numbers and reduced functions of MDSCin decreased numbers and reduced functions of MDSCs.

Role of endoplasmic reticulum calcium stores in beta - cell ER stress and lipotoxicity.

Glucose and endoplasmic reticulum calcium channels regulate HIF - 1β via presenilin in pancreatic β - cells.

Junctophilin - 4, a component of the endoplasmic reticulum — plasma membrane junctions, regulates Ca2 + dynamics in T cells.

Anterograde trafficking of G protein - coupled receptors: function of the C - terminal F (X) 6LL motif in export from the endoplasmic reticulum.

Spatial Reorganization of the Endoplasmic Reticulum during Mitosis Relies on Mitotic Kinase Cyclin A in the Early Drosophila Embryo.

Chronic enrichment of hepatic endoplasmic reticulum - mitochondria contact leads to mitochondrial dysfunction in obesity.