Sentences with phrase «in endosomes»

In their experiments the researchers measured acidity in the endosomes of brain cells of normal mice and in mice with mutations in the NHE6 gene.

In a paper published in November, working with MIT graduate student Jungmin Lee and chemistry professor Moungi Bawendi, the researchers showed that they could get quantum dots inside human cells grown in the lab, without the particles becoming confined in endosomes or clumping together.

MTMR4 attenuates transforming growth factor β (TGFβ) signaling by dephosphorylating R - Smads in endosomes.

Brunetti, C. R., Dingwell, K. S., Wale, C., Graham, F. L. & Johnson, D. C. Herpes simplex virus gD and virions accumulate in endosomes by mannose 6 - phosphate - dependent and - independent mechanisms.

This enzyme (P45 - IKKα) is generated in the endosomes, a cellular organelle that transports material which has just been added to the cells and which needs a specific acidic environment for optimal performance.

Sometimes acidity in the endosome can activate protein - degrading enzymes called proteases.

Not exact matches

However, FPs have usage limitations for imaging in low pH environments, such as in acidic organelles, including endosomes, lysosomes, and plant vacuoles.

The size of these molecules requires cells to form endosomes in order to be able to trap the compound.

In fact, we found the inhibition of acidification of endosomes enhances the effect of conventional chemotherapy in mice, «says Dr. Lluís EspinosIn fact, we found the inhibition of acidification of endosomes enhances the effect of conventional chemotherapy in mice, «says Dr. Lluís Espinosin mice, «says Dr. Lluís Espinosa.

They suggest that keeping choline levels low outside endosomes promotes the activity of an enzyme, phospholipase D, that cleaves multiple lipids and, in so doing, has a direct effect on vesicle lipid composition and thus destination.

This study demonstrates that this endosome formation (via RAB7) is very active in tumor cells but not in normal cells.

For example, antibody studies showed that it is located in the Golgi apparatus and endosomes, two structures within cells in which b - amyloid is known to be cleaved from its large precursor protein.

In their latest research, Lawrence Rajendran, of the University of Zurich in Switzerland, and his colleagues discovered that, unlike non-amyloid proteins, the Alzheimer's - associated amyloid precursor protein is cleaved by β - secretase in membrane - bound compartments inside cells, called endosomeIn their latest research, Lawrence Rajendran, of the University of Zurich in Switzerland, and his colleagues discovered that, unlike non-amyloid proteins, the Alzheimer's - associated amyloid precursor protein is cleaved by β - secretase in membrane - bound compartments inside cells, called endosomein Switzerland, and his colleagues discovered that, unlike non-amyloid proteins, the Alzheimer's - associated amyloid precursor protein is cleaved by β - secretase in membrane - bound compartments inside cells, called endosomein membrane - bound compartments inside cells, called endosomes.

Using lab - grown mouse astrocytes with variant forms of NHE9, the researchers found a change in the pH (acidity) inside cellular compartments called endosomes, which in turn altered the ability of cells to take up glutamate.

Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord.

Exosomes are small endosome derived lipid nanoparticles actively secreted by exocytosis in most living cells

Shoc2 Is Targeted to Late Endosomes and Required for Erk1 / 2 Activation in EGF - Stimulated Cells.

Platelet - activating factor - mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3 - kinase in human neutrophils.

Also, with some nanoparticles much of the material ends up trapped in protective sacs called endosomes inside the cell, and there can be potential toxic side effects.

In contrast, cholesterol was stored in special structures, called endosomes, which are distinct from lipid droplets in zebrafish intestineIn contrast, cholesterol was stored in special structures, called endosomes, which are distinct from lipid droplets in zebrafish intestinein special structures, called endosomes, which are distinct from lipid droplets in zebrafish intestinein zebrafish intestines.

We have identified and characterized its effector proteins, and reconstituted them in synthetic endosomes capable of efficient membrane fusion, comparable to the purified organelles.

Visualization of Endosome Dynamics in Living Nerve Terminals with Four - dimensional Fluorescence Imaging.

Recycling endosome - dependent and - independent mechanisms for IL - 10 secretion in LPS - activated macrophages % U http://www.jleukbio.org/content/early/2012/09/20/jlb.0412191.abstract.

«Late» macroendosomes and acidic endosomes in vertebrate motor nerve terminals % U http://onlinelibrary.wiley.com/doi/10.1002/cne.23176/abstract.

Modulation of insulin signalling and calcium homeostasis by endosomes in pancreatic beta - cells.

Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes.

To do that, he needs to make the ribonucleoprotein complex stable in the bloodstream, able to escape the cell's endosome, and even able to home in on a particular tissue type.

From there, it must sneak across cell membranes, escape the acidic environment of the cell's endosomes to find the nucleus, and then home in on the correct location on the DNA.

Therefore vesicle - like stainings are annotated as «vesicles» in the Human Protein Atlas and the terms «endosomes», «lysosomes» and «peroxisomes» are only used if colocalization experiments were carried out.

Aβ is generated from amyloid - β protein precursor (AβPP) by two sequential proteolytic cleavage steps involving β - and γ - secretases in the trans - Golgi network and endosomes.

The Johannes group has made two major contributions in this context: the discovery of a membrane trafficking interface between early endosomes and the Golgi apparatus, and the demonstration that dynamic protein - induced glycosphingolipid reorganization acts as a driving force for membrane invagination in clathrin - independent endocytosis.

In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.

If it works at ph 5 - 5.5 the reaction is likely happening inside endosomes inside of the cell where the ph is supposed to be in that range.